Abstract:
AIM:It is now necessary to investigate whether recovery in psychosis is possible without the use of antipsychotic medication. This study will determine (1) whether a first-episode psychosis (FEP) group receiving intensive psychosocial interventions alone can achieve symptomatic remission and functional recovery; (2) whether prolonging the duration of untreated psychosis (DUP) in a sub-group according to randomisation will be associated with a poorer outcome and thereby establish whether the relationship between DUP and outcome is causative; and (3) whether neurobiological changes observed in FEP are associated with the psychotic disorder or antipsychotic medication. Baseline characteristics of participants will be presented. METHODS:This study is a triple-blind randomized placebo-controlled non-inferiority trial. The primary outcome is the level of functioning measured by the Social and Occupational Functioning Assessment Scale at 6 months. This study is being conducted at the Early Psychosis Prevention and Intervention Centre, Melbourne and includes young people aged 15 to 24 years with a DSM-IV psychotic disorder, a DUP less than 6 months and not high risk for suicide or harm to others. Strict discontinuation criteria are being applied. Participants are also undergoing three 3-Tesla-MRI scans. RESULTS:Ninety participants have been recruited and baseline characteristics are presented. CONCLUSIONS:Staged treatment and acceptability guidelines in early psychosis will determine whether antipsychotic medications are indicated in all young people with a FEP and whether antipsychotic medication can be safely delayed. Furthermore, the relative contribution of psychotic illness and antipsychotic medication in terms of structural brain changes will also be elucidated. The findings will inform clinical practice guidelines.
journal_name
Early Interv Psychiatryjournal_title
Early intervention in psychiatryauthors
O'Donoghue B,Francey SM,Nelson B,Ratheesh A,Allott K,Graham J,Baldwin L,Alvarez-Jimenez M,Thompson A,Fornito A,Polari A,Berk M,Macneil C,Crisp K,Pantelis C,Yuen HP,Harrigan S,McGorry Pdoi
10.1111/eip.12716subject
Has Abstractpub_date
2019-08-01 00:00:00pages
953-960issue
4eissn
1751-7885issn
1751-7893journal_volume
13pub_type
杂志文章,随机对照试验abstract:AIM:Looking after someone in the early stages of psychosis can have a negative impact on caregivers, but there is little clarity about which interventions, if any, caregivers should be offered. This study investigated sleep disturbances in early psychosis caregivers and the relationship between their sleep quality and ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12538
更新日期:2019-06-01 00:00:00
abstract:AIM:Auditory hallucinations are hypothesized to be based in distorted sensory perceptions, with increasingly distorted perceptions of reality possibly prompting the first psychotic phase of schizophrenia spectrum disorders. Our goal was to examine the association between distorted auditory perceptions and psychotic sym...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12150
更新日期:2015-06-01 00:00:00
abstract:AIM:People diagnosed with mental disorders experience higher rates of unemployment than those without. Career adaptability, defined as the ability to respond flexibly and make informed career decisions in work and throughout career transitions, is becoming increasingly important as the nature of work changes rapidly. E...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13100
更新日期:2021-01-10 00:00:00
abstract:AIM:Within schizophrenia, genetic factors contribute greatly to risk, yet genetic testing for the disorder is not available. For some individuals with specific genotypes, cannabis use may increase risk of schizophrenia. It is possible that genetic tests could be offered in the future to inform individuals of the risk o...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12164
更新日期:2016-06-01 00:00:00
abstract:AIM:There has been considerable interest in identifying and addressing the specific needs of early-episode patients diagnosed with schizophrenia in the hope that by addressing such needs early, chronic disabilities can be avoided. METHODS:One hundred twenty-eight early-episode and 571 chronic patients were compared on...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2012.00387.x
更新日期:2013-02-01 00:00:00
abstract:AIM:Prior to the release of the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders, experts in the field of psychosis research considered including a psychosis high-risk syndrome-attenuated psychosis syndrome-as a formal diagnosis. Opponents argued that such a diagnosis may increase the risk of...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12710
更新日期:2019-08-01 00:00:00
abstract:AIM:Individuals with a diagnosis of schizophrenia have a reduced life expectancy compared with the general population and cardiovascular disease is the major contributor to this early mortality. The use of second-generation antipsychotic (SGA) medications is associated with significant weight gain and metabolic side ef...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12083
更新日期:2014-08-01 00:00:00
abstract:AIM:Olfactory identification deficits (OIDs) are seen in schizophrenia patients and individuals at increased risk for psychosis but its pathophysiology remains unclear. Although dopaminergic imbalance is known to lie at the core of schizophrenia symptomatology, its role in the development of OIDs has not been elucidate...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12183
更新日期:2016-10-01 00:00:00
abstract:AIMS:Earlier detection and treatment of psychosis is associated with improved health outcomes. While the role of specialist services to facilitate early diagnosis and treatment has been extensively described internationally, little data on their impact on general practice has been reported. A new specialist service for...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2008.00065.x
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Evidence suggests that many people with obsessive-compulsive disorder (OCD) have subclinical symptoms years before the development of their disorder and that early treatment may reduce its severity. AIM:To explore prevention and early intervention strategies for OCD. METHODS:A narrative literature review w...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/eip.12535
更新日期:2018-08-01 00:00:00
abstract:AIMS:Individual Placement and Support is the most defined and evidence-based approach to supported employment for severe mental illness, including recent-onset psychosis. However, there is limited evidence or detailed guidelines informing the management of mental illness disclosure to educators or employers when delive...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12030
更新日期:2013-08-01 00:00:00
abstract:AIM:To help clinicians carry out a comprehensive, medical diagnostic assessment in first-episode patients who are suspected of developing schizophrenia. METHODS:Conceptual review of the published work with emphasis on the diagnostic goals of excluding medical causes of psychosis and establishing a medical baseline. R...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,评审
doi:10.1111/j.1751-7893.2008.00105.x
更新日期:2009-02-01 00:00:00
abstract:AIM:To determine duration of untreated psychosis (DUP) in patients with schizophrenia-spectrum disorders from Serbia and to analyse factors that potentially contribute to the treatment delay, with focus on personality traits. METHODS:Fifty seven patients (males 54.4%; age = 29.9 ± 6.0 yrs; age at the illness onset = 2...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12348
更新日期:2018-02-01 00:00:00
abstract:AIM:This paper considers the priorities for policy to promote youth mental health in Australia. The Ottawa Charter is applied as a conceptual framework to determine current strengths and future priorities across the entire spectrum of interventions for mental health promotion. METHODS:The five platforms of the Ottawa ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2010.00239.x
更新日期:2011-02-01 00:00:00
abstract:AIM:Improvement of social adjustment is a major aim of indicated prevention in young people at risk of developing psychosis. The present study explores the effect of specific cognitive behaviour therapy (CBT) as compared with supportive counselling (SC) on social adjustment in people in a potential early initial prodro...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1751-7893.2007.00013.x
更新日期:2007-02-01 00:00:00
abstract:AIM:To explore the differences in pharmacotherapy and clinical characteristics of individuals at ultra-high-risk (UHR) for psychosis according to the conversion status, we analyzed the data for UHR patients seen at the Seoul Youth Clinic. METHODS:This was a naturalistic observational study. We obtained clinical data, ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00295.x
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:Approximately 80 000 children and young people in the UK suffer from depression, but many are untreated because of poor identification of early warning signs and risk factors. AIMS:This study aimed to derive and to investigate discrimination characteristics of a prediction model for a first recorded diagnos...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12332
更新日期:2018-06-01 00:00:00
abstract:AIMS:The aims of this study were 3-fold. We wished to investigate whether at baseline entry to an ultra-high risk (UHR) clinic whether: (1) perceptual abnormalities are more prevalent in those young people with co-morbid psychiatric diagnoses, (2) perceptual abnormalities are more prevalent in those young people with h...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12469
更新日期:2019-04-01 00:00:00
abstract:AIM:Although models of family intervention are clearly articulated in the child and early adolescent literature, there is less clarity regarding family intervention approaches in later adolescence and emerging adulthood. METHODS:This study provides the rationale and intervention framework for a developmentally sensiti...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12383
更新日期:2018-04-01 00:00:00
abstract:AIMS:The current study sought to determine what factors inhibited psychologists, naturopaths and fitness instructors from detecting an eating disorder (ED), and the discipline differences across these factors. METHODS:Participants of the online study were 115 health practitioners who consisted of 35 psychologists, 50 ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12940
更新日期:2020-03-20 00:00:00
abstract:AIM:It has been found that long-chain omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of progression to first episode of psychosis (FEP) and may offer a safe and efficacious strategy for selective and indicated prevention in young people with ultra-high-risk (UHR) states. An opportunity for exploring the tr...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章,随机对照试验
doi:10.1111/eip.12197
更新日期:2016-10-01 00:00:00
abstract:AIM:To examine whether roles of peer specialists affect service use among Black, Latinx and White youth ages 16-24 with serious mental illness (SMI) in Los Angeles and San Diego Counties. METHODS:Administrative data from 2015 to 2018 was used to summarize service use among 6329 transition age youth age 16-24 with SMI ...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13036
更新日期:2020-09-04 00:00:00
abstract:AIM:Ultrahigh risk (UHR) criteria, consisting of brief limited intermittent psychotic symptoms (BLIPS), attenuated psychotic symptoms (APS) and genetic risk and deterioration (GRD) syndrome are the most widely used criteria for assessing the clinical high-risk state for psychosis (CHR-P). The Basel Screening Instrument...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12719
更新日期:2019-08-01 00:00:00
abstract:AIM:Adolescents with psychotic disorders show deficits in IQ, attention, learning and memory, executive functioning, and processing speed that are related to important clinical variables including negative symptoms, adaptive functioning and academics. Previous studies have reported relatively consistent deficits with v...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2008.00075.x
更新日期:2008-08-01 00:00:00
abstract:AIM:Neurophysiological markers of schizophrenia may help identify individuals who are at an increased risk of developing psychosis. As an operational measure of sensorimotor gating, pre-pulse inhibition (PPI) deficit has been investigated in clinical high-risk (CHR) individuals. In this study, we performed a systematic...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13015
更新日期:2020-07-24 00:00:00
abstract:AIMS:Depression in adolescents is common and debilitating. Treatment approaches vary widely across clinics and may not reflect evidence-based care. Integrated care pathways (ICPs) are implementation tools to facilitate bridging the gap between rigorous but often complex clinical practice guidelines and what is actually...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12918
更新日期:2020-08-01 00:00:00
abstract:AIMS:This report discusses the use of antinuclear antibody (ANA) detection as a screening test for neuropsychiatry systemic lupus erythematosus (NPSLE) in patients presenting a first-episode psychosis. METHODS:We reviewed the medical records of 85 patients admitted to an emergency service due to first-episode psychosi...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/j.1751-7893.2011.00339.x
更新日期:2012-08-01 00:00:00
abstract:AIM:Individual Placement and Support is an effective vocational intervention for increasing competitive employment for people with severe mental illness. Little is known, however, about its effectiveness in the context of early psychosis. This study assesses improvements in clients' employment in a phase of illness dur...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.13005
更新日期:2020-06-24 00:00:00
abstract:AIM:The duration of untreated psychosis (DUP) refers to the period of time between the emergence of psychotic symptoms and the initiation of appropriate clinical treatment. Prolonged DUP is associated with a range of adverse consequences, including more severe illness course, cognitive deficits and poor functioning. Pr...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12308
更新日期:2017-06-01 00:00:00
abstract:AIM:The Meals, Mindfulness, & Moving Forward (M3 ) programme included nutrition education, hands-on cooking classes, mindfulness meditation practice, physical activities and facilitated group sharing. M3 was designed as a supplement to standard care for youths (age 15-25 years) with first-episode psychosis (FEP) who we...
journal_title:Early intervention in psychiatry
pub_type: 杂志文章
doi:10.1111/eip.12913
更新日期:2021-02-01 00:00:00