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RGG/RG Motif Regions in RNA Binding and Phase Separation.

Abstract：

:RGG/RG motifs are RNA binding segments found in many proteins that can partition into membraneless organelles. They occur in the context of low-complexity disordered regions and often in multiple copies. Although short RGG/RG-containing regions can sometimes form high-affinity interactions with RNA structures, multiple RGG/RG repeats are generally required for high-affinity binding, suggestive of the dynamic, multivalent interactions that are thought to underlie phase separation in formation of cellular membraneless organelles. Arginine can interact with nucleotide bases via hydrogen bonding and π-stacking; thus, nucleotide conformers that provide access to the bases provide enhanced opportunities for RGG interactions. Methylation of RGG/RG regions, which is accomplished by protein arginine methyltransferase enzymes, occurs to different degrees in different cell types and may regulate the behavior of proteins containing these regions.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Chong PA,Vernon RM,Forman-Kay JD

doi

10.1016/j.jmb.2018.06.014

subject

Has Abstract

pub_date

2018-11-02 00:00:00

pages

4650-4665

issue

23

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(18)30610-7

journal_volume

430

pub_type

杂志文章,评审

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