18F-FDG PET/CT and MRI of a Mediastinal Malignant Granular Cell Tumor With Associated Recurrent Pericarditis.

Abstract:

:We report a rare case of a mediastinal malignant granular cell tumor in a 41-year-old man presenting with dyspnea, retrosternal chest pain, and recurrent pericardial effusion under treatment with corticosteroids. Because of recurrent episodes, further investigations with chest MRI and F-FDG PET/CT revealed a large infiltrating and strongly hypermetabolic mass in the mediastinum with pericarditis. Histopathology and immunohistochemical analysis showed large cells with greater pleomorphism and eosinophilic granular cytoplasm with positive staining for S100 protein and CD68 as well as high Ki67 proliferative index (15%) confirming the diagnosis of a malignant granular cell tumor.

journal_name

Clin Nucl Med

authors

D'hulst L,Deroose C,Strybol D,Coolen J,Gheysens O

doi

10.1097/RLU.0000000000002137

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

589-590

issue

8

eissn

0363-9762

issn

1536-0229

journal_volume

43

pub_type

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