Abstract:
:Methylenecyclcopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in various soapberry (Sapindaceae) fruits. These toxins have been linked to illnesses worldwide and were recently implicated in Asian outbreaks of acute hypoglycemic encephalopathy. In a previous joint agricultural and public health investigation, we developed an analytical method capable of evaluating MCPG and HGA concentrations in soapberry fruit arils as well as a clinical method for the urinary metabolites of the toxins. Since the initial soapberry method only analyzed the aril portion of the fruit, we present here the extension of the method to include the fruit seed matrix. This work is the first method to quantitate both MCPG and HGA concentrations in the seeds of soapberry fruit, including those collected during a public health investigation. Further, this is the first quantitation of HGA in litchi seeds as well as both toxins in mamoncillo and longan seeds.
journal_name
Food Chemjournal_title
Food chemistryauthors
Sanford AA,Isenberg SL,Carter MD,Mojica MA,Mathews TP,Harden LA,Takeoka GR,Thomas JD,Pirkle JL,Johnson RCdoi
10.1016/j.foodchem.2018.04.093subject
Has Abstractpub_date
2018-10-30 00:00:00pages
449-454eissn
0308-8146issn
1873-7072pii
S0308-8146(18)30734-9journal_volume
264pub_type
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