The effect of glutamine infusion on the inflammatory response and HSP70 during human experimental endotoxaemia.

abstract：:Tight glycaemic control has emerged as a major focus in critical care. However, the struggle to repeat, improve and standardize the results of the initial landmark studies is ongoing. The prospective computerized glycaemic control study by Shulman et al. highlights two emerging and often overlooked aspects of intensiv...

journal_title：Critical care (London, England)

authors： Chase JG,Shaw GM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The dysregulated host immune response that defines sepsis varies as a function of both the immune status of the host and the distinct nature of the pathogen. The degree to which immunocompromising comorbidities or immunosuppressive medications affect the immune response to infection is poorly understood beca...

journal_title：Critical care (London, England)

authors： Greenberg JA,Hrusch CL,Jaffery MR,David MZ,Daum RS,Hall JB,Kress JP,Sperling AI,Verhoef PA

更新日期：2018-04-25 00:00:00

abstract：INTRODUCTION:Coagulation abnormalities are frequent in sepsis. Conventional coagulation assays, however, have several limitations. A surge of interest exists in the use of point-of-care tests to diagnose hypo- and hypercoagulability in sepsis. METHODS:MEDLINE, EMBASE, and the Cochrane Library were searched from 1 Janu...

journal_title：Critical care (London, England)

authors： Müller MC,Meijers JC,Vroom MB,Juffermans NP

更新日期：2014-02-10 00:00:00

abstract：INTRODUCTION:The gut is often considered as the motor of critical illness through bacterial translocation, which amplifies the inflammatory response and alters the immune status. However, systemic bacterial translocation was rarely proven and endotoxin measurement only reflects translocation of Gram-negative-derived pr...

journal_title：Critical care (London, England)

authors： Kim OY,Monsel A,Bertrand M,Cavaillon JM,Coriat P,Adib-Conquy M

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Data on the epidemiology and management of anorexia nervosa (AN) in the intensive care unit (ICU) are scarce. The aim of this study was to evaluate the prevalence and associated morbidity and mortality of AN in French ICUs. METHODS:We randomly selected 30 ICUs throughout France. Thereafter, we retrospecti...

journal_title：Critical care (London, England)

authors： Vignaud M,Constantin JM,Ruivard M,Villemeyre-Plane M,Futier E,Bazin JE,Annane D,AZUREA group (AnorexieRea Study Group).

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The aim of the present multicenter study was to assess long term (36 months) health related quality of life in patients after critical illness, compare ICU survivors health related quality of life to that of the general population and examine the impact of pre-existing disease and factors related to ICU ca...

journal_title：Critical care (London, England)

authors： Orwelius L,Nordlund A,Nordlund P,Simonsson E,Bäckman C,Samuelsson A,Sjöberg F

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Inflammation may critically affect mechanisms of liver injury in acetaminophen (APAP) hepatotoxicity. Kupffer cells (KC) play important roles in inflammation, and KC depletion confers protection at early time points after APAP treatment but can lead to more severe injury at a later time point. It is possib...

journal_title：Critical care (London, England)

authors： Yang R,Zou X,Koskinen ML,Tenhunen J

更新日期：2012-01-16 00:00:00

abstract：BACKGROUND:Impaired microcirculatory perfusion and tissue oxygenation during critical illness are associated with adverse outcome. The aim of this study was to detect alterations in tissue oxygenation or microvascular reactivity and their ability to predict outcome in critically ill patients using thenar near-infrared ...

journal_title：Critical care (London, England)

authors： Donati A,Damiani E,Domizi R,Scorcella C,Carsetti A,Tondi S,Monaldi V,Adrario E,Romano R,Pelaia P,Singer M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) affects a large proportion of the critically ill and is associated with worse patient outcomes. Early identification of AKI can lead to earlier initiation of supportive therapy and better management. In this study, we evaluate the impact of computerized AKI decision support tool int...

journal_title：Critical care (London, England)

authors： Bourdeaux C,Ghosh E,Atallah L,Palanisamy K,Patel P,Thomas M,Gould T,Warburton J,Rivers J,Hadfield J

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Higher inspiratory airway pressures are associated with worse outcomes in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). This relationship, however, has not been well investigated in patients without ARDS. We hypothesized that higher driving pressures (ΔP) and plateau p...

journal_title：Critical care (London, England)

authors： Sahetya SK,Mallow C,Sevransky JE,Martin GS,Girard TD,Brower RG,Checkley W,Society of Critical Care Medicine Discovery Network Critical Illness Outcomes Study Investigators.

更新日期：2019-11-21 00:00:00

abstract：INTRODUCTION:The interdependence between endotoxemia, gram negative (GN) bacteremia and mortality has been extensively studied. Underlying patient risk and GN bacteremia types are possible confounders of the relationship. METHODS:Published studies with ≥ 10 patients in either ICU or non-ICU settings, endotoxemia detec...

journal_title：Critical care (London, England)

authors： Hurley JC,Guidet B,Offenstadt G,Maury E

更新日期：2012-08-07 00:00:00

abstract：INTRODUCTION:The present study assessed the opinion of general practitioners (GPs) concerning their relationships with intensivists. METHODS:An anonymous questionnaire was mailed to 7,239 GPs. GPs were asked about their professional activities, postgraduate intensive care unit (ICU) training, the rate of patient admit...

journal_title：Critical care (London, England)

authors： Etesse B,Jaber S,Mura T,Leone M,Constantin JM,Michelet P,Zoric L,Capdevila X,Malavielle F,Allaouchiche B,Orban JC,Fabbro-Peray P,Lefrant JY,AzuRéa Group.

更新日期：2010-01-01 00:00:00

abstract：:Severe sepsis is more and more frequent, especially because of an increased rate of immunocompromised patients. Despite the improvement in the overall prognosis of HIV/AIDS patients and the improvement of global ICU care, the prognosis of HIV/ADS patients hospitalized in ICU with severe sepsis remained poor. This situ...

journal_title：Critical care (London, England)

authors： Timsit JF

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Burnout has gained increasing attention worldwide; however, there is a lack of relevant research in China. This study investigated the prevalence and factors associated with burnout in physicians of the intensive care unit (ICU) in mainland China. METHODS:This cross-sectional multicenter study included crit...

journal_title：Critical care (London, England)

authors： Wang J,Hu B,Peng Z,Song H,Cai S,Rao X,Li L,Li J

更新日期：2021-01-05 00:00:00

abstract：INTRODUCTION:There is a complex interplay between changes in acid-base components and inflammation. This manuscript aims to explore associations between plasma cytokines and chemokines and acid-base status on admission to intensive care. METHODS:We conducted a prospective cohort study in a 13-bed ICU in a tertiary-car...

journal_title：Critical care (London, England)

authors： Zampieri FG,Kellum JA,Park M,Ranzani OT,Barbeiro HV,de Souza HP,da Cruz Neto LM,da Silva FP

更新日期：2014-07-17 00:00:00

abstract：INTRODUCTION:Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesi...

journal_title：Critical care (London, England)

authors： Liu YY,Lee CH,Dedaj R,Zhao H,Mrabat H,Sheidlin A,Syrkina O,Huang PM,Garg HG,Hales CA,Quinn DA

更新日期：2008-01-01 00:00:00

abstract：:There are many controversial issues surrounding ethics in study design and conduct of human subjects research. In this review we briefly touch on the origin of ethics in clinical research and how the current regulations and standards came into practice. We then discuss current controversies regarding informed consent,...

journal_title：Critical care (London, England)

authors： Huang DT,Hadian M

更新日期：2006-01-01 00:00:00

abstract：: ...

journal_title：Critical care (London, England)

authors： Honore PM,De Bels D,Kugener L,Redant S,Attou R,Gallerani A,Spapen HD

更新日期：2019-01-09 00:00:00

abstract：:Antithrombotic prophylaxis in critically ill patients frequently fails. Venous thromboembolism is associated with adverse clinical outcomes, including a prolonged intensive care unit stay and death. A potential mechanism by which critically ill patients may be predisposed to antithrombotic failure is the inability to ...

journal_title：Critical care (London, England)

authors： Crowther M,Lim W

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:For patients who survive a critical illness and have their oral endotracheal tube removed, dysphagia is highly prevalent, and without intervention, it may persist far beyond hospital discharge. This pre- and post-intervention study with historical controls tested the effects of a swallowing and oral care (SO...

journal_title：Critical care (London, England)

authors： Wu CP,Xu YJ,Wang TG,Ku SC,Chan DC,Lee JJ,Wei YC,Hsiao TY,Chen CC

更新日期：2019-11-09 00:00:00

abstract：BACKGROUND:There is growing interest in patient outcomes following critical illness, with an increasing number and different types of studies conducted, and a need for synthesis of existing findings to help inform the field. For this purpose we conducted a systematic review of qualitative studies evaluating patient out...

journal_title：Critical care (London, England)

authors： Hashem MD,Nallagangula A,Nalamalapu S,Nunna K,Nausran U,Robinson KA,Dinglas VD,Needham DM,Eakin MN

更新日期：2016-10-26 00:00:00

abstract：IMPORTANCE:The optimal approach to airway management during in-hospital cardiac arrest is unknown. OBJECTIVE:To describe hospital-level variation in endotracheal intubation during cardiopulmonary resuscitation (CPR) for in-hospital cardiac arrest and the association between hospital use of endotracheal intubation and ...

journal_title：Critical care (London, England)

authors： Bradley SM,Zhou Y,Ramachandran SK,Engoren M,Donnino M,Girotra S

更新日期：2019-05-06 00:00:00

abstract：INTRODUCTION:V(2)-receptor (V(2)R) stimulation potentially aggravates sepsis-induced vasodilation, fluid accumulation and microvascular thrombosis. Therefore, the present study was performed to determine the effects of a first-line therapy with the selective V(2)R-antagonist (Propionyl(1)-D-Tyr(Et)(2)-Val(4)-Abu(6)-Arg...

journal_title：Critical care (London, England)

authors： Rehberg S,Ertmer C,Lange M,Morelli A,Whorton E,Dünser M,Strohhäcker AK,Lipke E,Kampmeier TG,Van Aken H,Traber DL,Westphal M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Neurocritical illness is a growing healthcare problem with profound socioeconomic effects. We assessed differences in healthcare costs and long-term outcome for different forms of neurocritical illnesses treated in the intensive care unit (ICU). METHODS:We used the prospective Finnish Intensive Care Consort...

journal_title：Critical care (London, England)

authors： Raj R,Bendel S,Reinikainen M,Hoppu S,Laitio R,Ala-Kokko T,Curtze S,Skrifvars MB

更新日期：2018-09-20 00:00:00

abstract：:Large numbers of patients who survive critical illness are left with significant new cognitive impairments that are often severe and remain years after hospital discharge. In the previous issue of Critical Care, Guerra and colleagues assessed risk factors for the development of dementia after an intensive care unit (I...

journal_title：Critical care (London, England)

authors： Hopkins RO

更新日期：2013-02-06 00:00:00

abstract：:This commentary on a paper by Bendel and colleagues in the previous issue of Critical Care describes the difficulty in assessing the sufficiency of adrenal responses to endogenous, stress-induced adrenocorticotropic hormone (ACTH) release by the pituitary or to exogenous ACTH administration in the critically ill patie...

journal_title：Critical care (London, England)

authors： Groeneveld AB,Beishuizen A,Molenaar N

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Our aim in this study was to assess whether the new Glasgow Coma Scale, Age, and Systolic Blood Pressure (GAP) scoring system, which is a modification of the Mechanism, Glasgow Coma Scale, Age, and Arterial Pressure (MGAP) scoring system, better predicts in-hospital mortality and can be applied more easily...

journal_title：Critical care (London, England)

authors： Kondo Y,Abe T,Kohshi K,Tokuda Y,Cook EF,Kukita I

更新日期：2011-08-10 00:00:00

abstract：INTRODUCTION:The objective of this study was to evaluate the effects of two different mean arterial blood pressure (MAP) targets on needs for resuscitation, organ dysfunction, mitochondrial respiration and inflammatory response in a long-term model of fecal peritonitis. METHODS:Twenty-four anesthetized and mechanicall...

journal_title：Critical care (London, England)

authors： Corrêa TD,Vuda M,Takala J,Djafarzadeh S,Silva E,Jakob SM

更新日期：2013-01-30 00:00:00

abstract：:BACKGROUND: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. RESULTS: A portable, battery-powered blood analyzer was used on patients in life threatening conditions to determine pH, pCO2, pO2, sodium, potassium and ionized c...

journal_title：Critical care (London, England)

authors： Prause G,Ratzenhofer-Komenda B,Offner A,Lauda P,Voit H,Pojer H

更新日期：1997-01-01 00:00:00

abstract：:The 21st International Symposium on Intensive Care and Emergency Medicine was dominated by the results of recent clinical trials in sepsis and acute respiratory distress syndrome (ARDS). The promise of extracorporeal liver replacement therapy and noninvasive ventilation were other areas of interest. Ethical issues als...

journal_title：Critical care (London, England)

authors： Ball J,Venn R

更新日期：2001-01-01 00:00:00