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Intraoperative detection of circulating tumor cells in pulmonary venous blood during metastasectomy for colorectal lung metastases.

Abstract：

:Circulating tumor cells (CTC) have been studied extensively in various tumor types and are a well-established prognosticator in colorectal cancer (CRC). This is the first study to isolate CTC directly from the tumor outflow in secondary lung tumors. For this purpose in 24 patients with CRC who underwent pulmonary metastasectomy in curative intent blood was drawn intraoperatively from the pulmonary vein (tumor outflow). In 22 samples CTC-enumeration was performed using CellSieve-microfilters and immunohistochemical- and Giemsa-staining. Additionally 10 blood samples were analyzed using the CellSearch-System. We could isolate more CTC in pulmonary venous blood (total 41, range 0-15) than in samples taken from the periphery at the same time (total 6, range 0-5, p = 0.09). Tumor positive lymph nodes correlated with presence of CTC in pulmonary venous blood as in all cases CTC were present (p = 0.006). Our findings suggest a tumor cell release from pulmonary metastases in CRC and a correlation of CTC isolated from the tumor outflow with established negative prognostic markers in metastasized CRC. The presented data warrant further investigations regarding the significance of local tumor compartments when analyzing circulating markers and the possibility of tumor cell shedding from secondary lung tumors.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Le UT,Bronsert P,Picardo F,Riethdorf S,Haager B,Rylski B,Czerny M,Beyersdorf F,Wiesemann S,Pantel K,Passlick B,Kaifi JT,Schmid S

doi

10.1038/s41598-018-26410-8

subject

Has Abstract

pub_date

2018-06-08 00:00:00

pages

8751

issue

1

issn

2045-2322

pii

10.1038/s41598-018-26410-8

journal_volume

8

pub_type

杂志文章

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