EXHANCE-12: 1-year study of the exhalation delivery system with fluticasone (EDS-FLU) in chronic rhinosinusitis.

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) in aspirin-exacerbated respiratory disease (AERD) represents a recalcitrant form of sinonasal inflammation for which a multidisciplinary consensus on patient management has not been reached. Several medical interventions have been investigated, but a formal comprehensive evaluati...

journal_title：International forum of allergy & rhinology

authors： Levy JM,Rudmik L,Peters AT,Wise SK,Rotenberg BW,Smith TL

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The objective of this work was to evaluate prevalence of eosinophilic esophagitis (EoE) in the United States, and analyze prevalence of atopic disease in patients with EoE. The study design was a retrospective administrative database analysis in U.S.-based outpatient settings. METHODS:A retrospective claims...

journal_title：International forum of allergy & rhinology

authors： Benninger MS,Strohl M,Holy CE,Hanick AL,Bryson PC

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The effects of desloratadine-montelukast combination on quality of life (QoL) and nasal airflow of patients with perennial allergic rhinitis (PAR) has not been reported. The objective of this work was investigate the efficacy of desloratadine-montelukast combination on nasal obstruction and health-related qu...

journal_title：International forum of allergy & rhinology

authors： Cingi C,Oghan F,Eskiizmir G,Yaz A,Ural A,Erdogmus N

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The relationship between olfactory function, rhinencephalon and forebrain changes in Kallmann syndrome (KS) have not been adequately investigated. We evaluated a large cohort of male KS patients using Sniffin' Sticks and MRI in order to study olfactory bulb (OB) volume, olfactory sulcus (OS) depth, cortical ...

journal_title：International forum of allergy & rhinology

authors： Ottaviano G,Cantone E,D'Errico A,Salvalaggio A,Citton V,Scarpa B,Favaro A,Sinisi AA,Liuzzi R,Bonanni G,Di Salle F,Elefante A,Manara R,Staffieri A,Martini A,Brunetti A

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. It is well documented that bacteriostatic and bactericidal effects of NO are concentration-dependent. However, few data exist comparing relative susceptibility of common pathoge...

journal_title：International forum of allergy & rhinology

authors： Workman AD,Carey RM,Kohanski MA,Kennedy DW,Palmer JN,Adappa ND,Cohen NA

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Lumbar drain (LD) use in the management of cerebrospinal fluid (CSF) rhinorrhea remains controversial. We analyzed the relationship between LD placement and CSF leak recurrence after endoscopic repair. METHODS:A retrospective case series was conducted. Patients who underwent CSF leak repair from 1999 to 201...

journal_title：International forum of allergy & rhinology

authors： Caballero N,Bhalla V,Stankiewicz JA,Welch KC

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:In this prospective, multicenter, randomized, controlled, double-blind study, we investigated the impact of a mobile patient engagement application on health outcomes and quality of life in allergic rhinitis (AR) and asthma patients. METHODS:In total, 327 patients with diagnoses of persistent AR or mild-to-...

journal_title：International forum of allergy & rhinology

authors： Cingi C,Yorgancioglu A,Cingi CC,Oguzulgen K,Muluk NB,Ulusoy S,Orhon N,Yumru C,Gokdag D,Karakaya G,Çelebi Ş,Çobanoglu HB,Unlu H,Aksoy MA

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Earlier studies have suggested that patients with chronic rhinosinusitis (CRS) report worse sleep quality than population norms. What remains unknown is whether these patients are actually experiencing measurable changes in objective sleep parameters. The goal of this study was to prospectively evaluate obje...

journal_title：International forum of allergy & rhinology

authors： Alt JA,Ramakrishnan VR,Platt MP,Schlosser RJ,Storck T,Soler ZM

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:We recently demonstrated the bitter taste receptor T2R38 upregulates sinonasal mucosal innate defense in response to gram-negative quorum-sensing molecules through increased nitric oxide production and mucociliary clearance. T2R38 was initially identified in the quest to understand the variability in bitter ...

journal_title：International forum of allergy & rhinology

authors： Adappa ND,Howland TJ,Palmer JN,Kennedy DW,Doghramji L,Lysenko A,Reed DR,Lee RJ,Cohen NA

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The extracellular matrix (ECM) is a potentially important component of mucosal immunity. ECM dysregulation in chronic rhinosinusitis (CRS) is suggested by genomewide association studies identifying ECM genes as top candidates. Further support is afforded by the demonstration of increased expression of perios...

journal_title：International forum of allergy & rhinology

authors： Zhang W,Hubin G,Endam LM,Al-Mot S,Filali-Mouhim A,Desrosiers M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The objective of this case series was to report what is to the best of our knowledge the first reports of nasopharyngeal and soft palate pseudomeningoceles tracking submucosally from the sphenoid sinus. METHODS:Analysis of cases through medical records. RESULTS:Two cases of middle-aged male patients presen...

journal_title：International forum of allergy & rhinology

authors： Lieberman SM,Ojo RB,Casiano RR

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Although nasal congestion is among the most common symptoms in subjects suffering from nasal diseases, relatively few data on normal airflow resistance are available for reference, especially in healthy Chinese subjects. The aim of present study was therefore to objectively measure the normal airflow resista...

journal_title：International forum of allergy & rhinology

authors： Ren L,Zhang L,Duan S,Zhang W,Zhang Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Social determinants of health can have a substantial impact on treatment outcomes. Prior study has shown that socioeconomic status influences the likelihood of improvement in quality-of-life (QOL) following endoscopic sinus surgery (ESS). However, the impact of socioeconomic factors on changes in productivit...

journal_title：International forum of allergy & rhinology

authors： Beswick DM,Mace JC,Soler ZM,Rudmik L,Alt JA,Smith KA,Detwiller KY,Ramakrishnan VR,Smith TL

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Variants of squamous cell carcinoma (SCC) make up 15% of all cases of SCC of the upper aerodigestive tract. There are 5 main histologic variants of SCC in the head and neck region: verrucous (VSCC), papillary (PSCC), spindle cell (sarcomatoid) (SCSC), basaloid (BSCC), and adenosquamous (ASC). Conventional si...

journal_title：International forum of allergy & rhinology

authors： Vazquez A,Khan MN,Blake DM,Patel TD,Baredes S,Eloy JA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Little is known regarding the role of the microbiome of the paranasal sinuses and its contribution to sinus mucosal health and disease. Consequently, we examined the microbiome of chronic rhinosinusitis patients with polyps (CRSwNP) and a control population to provide new insights into the microbiota associa...

journal_title：International forum of allergy & rhinology

authors： Gan W,Yang F,Tang Y,Zhou D,Qing D,Hu J,Liu S,Liu F,Meng J

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Increased frequency of migraine was reported in adults with allergic rhinitis (AR). Although migraine is less common in children than in adults, it can begin in early childhood and persist into adulthood. We conducted this population-based cohort study to investigate the incidence and subsequent risk of migr...

journal_title：International forum of allergy & rhinology

authors： Wang IC,Tsai JD,Lin CL,Shen TC,Li TC,Wei CC

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METH...

journal_title：International forum of allergy & rhinology

authors： Ramsey T,Lai W,Svider PF,Hojjat H,Eloy JA,Folbe AJ

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susce...

journal_title：International forum of allergy & rhinology

authors： Zhao Y,Zhang Y,Zhang L

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Early postoperative care following endoscopic sinus surgery (ESS) has been suggested to minimize avoidable complications and optimize long-term outcomes. Several postoperative care strategies have been proposed but a formal comprehensive evaluation of the evidence has never been performed. The purpose of thi...

journal_title：International forum of allergy & rhinology

authors： Rudmik L,Soler ZM,Orlandi RR,Stewart MG,Bhattacharyya N,Kennedy DW,Smith TL

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The lateral nasal wall (LNW) flap provides vascularized endonasal reconstruction primarily in revision surgery. Although the harvesting technique and reconstructive surface have been reported, the arterial supply to the LNW flap and its clinical implications is not well defined. This study presents anatomica...

journal_title：International forum of allergy & rhinology

authors： Lavigne P,Vega MB,Ahmed OH,Gardner PA,Snyderman CH,Wang EW

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is associated with sleep dysfunction, but the underlying pathophysiology is poorly understood. The purpose of this study was to determine if mucosal eosinophilia or neutrophilia were associated with sleep dysfunction severity or altered the improvement in sleep dysfunction follow...

journal_title：International forum of allergy & rhinology

authors： Farrell NF,Mace JC,Sauer DA,Thomas AJ,Geltzeiler M,Detwiller KY,Alt JA,Smith TL

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Techniques for inferior turbinate reduction vary from complete turbinectomy to limited cauterization. Surgical methods differ on the degree of tissue reduction and reliance on surgical tissue removal vs tissue ablation. The outcome and morbidity from 3 different turbinate techniques are compared. METHODS:A ...

journal_title：International forum of allergy & rhinology

authors： Barham HP,Thornton MA,Knisely A,Marcells GN,Harvey RJ,Sacks R

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Multiple prospective and retrospective studies have reported results from balloon-only procedures and hybrid balloon sinus surgeries through intermediate follow-up periods of up to 1 year. Long-term durability results beyond 2 years are limited. METHODS:One-year results from the original study of standalone...

journal_title：International forum of allergy & rhinology

authors： Stankiewicz J,Truitt T,Atkins J,Winegar B,Cink P,Raviv J,Henderson D,Tami T

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:After endoscopic sinus surgery (ESS), endoscopy is used to gauge surgical success and clinical outcomes. Prior studies have not examined this topic prospectively using validated outcome metrics across multiple institutions. METHODS:A multi-institutional, prospective study of patients with chronic rhinosinus...

journal_title：International forum of allergy & rhinology

authors： Schlosser RJ,Storck K,Smith TL,Mace JC,Rudmik L,Shahangian A,Soler ZM

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:In lower airway disease such as asthma, epithelial cells have been shown to be potent regulators of dendritic cell (DC) functions. However, it is unclear how human sinonasal epithelial cells (HSNECs) from patients with sinusitis regulate DC functions. Therefore, in these studies we investigated the ability o...

journal_title：International forum of allergy & rhinology

authors： Mulligan JK,Mulligan RM,Atkinson C,Schlosser RJ

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Sinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy with a propensity for distant metastasis. In this study we describe the incidence and determinants of survival among patients with SNACC between the years 2004 and 2012 using the National Cancer Database (NCDB). METHODS:This was a retrospective...

journal_title：International forum of allergy & rhinology

authors： Trope M,Triantafillou V,Kohanski MA,Kuan EC,Tong CCL,Patel NN,Maina IW,Carey RM,Workman AD,Palmer JN,Adappa ND,Newman JG,Brant JA

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Bronchial asthma is one of the most common chronic diseases in childhood, with a current prevalence of 6% to 9%, but a prevalence that is increasing at an alarming rate. Asthma is a complex genetic disorder with strong environmental influence. It imposes a growing burden on our society in terms of morbidity,...

journal_title：International forum of allergy & rhinology

authors： Toskala E,Kennedy DW

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:As part of this primer, this article is intended to introduce new and emerging therapies for treating asthma. METHODS:A PubMed search was performed for the years 2013 through 2015 for asthma review, asthma treatment, asthma therapy, and asthma new. Subset searches were additionally performed as suggested by...

journal_title：International forum of allergy & rhinology

authors： Calhoun KH

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Spontaneous cerebrospinal fluid (CSF) rhinorrhea has been associated with elevated intracranial pressure (ICP). As such, ICP reducing measures are commonly employed to optimize repair. Although postoperative acetazolamide use has been described, no data currently exists on the potential for preoperative use....

journal_title：International forum of allergy & rhinology

authors： Tilak AM,Koehn H,Mattos J,Payne SC

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Antibiotics are commonly used in the management of both acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis. With their common use, they have become the leading medication for litigation. It is crucial for the provider to be familiar with potential complications and the medico-legal ramifi...

journal_title：International forum of allergy & rhinology

authors： Poetker DM,Smith TL

更新日期：2015-02-01 00:00:00