Abstract：
BACKGROUND:Neonatal hypoxic-ischemic encephalopathy is still a significant cause of neonatal death and neurodevelopmental disabilities, such as cerebral palsy, mental delay, and epilepsy. After the introduction of therapeutic hypothermia, the prognosis of hypoxic-ischemic encephalopathy has improved, with reduction of death and disabilities. However, few studies evaluated whether hypothermia affects rate and severity of post-neonatal epilepsy. We evaluated rates, characteristics and prognostic markers of post-neonatal epilepsy in infants with moderate to severe hypoxic-ischemic encephalopathy treated or not with therapeutic hypothermia. METHODS:We analyzed clinical data, EEG recordings, cerebral Magnetic Resonance Imaging (MRI) and outcome in 23 cooled and 26 non-cooled asphyxiated neonates (≥36 weeks' gestation), admitted from 2004 to 2012. RESULTS:Among 49 neonates 11 (22%) had post-neonatal epilepsy, of which 9 (18%) were non-cooled and 2 (4%) were cooled (p=0.05). Six of 11 infants (55%) had West syndrome, 4 (36%) had focal epilepsy and 1 (9%) had Lennox- Gastaut syndrome. At multiple logistic regression analysis MRI pattern significantly correlated with post-neonatal epilepsy (OR 0.19, 95% CI 0.04-0.88, p=0.03). Extensive lesions in basal ganglia and thalami plus cortical and white matter were associated with post-neonatal epilepsy. CONCLUSIONS:Only perinatal asphyxia with extensive lesions in basal ganglia and thalami plus cortical and white matter lesion conveys an high risk for early and severe post-neonatal epilepsy. Moreover therapeutic hypothermia is associated with a decrease of the risk of developing post-neonatal epilepsy.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Lugli L,Balestri E,Berardi A,Guidotti I,Cavalleri F,Todeschini A,Pugliese M,Muttini Della Casa E,Lucaccioni L,Ferrari Fdoi
10.23736/S0026-4946.18.05224-6subject
Has Abstractpub_date
2018-07-02 00:00:00eissn
0026-4946issn
1827-1715pii
S0026-4946.18.05224-6pub_type
杂志文章abstract：AIM:Optic pathway gliomas (OPG) are the predominant intracranial tumours associated with neurofibromatosis type 1 (NF1). The aim of this study was to evaluate the prevalence and the outcome of OPG in 200 NF1 patients (122 males and 78 females, aged 1-25 years) followed up to 16 years (mean of 6 years). METHODS:All chi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:To evaluate if vesicoureteral reflux (VUR) contralateral to the multicystic dysplastic kidney can interfere with the compensatory renal hypertrophy. METHODS:Twenty-seven patients (17 males, 10 females) with multicystic dysplastic kidney (MDK) (14 on the right, 13 on the left) have been treated at the Nephro...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:The lipidaemic profile has been evaluated in a series of 603 healthy children aged 13-14, within a programme for the prevention of atherosclerotic disease commenced in November 1980 at Health Unit 66 of the Region of Piedmont. Hyperlipaemia is among the environmental risk factors for ATS and more than any of the other...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：AIM:Childhood leukaemia treatment contains multiple chemotherapeutic agents in high doses that can cause severe toxic effects on heart and other vital organs. In this respect patients taking cancer chemotherapy are followed for these adverse effects. Echocardiographic myocardial performance index (MPI) was reported as ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2007-04-01 00:00:00
abstract：:Intra-abdominal lymphangiomas are rare benign tumours that can cause various symptoms, mainly during childhood. They are diagnosed by ultrasonography, CT scanning or at laparotomy; ultrasonographic examination often shows a voluminous tumoral cystic formation with septa. The location of the cyst may be determined eith...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2006-02-01 00:00:00
abstract：:The dominant cause of mortality, morbidity and hospitalization worldwide is cardiac complications, and are the major public health problem in adult populations. The worldwide research is being focused on the idea that cardiovascular disease is an early life pathological state. Early unfavorable exposures, acting in di...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4946.16.04713-7
更新日期：2017-06-01 00:00:00
abstract：:More than one million neonatal deaths every year in the world are attributable to infection. In nurseries, infections occur with a reported incidence of 0.3-3%; in Neonatal Intensive Care Units (NICUs) the reported incidence is 7-24.5%, and up to 40% in newborns with birth weight less than 1000 g or gestational age at...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2013-02-01 00:00:00
abstract：:Infants born prematurely before 37 weeks of gestational age (GA) have particular anatomical, immunological and metabolic characteristics that predispose them, even in the absence of diseases at birth, to severe morbidity. Respiratory syncytial virus (RSV) is the leading cause of hospitalization for lower respiratory t...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4946.18.05300-8
更新日期：2018-12-01 00:00:00
abstract：AIM:The objective of this paper is an empirical analysis of mother-infant feeding interactions through an observational instrument (Feeding Scale), which is applied to the videotape of a feeding session. METHODS:Three samples of mothers and their children have been examined (104 couples with children ranging in age fr...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2003-06-01 00:00:00
abstract：:Cystic fibrosis (CF) is a genetic disease associated with recurrent lung infections, that represent a major cause of mortality and morbidity. Cystic fibrosis requires frequent antibiotic treatments, sometimes by mouth or via aerosol but often via the intravenous route. Totally implanted venous access devices (ports) a...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2009-10-01 00:00:00
abstract：BACKGROUND:In this paper we present growth height standards obtained by an auxological study on a primary school population of central Italy (Lazio), in the 1991-1992 and 1992-1993 school-years. METHODS:4,175 children were included in the study: 2,024 females and 2,151 males, aged from 6 to 11 years. The sampling rate...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：INTRODUCTION:Online grooming is an active communicative entrapment network involving a wide range of techniques. The interactions that groomers have with minors online are complex. The purpose of the present literature review is to contribute to the existing knowledge base regarding online sex offender typologies, pred...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.20.05621-2
更新日期：2020-05-15 00:00:00
abstract：:Cerebral palsy (CP) is a description of a spectrum of central nervous system (CNS) impairments that affect mobility, communication, intellectual ability, and neurobehavior as a result of developmental brain dysfunction. CP is the most common contributor to motor disability in children with prevalence of about 2-3/1000...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2009-08-01 00:00:00
abstract：:In 1967 a baby was observed who presented post-natal progressive growth deficit, mental retardation, craniofacial dysmorphias and other malformations which didn't form part of the syndromes till then known. However the first description of patients with this combination of anomalies dates back to 1981, when Niikawa an...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:A drug-related problem (DRP) may be defined as "an event or circumstance involving drug therapy that actually or potentially interferes with the desired health outcome". Our aim was to determine the frequency and characteristics of DRPs in pediatric patients admitted to a tertiary cardiac care center in the ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2016-04-01 00:00:00
abstract：:The management of neonatal fungal infections poses several challenges, including the fact that the choices of available agents are limited, given the paucity of data relating to the use of newer antifungal agents in the group of infants. The information summarized herein represents in part the consensus of a group of ...
journal_title：Minerva pediatrica
pub_type： 共识发展会议,杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：:The introduction of the new diagnostic tools for neuroimaging has resulted in the early recognition of congenital brain tumors. In the present report we describe 39 children, in whom the diagnosis of an intracranial tumor has been obtained during the first 12 months of life. These patients represent 14.4% of a pediatr...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND:Pulmonary hypertension in childhood is uncommon. It can be idiopathic or secondary to other pathologies (cardiovascular, skeletric,...). CASE DESCRIPTION:We report on a 9 year old girl suffering from pulmonary hypertension due to severe dorso-lumbar scoliosis. CONCLUSIONS:We discuss the etiopathogenetic re...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：AIM:Myelomeningocele (MMC), among others functions, affects colorectal motility and bowel emptying, and often leads to constipation, faecal incontinence, or a combination of both. We investigated the benefits of transanal irrigation (TI) in children with MMC through the radiological study of intestinal transit time. M...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Previous trials, performed in subjects affected by recurrent streptococcal pharyngo-tonsillar infection, have shown that the use for 90 days of Streptococcus salivarius K12 (K12), an oral colonizing probiotic producing lantibiotic bacteriocins, reduces the occurrence of streptococcal and viral pharyngitis an...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.18.05182-4
更新日期：2018-06-01 00:00:00
abstract：:West syndrome is a generalized epilepsy syndrome composed of infantile spasms and onset is usually within the first year of life. Although West syndrome is well known clinical epileptic syndrome, there is no agreement about the first- and second-line treatments. In the last years a great progress in the development of...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：:Certain humoral and cellular immunological parameters were assessed in patients with either pure atopic dermatitis or dermatitis combined with asthma in order to discover if there were any significant differences between the two clinical forms. The study was conducted on 15 children of both sexes who were investigated...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:Intrauterine growth restriction (IUGR) is caused by fetal growth below what is normal for its genetic potential. Recent studies have shown a distinct association between changes in umbilical artery flow in IUGR subjects and an increased risk of respiratory morbidity and was to find the impact of IUGR on the ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.17.04965-9
更新日期：2017-05-31 00:00:00
abstract：AIM:Pectus excavatum is the commonest thoracic congenital malformation, but its treatment remains not well known. The authors present the results of the mini-invasive repair at G. Gaslini Institute of Genoa, Italy. METHODS:Nuss mini-invasive repair avoids anterior scars. The correction is achieved by the introduction ...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2008-08-01 00:00:00
abstract：:The Femoral hypoplasia - unusual facies syndrome (FHUF) or Femoral - facial syndrome (FFS) was at first described in 1975. Up to now about 60 cases have been reported. According to our knowledge only 4 cases have had congenital central nervous system's malformations, furthermore the main stages of psychomotor developm...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2011-08-01 00:00:00
abstract：INTRODUCTION:At present, morphine is the most commonly used first-line therapy to treat Neonatal Abstinence Syndrome (NAS). Unfortunately, there is still lack of evidence and consensus to guide pharmacologic therapy for NAS. In this review, we provide an overview on dosing regimens of morphine currently reported to tre...
journal_title：Minerva pediatrica
pub_type： 杂志文章,评审
doi：10.23736/S0026-4946.17.04928-3
更新日期：2019-06-01 00:00:00
abstract：AIM:The prevalence of systemic reactions (SR) to Hymenoptera stings in children was estimated in values lower than 1% in early studies but much higher in recent surveys. We evaluated the current prevalence and the incidence of SR and large local reactions (LLR) to Hymenoptera stings in children in Italy. METHODS:The d...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2014-08-01 00:00:00
abstract：AIM:The aim of this study was to evaluate the influence of colostomy type on morbidity during the treatment of anorectal malformations. METHODS:Sixty-eight infants (male: female ratio 1.3:1) with anorectal malformations that required colostomy were treated in our clinics during the period 1991-2001. Of these patients,...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:In epileptic patients with motor disability, it's difficult to disentangle the effects of antiepileptic drugs (AEDs) on bone health from those provoked by impaired mobility. The aim of this study was to evaluate the effects of AEDs on bone mineral status by phalangeal quantitative ultrasound (QUS), a no-radi...
journal_title：Minerva pediatrica
pub_type： 杂志文章
doi：10.23736/S0026-4946.18.05235-0
更新日期：2019-05-23 00:00:00
abstract：:Aspecific chronic diarrhea is one of the most common causes of protracted diarrhea in infancy. The pathology is characterised by an increased frequency of daily bowel movement with half-formed feces; it is not associated to malabsorption syndrome or enteric infections and appears to be correlated to an unbalanced diet...
journal_title：Minerva pediatrica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-04-01 00:00:00
