Abstract:
BACKGROUND:Clinical studies during pregnancy are rare due to ethical and practical limitations. Giving pregnant females the same dosing regimen used in adult males or nonpregnant females is inappropriate. Pregnancy physiologically-based pharmacokinetic modeling is a powerful tool that can be used to refine pharmacotherapy during pregnancy. OBJECTIVE:This work provides a review of the current status of application of physiologically based pharmacokinetic models in developing dosing regimens in pregnant women. METHODS:A structured search was done on Scholar Google, Science Direct and PubMed. The articles searched were those providing physiological, anatomical and biochemical data needed for pregnancy physiologically-based pharmacokinetic models or utilizing these models to evaluate the effect of pregnancy on drugs pharmacokinetics. Key words used for search include: PBPK and pregnancy, pharmacokinetic during pregnancy, ethics of pregnancy studies. The found articles were evaluated in terms of main pharmacokinetic features of the drug that were affected by pregnancy, the structure of the model, the software platform used and quality of predicted maternal and fetal exposure. RESULTS:Pregnancy physiologically-based pharmacokinetic models can be used to optimize effective and safe dosing regimens needed during pregnancy. Different model structures have been successfully used for this purpose using different modeling software. CONCLUSION:More work is needed to fill the gaps in knowledge needed to more accurately and mechanistically simulate simultaneous exposure of the pregnant mother and her fetus/ embryo to drugs using pregnancy physiologicallybased pharmacokinetic modeling approach.
journal_name
Curr Drug Metabjournal_title
Current drug metabolismauthors
Alsmadi MM,Idkaidek Ndoi
10.2174/1389200219666180702104034subject
Has Abstractpub_date
2018-01-01 00:00:00pages
972-978issue
12eissn
1389-2002issn
1875-5453pii
CDM-EPUB-91408journal_volume
19pub_type
杂志文章,评审abstract:BACKGROUND:Drug-induced cholestasis is a risk factor in the progression of drug candidates, and poses a serious health hazard if not detected before going into a human. Intrahepatic accumulation of Bile Acids (BAs) represents a characteristic phenomenon associated with drug-induced cholestasis. METHODS:This review wil...
journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/1389200219666180427165035
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abstract::Currently the major research highlights of bioengineering and medical technology are directed towards development of improved diagnostic techniques to screen complex diseases. Screening requirements are to identify the cause of illnesses, monitor improvement or progression of the state of diseases such as cancer, card...
journal_title:Current drug metabolism
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doi:
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journal_title:Current drug metabolism
pub_type: 杂志文章
doi:10.2174/138920008783884768
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/1389200013338306
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/138920010791636202
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Current drug metabolism
pub_type: 杂志文章
doi:10.2174/138920005774832632
更新日期:2005-12-01 00:00:00
abstract:: ...
journal_title:Current drug metabolism
pub_type: 社论
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更新日期:2018-01-01 00:00:00
abstract::For the pharmaceutical industry, one of the challenges in evaluating the risk of future compound attrition at the discovery stage is the successful prediction of the major routes of clearance in humans. For compounds cleared by metabolism, such information will help to avoid the development of compounds that will exhi...
journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2003-12-01 00:00:00
abstract:AIMS:Because of the high affinity of these animal neurotoxin proteins for some special target site, they were usually used as pharmacological tools and therapeutic agents in medicine to gain deep insights into the function of the nervous system. BACKGROUND AND OBJECTIVE:The animal neurotoxin proteins are one of the mo...
journal_title:Current drug metabolism
pub_type: 杂志文章
doi:10.2174/1389200221666200520090555
更新日期:2020-01-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2000-09-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:
更新日期:2013-01-01 00:00:00
abstract::Photodynamic therapy (PDT) combines photosensitizer, visible light and oxygen, which has the characteristics of high selectivity, minimal invasiveness, low side effect, and allowing repetitive application. The photophysics and mechanisms leading to cell death mediated by PDT have been studied extensively, and PDT has ...
journal_title:Current drug metabolism
pub_type: 杂志文章
doi:10.2174/138920009790274559
更新日期:2009-10-01 00:00:00
abstract::Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important role in drug discovery and development and several reliable in vitro ADME models are available. Recently higher throughput in vitro ADME screening facilities have been established in order to be able to evaluate an appreciable f...
journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/138920008786485092
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Methotrexate (MTX) is a folate analogue with high therapeutic efficiency in the treatment of cancers and autoimmune diseases. The efficacy and toxicity of MTX may be altered by genetic polymorphisms in genes involved in MTX metabolic pathway. Personalized pharmacotherapy based on gene polymorphisms enables a...
journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/1389200219666171227201047
更新日期:2018-01-01 00:00:00
abstract::Toxicogenomics is defined as an integration of genomics (transcriptomics, proteomics and metabolomics) and toxicology. It is a scientific field that studies how the genome is involved in responses to environmental stressors and toxicants. It combines studies of mRNA expression, cell and tissue-wide protein expression ...
journal_title:Current drug metabolism
pub_type: 杂志文章,评审
doi:10.2174/138920008783884696
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:The use of psychoactive substances is one of the most dangerous social problems worldwide. Nicotine dependence results from the interaction between neurobiological, environmental and genetic factors. Serotonin is a neurotransmitter that has a wide range of central nervous system activities. The serotonin tra...
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pub_type: 杂志文章
doi:10.2174/1389200221666200620201348
更新日期:2020-01-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Current drug metabolism
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-11-01 00:00:00
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journal_title:Current drug metabolism
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更新日期:2003-10-01 00:00:00
abstract::5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many physiological and behavioral changes. 5-MeO-DMT is O-demethylated by polymorphic cytochrome P450 2D6 (CYP2D6) to an active metab...
journal_title:Current drug metabolism
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更新日期:2010-10-01 00:00:00
abstract::Etoposide (VP-16), a DNA topoisomerase II poison widely used as an antineoplastic agent is also known to cause leukemia. One of its major metabolic pathways involves O-demethylation to etoposide catechol (etoposide-OH) by cytochrome P450 3A4 (CYP3A4). The catechol metabolite can undergo sequential one- and two-electro...
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更新日期:2006-12-01 00:00:00
abstract::Transplantation has become an established and successful therapy. Rejections and infections are the principal immune-related complications in the post-transplant course. A reliable and early diagnosis is necessary to prevent graft failure and patient morbidity. Despite the immunologic nature of these complications the...
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