Proteomic Analysis of Charcoal-Stripped Fetal Bovine Serum Reveals Changes in the Insulin-like Growth Factor Signaling Pathway.

abstract：:Amphotericin B (AmB) is a polyene antifungal drug widely used for systemic fungal infections. In this study, a metabonomic method using gas chromatography-mass spectrometry (GC/MS) was developed to characterize the metabolic profiles of Candida albicans cells exposed to AmB. Thirty-one differentially produced metaboli...

journal_title：Journal of proteome research

authors： Cao Y,Zhu Z,Chen X,Yao X,Zhao L,Wang H,Yan L,Wu H,Chai Y,Jiang Y

更新日期：2013-06-07 00:00:00

abstract：:Peptide abundance estimation is generally the first step in protein quantification. In peptide abundance estimation, peptide overlapping and peak intensity variation are two challenges. The main objective of this paper is to estimate peptide abundance by taking advantage of peptide isotopic distribution and smoothness...

journal_title：Journal of proteome research

authors： Yang C,Yang C,Yu W

更新日期：2010-05-07 00:00:00

abstract：:Various biological activities of immunoglobulin G (IgG) including antibody-dependent cellular cytotoxicity (ADCC) are modulated by the structural features of the N-glycans in the Fc part. In this study, we describe a population of IgG1 alloantibodies which are formed during pregnancy against human platelet antigens (H...

journal_title：Journal of proteome research

authors： Wuhrer M,Porcelijn L,Kapur R,Koeleman CA,Deelder A,de Haas M,Vidarsson G

更新日期：2009-02-01 00:00:00

abstract：:Colorectal cancer (CRC) is a growing cause of mortality in developing countries, warranting investigation into its etiopathogenesis and earlier diagnosis. Here, we investigated the fecal metabolic phenotype of patients with advanced colorectal neoplasia and controls using (1)H-nuclear magnetic resonance (NMR) spectros...

journal_title：Journal of proteome research

authors： Amiot A,Dona AC,Wijeyesekera A,Tournigand C,Baumgaertner I,Lebaleur Y,Sobhani I,Holmes E

更新日期：2015-09-04 00:00:00

abstract：:Vascular leakage is a hallmark of severe dengue infection. Although extensive studies have been conducted during the past several decades, the molecular mechanisms underlying vascular leakage in dengue shock syndrome (DSS) remain unclear. We thus performed a proteomics study to characterize responses in human endothel...

journal_title：Journal of proteome research

authors： Kanlaya R,Pattanakitsakul SN,Sinchaikul S,Chen ST,Thongboonkerd V

更新日期：2009-05-01 00:00:00

abstract：:Phosphorylation enhances IGFBP-1 binding to IGF-I, thereby limiting the bioavailability of IGF-I that may be important in fetal growth. Our goal in this study was to determine whether changes in site-specific IGFBP-1 phosphorylation were unique to fetal growth restriction. To establish a link, we compared IGFBP-1 phos...

journal_title：Journal of proteome research

authors： Abu Shehab M,Khosravi J,Han VK,Shilton BH,Gupta MB

更新日期：2010-04-05 00:00:00

abstract：:Glycolysis is the core metabolic pathway supplying energy to cells. Whereas the vast majority of studies focus on specific aspects of the process, global analyses characterizing simultaneously all enzymes involved in the process are scarce. Here, we demonstrate that quantitative label- and standard-free proteomics all...

journal_title：Journal of proteome research

authors： Wiśniewski JR,Gizak A,Rakus D

更新日期：2015-08-07 00:00:00

abstract：:Triply and doubly charged iTRAQ ( isobaric tagging for relative and absolute quantitation) labeled peptide cations from a tryptic peptide mixture of bovine carbonic anhydrase II were subjected to electron transfer ion/ion reactions to investigate the effect of charge bearing modifications associated with iTRAQ on the ...

journal_title：Journal of proteome research

authors： Han H,Pappin DJ,Ross PL,McLuckey SA

更新日期：2008-09-01 00:00:00

abstract：:Outbreaks of porcine epidemic diarrhea virus (PEDV) have caused significant lethality rates in neonatal piglets, which pose a serious threat to the swine industry worldwide. Available commercial vaccines fail to protect against the emergence of high virulence of PEDV variants. Therefore, the endemic state of the PEDV ...

journal_title：Journal of proteome research

authors： Ye Y,Zhu J,Ai Q,Wang C,Liao M,Fan H

更新日期：2019-04-05 00:00:00

abstract：:Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical ...

journal_title：Journal of proteome research

authors： Jones EA,Schmitz N,Waaijer CJ,Frese CK,van Remoortere A,van Zeijl RJ,Heck AJ,Hogendoorn PC,Deelder AM,Altelaar AF,Bovée JV,McDonnell LA

更新日期：2013-04-05 00:00:00

abstract：:As a recently validated reversible post translational modification, lysine malonylation regulates diverse cellular processes from bacteria to mammals, but its existence and function in photosynthetic organisms remain unknown. Cyanobacteria are the most ancient group of photosynthetic prokaryotes and contribute about 5...

journal_title：Journal of proteome research

authors： Ma Y,Yang M,Lin X,Liu X,Huang H,Ge F

更新日期：2017-05-05 00:00:00

abstract：:Fulminant type 1 diabetes (FT1DM) is a relatively new clinical entity featured by acute destruction of pancreatic beta cells. Clinical consequences of FT1DM could be fatal when timely medications are not provided, suggesting the particular importance of rapid and accurate diagnosis. Here we report a serum metabonomics...

journal_title：Journal of proteome research

authors： Lu J,Zhou J,Bao Y,Chen T,Zhang Y,Zhao A,Qiu Y,Xie G,Wang C,Jia W,Jia W

更新日期：2012-09-07 00:00:00

abstract：:Tryptic digestion of biotinylated Lys-C peptides followed by affinity chromatography allows the selective isolation of lysine-free tryptic peptides delimited by arginine residues (RRnK peptides). In silico analysis revealed that RRnK peptides represent 87% of the whole proteomes and their specific isolation simplifies...

journal_title：Journal of proteome research

authors： Sánchez A,González LJ,Ramos Y,Betancourt L,Gil J,Besada V,Fernández-de-Cossio J,Alvarez F,Padrón G

更新日期：2006-05-01 00:00:00

abstract：:Linear, short-chain polyfluorinated and perfluorinated alkyl compounds, often referred to as PFCs, have been in worldwide use as surfactants and polymer precursors for decades, and environmental dispersal of these highly persistent compounds represents a public health threat. Whereas ubiquitous low-level exposure to t...

journal_title：Journal of proteome research

authors： Hansmeier N,Chao TC,Herbstman JB,Goldman LR,Witter FR,Halden RU

更新日期：2015-01-02 00:00:00

abstract：:The network of the fibrillar collagens I, III, and V, extracted from fetal calf skin and cleaved with cyanogen bromide, was studied by means of ultraviolet matrix-assisted laser desorption ionization time-of-flight mass spectrometry (UV-MALDI MS). Nearly all of the expected cyanogen bromide peptides of the different a...

journal_title：Journal of proteome research

authors： Henkel W,Dreisewerd K

更新日期：2007-11-01 00:00:00

abstract：:Enzyme-mediated 18O/16O differential labeling of proteome samples often suffers from incomplete exchange of the carboxy-terminus oxygen atoms, resulting in ambiguity in the measurable abundance differences. In this study, an 18O/16O labeling strategy was optimized for and applied to the solution-based comparative anal...

journal_title：Journal of proteome research

authors： Blonder J,Hale ML,Chan KC,Yu LR,Lucas DA,Conrads TP,Zhou M,Popoff MR,Issaq HJ,Stiles BG,Veenstra TD

更新日期：2005-03-01 00:00:00

abstract：:The GalNAc O-glycosylation on Ser/Thr residues of extracellular proteins has not been well characterized from a proteomics perspective. We previously reported a sialic acid capture-and-release protocol to enrich tryptic N- and O-glycopeptides from human cerebrospinal fluid glycoproteins using nano-LC-ESI-MS/MS with co...

journal_title：Journal of proteome research

authors： Halim A,Rüetschi U,Larson G,Nilsson J

更新日期：2013-02-01 00:00:00

abstract：:The ability of concentrated formic acid to formylate reactive amino acid residues is known from previous reports. In contrast, solvents containing a low concentration of formic acid are generally recognized as a safe environment for proteomic applications. The primary objective of this study was to explain the excessi...

journal_title：Journal of proteome research

authors： Lenčo J,Khalikova MA,Švec F

更新日期：2020-03-06 00:00:00

abstract：:A common animal model of chemical hepatocarcinogenesis was used to demonstrate the potential identification of carcinogenicity related protein signatures/biomarkers. Therefore, an animal study in which rats were treated with the known liver carcinogen N-nitrosomorpholine (NNM) or the corresponding vehicle was evaluate...

journal_title：Journal of proteome research

authors： Beyer S,Walter Y,Hellmann J,Kramer PJ,Kopp-Schneider A,Kroeger M,Ittrich C

更新日期：2006-02-01 00:00:00

abstract：:Ovarian carcinoma is the most lethal gynecological malignancy in worldwide. The discovery of reliable marker for early detection of ovarian carcinoma is critical for increasing patient's survival because high mortality rate is associated with late diagnosis of this tumor. In the present study, we performed comparative...

journal_title：Journal of proteome research

authors： Chung KH,Lee DH,Kim Y,Kim TH,Huh JH,Chung SG,Lee S,Lee C,Ko JJ,An HJ

更新日期：2010-01-01 00:00:00

abstract：:Somatic embryo development (SED) in upland cotton shows low frequencies of embryo maturation and plantlet regeneration. Progress in increasing the regeneration rate has been limited. Here a global analysis of proteome dynamics between globular and cotyledonary embryos was performed using isobaric tags for relative and...

journal_title：Journal of proteome research

authors： Ge X,Zhang C,Wang Q,Yang Z,Wang Y,Zhang X,Wu Z,Hou Y,Wu J,Li F

更新日期：2015-01-02 00:00:00

abstract：:Human milk is a rich source of bioactive proteins that support the early growth and development of the newborn. Although the major components of the protein fraction in human milk have been studied, the expression and relative abundance of minor components have received limited attention. We examined the expression of...

journal_title：Journal of proteome research

authors： Liao Y,Alvarado R,Phinney B,Lönnerdal B

更新日期：2011-04-01 00:00:00

abstract：:Chronic kidney disease (CKD) has emerged as a major public health problem worldwide. It frequently progresses to end-stage renal disease, which is related to very high cost and mortality. Novel biomarkers can provide insight into the novel mechanism, facilitate early detection, and monitor progression of CKD and its r...

journal_title：Journal of proteome research

authors： Zhang ZH,Chen H,Vaziri ND,Mao JR,Zhang L,Bai X,Zhao YY

更新日期：2016-10-07 00:00:00

abstract：:Mutagenesis through fast neutron (FN) radiation of soybean resulted in a mutant with a 15% increase in seed protein content. A comparative genomic hybridization analysis confirmed that the mutant is lacking 24 genes located at chromosomes 5 and 10. A tandem mass tag-based proteomic profiling of the wild type and the F...

journal_title：Journal of proteome research

authors： Islam N,Krishnan HB,Natarajan S

更新日期：2020-10-02 00:00:00

abstract：:To comprehensively study autoantibodies in patients with hepatocellular carcinoma (HCC), we used an approach-based serology and proteomics technologies. Total proteins extracted from HepG2 cells and HepG2.2.15 cells were separated by two-dimensional gel electrophoresis (2DE) and then transferred onto polyvinylidene di...

journal_title：Journal of proteome research

authors： Li L,Chen SH,Yu CH,Li YM,Wang SQ

更新日期：2008-02-01 00:00:00

abstract：:Monoassociation of germfree Interleukin 10 gene deficient (IL-10-/-) 129SvEv but not wild-type mice with Enterococcus faecalis induces severe chronic colitis. Bacterial strain-specific effects on the development of chronic intestinal inflammation are not understood. We investigated the molecular mechanisms of E. faeca...

journal_title：Journal of proteome research

authors： Hoffmann M,Kim SC,Sartor RB,Haller D

更新日期：2009-03-01 00:00:00

abstract：:Major depressive disorder (MDD) is a socially detrimental psychiatric disorder, contributing to increased healthcare expenditures and suicide rates. However, no empirical laboratory-based tests are available to support the diagnosis of MDD. In this study, a NMR-based plasma metabonomic method for the diagnosis of MDD ...

journal_title：Journal of proteome research

authors： Zheng P,Gao HC,Li Q,Shao WH,Zhang ML,Cheng K,Yang DY,Fan SH,Chen L,Fang L,Xie P

更新日期：2012-03-02 00:00:00

abstract：:Elevated atmospheric CO2 and nitrogen are major environmental factors affecting shoot growth. The objectives of this study are to determine the interactive effects of elevated CO2 and nitrogen on leaf growth in tall fescue ( Festuca arundinacea) and to identify major proteins and associated metabolic pathways underlyi...

journal_title：Journal of proteome research

authors： Yu J,Fan N,Li R,Zhuang L,Xu Q,Huang B

更新日期：2019-06-07 00:00:00

abstract：:The majority of mitochondrial preproteins are targeted via N-terminal presequences that are cleaved upon import into the organelle. The essential mitochondrial processing protease (MPP) is assumed to cleave the majority of incoming precursors; however, only a small fraction of mitochondrial precursors have been experi...

journal_title：Journal of proteome research

authors： Burkhart JM,Taskin AA,Zahedi RP,Vögtle FN

更新日期：2015-11-06 00:00:00

abstract：:The notion of a gamete recognition system that alerts females to the presence of gametes in their reproductive tract profoundly influences our understanding of the physiology of events leading to conception and the bearing of offspring. Here, we show that the female responds to gametes within her tract by modulating t...

journal_title：Journal of proteome research

authors： Georgiou AS,Snijders AP,Sostaric E,Aflatoonian R,Vazquez JL,Vazquez JM,Roca J,Martinez EA,Wright PC,Fazeli A

更新日期：2007-12-01 00:00:00