Abstract:
OBJECTIVES:A reliable tool to evaluate flow is paramount in systemic sclerosis (SSc). We describe herein on the one hand a systematic literature review on the reliability of laser speckle contrast analysis (LASCA) to measure the peripheral blood perfusion (PBP) in SSc and perform an additional pilot study, investigating the intra- and inter-rater reliability of LASCA. METHODS:A systematic search was performed in 3 electronic databases, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In the pilot study, 30 SSc patients and 30 healthy subjects (HS) underwent LASCA assessment. Intra-rater reliability was assessed by having a first anchor rater performing the measurements at 2 time-points and inter-rater reliability by having the anchor rater and a team of second raters performing the measurements in 15 SSc and 30 HS. The measurements were repeated with a second anchor rater in the other 15 SSc patients, as external validation. RESULTS:Only 1 of the 14 records of interest identified through the systematic search was included in the final analysis. In the additional pilot study: intra-class correlation coefficient (ICC) for intra-rater reliability of the first anchor rater was 0.95 in SSc and 0.93 in HS, the ICC for inter-rater reliability was 0.97 in SSc and 0.93 in HS. Intra- and inter-rater reliability of the second anchor rater was 0.78 and 0.87. CONCLUSIONS:The identified literature regarding the reliability of LASCA measurements reports good to excellent inter-rater agreement. This very pilot study could confirm the reliability of LASCA measurements with good to excellent inter-rater agreement and found additionally good to excellent intra-rater reliability. Furthermore, similar results were found in the external validation.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Cutolo M,Vanhaecke A,Ruaro B,Deschepper E,Ickinger C,Melsens K,Piette Y,Trombetta AC,De Keyser F,Smith V,EULAR Study Group on Microcirculation in Rheumatic Diseases.doi
10.1016/j.autrev.2018.01.023subject
Has Abstractpub_date
2018-08-01 00:00:00pages
775-780issue
8eissn
1568-9972issn
1873-0183pii
S1568-9972(18)30134-4journal_volume
17pub_type
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journal_title:Autoimmunity reviews
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pub_type: 杂志文章,评审
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