Platelet activation markers in children with congenital heart disease associated with pulmonary arterial hypertension.

Abstract:

BACKGROUND:Mean platelet volume (MPV), platecrit, and platelet distribution width (PDW) are markers of platelet activation. Previous studies have found that platelet activation occurs in patients with pulmonary arterial hypertension. Platelet indices including MPV, PDW, and platecrit have not been studied in children with congenital heart disease associated pulmonary arterial hypertension (APAH-CHD) who survived and those who died. OBJECTIVE:The objective of this study to investigate the value of platelet indices with clinical and hemodynamic indicators predicting the disease severity and survival in children with APAH-CHD. METHODS:This was a nested case-control study. MPV, platecrit, and PDW levels measured in 37 patients with APAH-CHD and 43 healthy subjects at the beginning of the study. Right heart catheterization was performed in all 37 patients. Clinical and hemodynamic data were collected. All patients were followed from the date of laboratory testing. The study was conducted between March 2012-July 2015. The comparison of clinical, hemodynamic data and platelet indices were made between patients with APAH-CHD who died than APAH-CHD patients who survived. RESULTS:Of 37 patients, after a mean follow-up duration of 67.90 ± 47.90 months, 11 patients died. MPV (12.10 femoliter [fL; 8.20-12.50] vs 8.70 fL [6.40-9.70], P = .007), PDW (16.88 ± 1.09% vs 15.75 ± 1.58%, P = .04) and platecrit (0.28 ± 0.31 vs 0.22 ± 0.27, P = .01) were significantly higher in the patients with APAH-CHD who died than those who survived. Pearson's correlation analysis showed that MPV correlated with mean pulmonary artery pressure (r = 0.332, P = .04) and correlated negatively with six-minute walking distance (r = -0.600. P = .00). PDW and platecrit correlated positively with mean pulmonary artery pressure (r = 0.373, P = .02; r = 0.389, P = .01, respectively). CONCLUSION:Our results showed that MPV, platecrit and PDW were increased in children with APAH-CHD. They might give clue about disease severity.

journal_name

Congenit Heart Dis

journal_title

Congenital heart disease

authors

Mese T,Guven B,Yilmazer MM,Karadeniz C,Ozdemir R,Doksoz O

doi

10.1111/chd.12616

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

506-511

issue

4

eissn

1747-079X

issn

1747-0803

journal_volume

13

pub_type

杂志文章
  • A qualitative assessment of pediatric cardiology core content: Comments from Kentucky trainees, pediatricians, and pediatric cardiologists.

    abstract:OBJECTIVE:The 2016 American Board of Pediatrics (ABP) content outline is comprehensive, including more than 50 cardiology-specific objectives within eight content areas. This study complements the quantitative analysis of a Kentucky-wide survey of trainees, pediatricians, and pediatric cardiologists asking them to iden...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12626

    authors: Neal AE,Lehto E,Miller KH,Davis E,Ziegler C

    更新日期:2018-09-01 00:00:00

  • Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta.

    abstract:OBJECTIVE:Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B-natriuretic peptide are biomarkers that have been associated with pathologic LV ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12744

    authors: Frank BS,Urban TT,Lewis K,Tong S,Cassidy C,Mitchell MB,Nichols CS,Davidson JA

    更新日期:2019-05-01 00:00:00

  • Sex-related disparity in surgical mortality among pediatric patients.

    abstract:BACKGROUND:It has been reported that gender differences in cardiovascular outcomes found in adults also are present in children who undergo surgical repair for congenital heart disease. METHODS:California statewide hospital discharge data 1989-99 were used to study outcomes in children <18 years undergoing cardiac sur...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2006.00013.x

    authors: Klitzner TS,Lee M,Rodriguez S,Chang RK

    更新日期:2006-05-01 00:00:00

  • Surveillance and screening practices of New England congenital cardiologists for patients after the Fontan operation.

    abstract:INTRODUCTION:Surveillance and management guidelines for Fontan patients are lacking due to the paucity of evidence in the literature of screening efficacy on outcome measures. METHODS:The Fontan Working Group within the New England Congenital Cardiology Association designed an electronic survey to assess surveillance ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12854

    authors: Davey BT,Toro-Salazar OH,Gauthier N,Valente AM,Elder RW,Wu FM,Berman N,Pollack P,Lee JH,Rathod RH

    更新日期:2019-11-01 00:00:00

  • Chronic Arrhythmias in the Setting of Heterotaxy: Differences between Right and Left Isomerism.

    abstract::So-called heterotaxy affects lateralization of the thoracic and abdominal organs. Congenital malformations may be present in one of several organ systems. Cardiac involvement includes both structural and conduction abnormalities. Data regarding arrhythmias in heterotaxy come from case reports and small case series. We...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审

    doi:10.1111/chd.12288

    authors: Loomba RS,Willes RJ,Kovach JR,Anderson RH

    更新日期:2016-01-01 00:00:00

  • Echocardiographic evaluation of pressure gradient across the stent in patients treated for coarctation of the aorta.

    abstract:OBJECTIVE:Stent placement has become a widely used method of treatment for coarctation of the aorta (COA). Our goal was to find echocardiographic indices that would correlate best with directly measured gradients across the coarctation stent. MATERIAL AND METHODS:Pediatric patients with COA who underwent intra-aortic ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2009.00300.x

    authors: Tang L,Forbes TJ,Du W,Zilberman MV

    更新日期:2009-07-01 00:00:00

  • Comparison of the Effects of Dexmedetomidine and Propofol on Hemodynamics and Oxygen Balance in Children with Complex Congenital Heart Disease Undergoing Cardiac Surgery.

    abstract:OBJECTIVE:The aim of this study was to compare the effects of anesthesia by dexmedetomidine and propofol on the hemodynamics and oxygen balance in children with complex congenital heart disease who were undergoing cardiac surgery. METHODS:Fifty-seven children were randomized to receive either a continuous infusion of ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/chd.12228

    authors: Cheng X,Zuo Y,Zhao Q,Gu E,Huang Y

    更新日期:2015-05-01 00:00:00

  • Long QT syndrome unmasked by dexmedetomidine: a case report.

    abstract::Dexmedetomidine is a selective alpha-2 adrenergic agonist that is used frequently for short-term sedation in children. It has been noted to cause hypertension, hypotension, bradycardia, and sinus pauses; however, QTc prolongation has not been reported with dexmedetomidine administration. We describe a case of marked Q...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12055

    authors: Burns KM,Greene EA

    更新日期:2014-01-01 00:00:00

  • Exercise responses in children and adults with a Fontan circulation at simulated altitude.

    abstract:BACKGROUND:Traveling to high altitude has become more popular. High-altitude exposure causes hypobaric hypoxia. Exposure to acute high altitude, during air travel or mountain stays, seems to be safe for most patients with congenital heart disorders (CHD). Still, current guidelines for CHD patients express concerns rega...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12850

    authors: Takken T,Evertse A,de Waard F,Spoorenburg M,Kuijpers M,Schroer C,Hulzebos EH

    更新日期:2019-11-01 00:00:00

  • Complete heart block due to Lyme carditis in two pediatric patients and a review of the literature.

    abstract::Carditis is a common manifestation of adult patients with Lyme disease affecting 4-10% of Lyme patients in the United States. However, children with Lyme disease rarely present with acute carditis. The management of pediatric patients with complete heart block (CHB) secondary to Lyme carditis has not been well describ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审

    doi:10.1111/j.1747-0803.2007.00122.x

    authors: Silver E,Pass RH,Kaufman S,Hordof AJ,Liberman L

    更新日期:2007-09-01 00:00:00

  • Knowledge and attitudes of anesthesia providers about noncardiac surgery in adults with congenital heart disease.

    abstract:OBJECTIVE:To examine the knowledge and attitudes of anesthesia providers in relation to the care of adult congenital heart disease (ACHD) patients presenting for noncardiac surgery. DESIGN/SETTING:A novel survey was designed and administered to 168 anesthesiologists across a single academic department in a range of pr...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12076

    authors: Maxwell BG,Williams GD,Ramamoorthy C

    更新日期:2014-01-01 00:00:00

  • Metabolic Uncoupling Following Cardiopulmonary Bypass.

    abstract:OBJECTIVE:The objective of this study was to characterize the natural history of metabolic uncoupling (type B hyperlactemia and hyperglycemia) following cardiopulmonary bypass (CPB), and to determine the impact of insulin therapy on time to lactate normalization in patients without low cardiac output. DESIGN:The desig...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12285

    authors: Palermo RA,Palac HL,Wald EL,Wainwright MS,Costello JM,Eltayeb OM,Backer CL,Epting CL

    更新日期:2015-11-01 00:00:00

  • Atrial baffle problems following the Mustard operation in children and young adults with dextro-transposition of the great arteries: the need for improved clinical detection in the current era.

    abstract:OBJECTIVE:Intraatrial Mustard baffle repair of dextro-transposition of the great arteries (d-TGA) is vulnerable to complications, typically obstruction and leaks. Because patients often require pacemakers or intracardiac electrophysiology studies (EPS)/ablation for arrhythmias, narrowed or obstructed baffles restrict c...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2011.00532.x

    authors: Patel S,Shah D,Chintala K,Karpawich PP

    更新日期:2011-09-01 00:00:00

  • Effect of Left Cardiac Sympathetic Denervation on the Electromechanical Window in Patients with either Type 1 or Type 2 Long QT Syndrome: A Pilot Study.

    abstract:BACKGROUND:Left cardiac sympathetic denervation (LCSD) exerts significant antifibrillatory effects in patients with long QT syndrome (LQTS). Recently, electromechanical window (EMW) has emerged as a novel torsadogenic marker in LQTS, superior to QT interval (QTc) in distinguishing symptomatic from asymptomatic patients...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12332

    authors: Schneider AE,Bos JM,Ackerman MJ

    更新日期:2016-09-01 00:00:00

  • Longitudinal Strain by Speckle Tracking Echocardiography in Pediatric Heart Transplant Recipients.

    abstract:INTRODUCTION:Heart transplant recipients are at risk for developing left ventricular (LV) dysfunction. While traditional echocardiographic parameters have limitations, speckle tracking echocardiography (STE) is a novel technique shown to be more sensitive and accurate in adult studies for evaluating ventricular systoli...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12263

    authors: Buddhe S,Richmond ME,Gilbreth J,Lai WW

    更新日期:2015-07-01 00:00:00

  • Emotional functioning of adolescents and adults with congenital heart disease: a meta-analysis.

    abstract:OBJECTIVE:This study aimed to quantitatively compare findings of emotional functioning across studies of adolescents and adults with congenital heart disease (CHD) through meta-analysis. DESIGN:The current meta-analysis included 22 studies of adolescent and adult survivors of CHD who completed measures of emotional fu...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/chd.12178

    authors: Jackson JL,Misiti B,Bridge JA,Daniels CJ,Vannatta K

    更新日期:2015-01-01 00:00:00

  • Aortic perfusion score for pulmonary atresia with intact ventricular septum: An antegrade coronary perfusion scoring system that is predictive of need for transplant and mortality.

    abstract:BACKGROUND:Pulmonary atresia with intact ventricular septum is a unique congenital malformation of the heart in which patients may undergo single-, two- or 1½- ventricle repair. Size of the tricuspid valve annulus, morphology of the right ventricle and presence of ventriculocoronary connections can all impact the selec...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12510

    authors: Loomba RS,Pelech AN

    更新日期:2018-01-01 00:00:00

  • Insights from Cardiac Mechanics after Three Decades from Successfully Repaired Aortic Coarctation.

    abstract:BACKGROUND AND AIMS:Patients who underwent a successful repair of the aortic coarctation show chronic hyperdynamic state and normal left ventricular (LV) geometry; however, there are few data regarding the LV systolic function in the long term. Accordingly, we assessed LV systolic mechanics and factors associated with ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,多中心研究

    doi:10.1111/chd.12310

    authors: Faganello G,Fisicaro M,Russo G,Iorio A,Mazzone C,Grande E,Humar F,Cherubini A,Pandullo C,Barbati G,Tarantini L,Benettoni A,Pozzi M,Di Lenarda A,Cioffi G

    更新日期:2016-05-01 00:00:00

  • Hyponatremia and its association with the neurohormonal activity and adverse clinical events in children and young adult patients after the Fontan operation.

    abstract:BACKGROUND:Hyponatremia (HN) is relatively common in adults with congenital heart disease and is a powerful predictor of mortality. However, the precise relationship of HN to the Fontan pathophysiology remains unknown. PURPOSE:Our study aimed to clarify the association of HN to the Fontan pathophysiology. METHODS AND...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2011.00503.x

    authors: Ohuchi H,Negishi J,Ono S,Miyake A,Toyota N,Tamaki W,Miyazaki A,Yamada O

    更新日期:2011-07-01 00:00:00

  • Recurrent exacerbations of protein-losing enteropathy after initiation of growth hormone therapy in a Fontan patient controlled with spironolactone.

    abstract::Protein-losing enteropathy (PLE) is a rare, but serious complication in single ventricle patients after Fontan palliation, and is associated with a 5-year mortality of 46%. We describe a patient with PLE after Fontan palliation who achieved remission with high-dose spironolactone (an aldosterone antagonist), but had t...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2009.00320.x

    authors: Grattan MJ,McCrindle BW

    更新日期:2010-03-01 00:00:00

  • Hydrogel expandable coils for vascular occlusion in congenital cardiovascular disease: a single center experience.

    abstract:OBJECTIVE:  The objective of this study is to evaluate the safety and feasibility of the AZUR hydrogel-polymer coated platinum coil (hydrocoil) for vascular occlusion in patients with congenital cardiovascular disease (CCVD). DESIGN:  Retrospective case review. PATIENTS:  Eight patients with CCVD who underwent attemp...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2011.00583.x

    authors: Goldstein BH,Aiyagari R,Bocks ML,Armstrong AK

    更新日期:2012-05-01 00:00:00

  • Familial Atrial Septal Defect and Sudden Cardiac Death: Identification of a Novel NKX2-5 Mutation and a Review of the Literature.

    abstract:OBJECTIVE:Atrial septal defect (ASD) is the second most common congenital heart defect (CHD) and is observed in families as an autosomal dominant trait as well as in nonfamilial CHD. Mutations in the NKX2-5 gene, located on chromosome 5, are associated with ASD, often combined with conduction disturbances, cardiomyopat...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审

    doi:10.1111/chd.12317

    authors: Ellesøe SG,Johansen MM,Bjerre JV,Hjortdal VE,Brunak S,Larsen LA

    更新日期:2016-05-01 00:00:00

  • Endovascular stenting for native coarctation of the aorta is an effective alternative to surgical intervention in older children.

    abstract:OBJECTIVE:Assess the early and intermediate results with respect to blood pressure control in older children undergoing endovascular stenting for native coarctation of the aorta. DESIGN:Eleven hypertensive patients (10 +/- 3 years of age) underwent endovascular stenting via standard techniques for native coarctation o...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2007.00148.x

    authors: Weber HS,Cyran SE

    更新日期:2008-01-01 00:00:00

  • Diagnostic role of magnetic resonance imaging in identifying aortic arch anomalies.

    abstract:PURPOSE:The aim of this article was to assess the role of MRI in the diagnosis and management of a variety of complex aortic arch anomalies. MATERIALS AND METHODS:Imaging was performed on a 1.5T Philips Gyroscan Intera. We retrospectively reviewed all cardiac MR scans performed from November 2003 to February 2007 at o...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2008.00174.x

    authors: Cantinotti M,Hegde S,Bell A,Razavi R

    更新日期:2008-03-01 00:00:00

  • Echocardiography and management of sick neonates in the intensive care unit.

    abstract::To evaluate the influence of echocardiographic examination in the clinical management of the sick neonate, 241 patients, admitted to the neonatal intensive care unit of a tertiary referral center that had echocardiograms with data available for review, were enrolled in a retrospective study. Asymptomatic murmurs (45%)...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2008.00209.x

    authors: Kadivar M,Kiani A,Kocharian A,Shabanian R,Nasehi L,Ghajarzadeh M

    更新日期:2008-09-01 00:00:00

  • Atresia of abdominal aorta in neonate with recanalization and development of normal aortic architecture: case report and review of literature.

    abstract::This is a case report reviewing the presentation and clinical course of a patient diagnosed with abdominal aortic atresia at the level caudal to the superior mesenteric artery. Patients with abdominal aortic atresia need to be evaluated for associated underlying syndromes or diseases. Although the prognosis for this d...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审

    doi:10.1111/j.1747-0803.2010.00454.x

    authors: Brown J,Shehata BM,Campbell R

    更新日期:2011-05-01 00:00:00

  • Protein-losing enteropathy after the Fontan operation: associations and predictors of clinical outcome.

    abstract:OBJECTIVE:We sought to define what clinical parameters were related to the ultimate outcome in Fontan patients who had developed protein-losing enteropathy (PLE). BACKGROUND:PLE is a serious complication of the Fontan operation. Several preoperative and perioperative findings are associated with later PLE. However, th...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2008.00200.x

    authors: Silvilairat S,Cabalka AK,Cetta F,Grogan M,Hagler DJ,O'Leary PW

    更新日期:2008-07-01 00:00:00

  • Thrombus in right ventricular outflow tract: unique cause of refractory cyanotic spell.

    abstract::Iron deficiency state in patients with cyanotic congenital heart disease can mimic as well as aggravate hyperviscosity symptoms. Correction of iron deficiency in these cases is expected to improve symptoms. We report an unexpected occurrence of refractory cyanotic spell in a child with tetralogy of Fallot due to throm...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/j.1747-0803.2011.00608.x

    authors: Gupta SK,Saxena A,Anil OM,Bisoi AK

    更新日期:2012-07-01 00:00:00

  • Midgestation fetal pulmonary annulus size is predictive of outcome in tetralogy of fallot.

    abstract:BACKGROUND:Surgical management of tetralogy of Fallot (TOF) is increasingly moving toward valve-sparing approaches rather than transannular patch (TAP). We evaluate whether fetal pulmonary valve (PV) size is predictive of postnatal course and surgical approach in TOF. METHODS:In this retrospective study, fetal and pos...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12120

    authors: Friedman K,Balasubramanian S,Tworetzky W

    更新日期:2014-05-01 00:00:00

  • Genetic testing practices in infants with congenital heart disease.

    abstract:OBJECTIVE:Clinical genetic testing is expanding rapidly, but the application of new testing has not been reported in an unselected, comprehensive congenital heart disease (CHD) patient population. This study aims to identify cytogenetic testing practices and diagnostic yield in infants with CHD as an important first st...

    journal_title:Congenital heart disease

    pub_type: 杂志文章

    doi:10.1111/chd.12112

    authors: Connor JA,Hinton RB,Miller EM,Sund KL,Ruschman JG,Ware SM

    更新日期:2014-03-01 00:00:00