Abstract：
:Relative to adults, adolescents are at greater risk of developing a cannabis use disorder (CUD) and risk may be exacerbated by co-occurring depressive symptoms. N-Acetylcysteine (NAC), an over-the-counter antioxidant, is thought to normalize glutamate transmission. Oxidative stress and glutamate transmission are disrupted in both depression and CUD. Thus, NAC may be particularly effective at promoting cannabis abstinence among adolescents with elevated depressive symptoms. Secondary analyses were conducted using a sub-sample of adolescents with CUD (N = 74) who participated in an 8-week randomized placebo-controlled clinical trial examining the efficacy of NAC for cannabis cessation. It was hypothesized that NAC would reduce severity of depressive symptoms, and that decreases depressive symptom severity would mediate decreases in positive weekly urine cannabinoid tests (11-nor-9-carboxy-Δ9-tetrahydrocannabinol). Additionally, it was expected that adolescents with greater severity of baseline depressive symptoms would be more likely to become abstinent when assigned NAC relative to placebo. Results from linear mixed models and generalized estimating equations did not suggest that NAC reduced severity of depressive symptoms, and the hypothesis that NAC's effect on cannabis cessation would be mediated by reduced depressive symptoms was not supported. However, an interaction between treatment condition and baseline severity of depressive symptoms as a predictor of weekly urine cannabinoid tests was significant, suggesting that NAC was more effective at promoting abstinence among adolescents with heightened baseline depressive symptoms. These secondary findings, though preliminary, suggest a need for further examination of the role of depressive symptoms in treatment of adolescent CUD with NAC.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Tomko RL,Gilmore AK,Gray KMdoi
10.1016/j.addbeh.2018.05.014subject
Has Abstractpub_date
2018-10-01 00:00:00pages
26-30eissn
0306-4603issn
1873-6327pii
S0306-4603(18)30516-1journal_volume
85pub_type
杂志文章abstract：:A group of 35 alcoholics who indicated they had symptoms of phobia, panic, or both (the anxiety problem group) were compared to their matched controls who did not indicate having anxiety problems. Comparisons of relapse rates, reasons for relapse, and rates of emotional problems at six months posttreatment were made. ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(92)90048-z
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journal_title：Addictive behaviors
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journal_title：Addictive behaviors
pub_type： 杂志文章
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2004.10.006
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abstract：:Frequency and durational components of smoking topography were measured by a portable smoking device while 10 subjects smoked four cigarettes ad libitum in a non-laboratory environment. Nicotine blood levels were measured before and after smoking each cigarette and serial blood samples for determining nicotine metabol...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(88)90031-7
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abstract：INTRODUCTION:Craving has been proposed as a major contributor to addiction relapse and the influence of mood on craving and substance use has been extensively documented. However, information is lacking concerning the extent to which the magnitude of these effects may vary according to different types of substances. Th...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.01.041
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abstract：:The present study examined two behavioral processes - response perseveration and response adaptation - in adolescents who were heavy marijuana smokers and control adolescents. Testing took place in a controlled laboratory setting, using customized software and either a computer keyboard or a custom built response pane...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.07.007
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2013.03.017
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Adolescents with substance use (SU) problems have high rates of tobacco use, yet SU treatment has historically ignored treatment for tobacco use. Barriers to such efforts include the belief that tobacco cessation could compromise other SU abstinence. This study examines self-initiated tobacco cessation and 12-m...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2008.10.002
更新日期：2009-02-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.03.020
更新日期：2007-01-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.05.010
更新日期：2014-10-01 00:00:00
abstract：UNLABELLED:Prescription opioid misuse has been declared an American epidemic and a significant proportion of misused opioids are diverted from legitimate prescriptions. Patient education regarding appropriate use and the dangers of misuse has been identified as a key intervention target. The current study presents find...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2013.01.019
更新日期：2013-06-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2016.02.017
更新日期：2016-07-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(01)00184-8
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Many studies have reported that Anxiety Sensitivity (AS) is positively associated with alcohol use or other alcohol-related variables. More recent mediator and moderator models have shown promise in elucidating mechanisms within this relationship; the literature to date suggests that the relationship between...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.04.002
更新日期：2014-08-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.10.006
更新日期：2015-02-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章,多中心研究
doi：10.1016/j.addbeh.2008.12.003
更新日期：2009-05-01 00:00:00
abstract：:Despite considerable research activity and application in treatment, the construct of craving remains poorly understood. We propose that cravings and urges are cognitive-emotional events in time, characterised by frequency, duration, intensity and salience. Commonly used measures of alcohol craving are reviewed, and t...
journal_title：Addictive behaviors
pub_type： 杂志文章,评审
doi：10.1016/j.addbeh.2012.08.004
更新日期：2013-02-01 00:00:00
abstract：:Functional neuroimaging studies of cue-elicited craving in smokers have identified a distributed system of brain activation which includes the frontal cortex. As electroencephalographic (EEG) activity recorded from frontal brain regions indexes emotive functions, which are believed to play a key role in craving proces...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2007.11.006
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Prior research indicates that Latino immigrants are less likely than US-born individuals to use alcohol and meet criteria for an alcohol use disorder. However, our understanding of alcohol-related problem behaviors among Latino immigrants remains limited. We report the prevalence of alcohol-related problem b...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.06.031
更新日期：2018-12-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.10.032
更新日期：2019-07-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.09.030
更新日期：2019-02-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.12.002
更新日期：2007-08-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(99)00070-2
更新日期：2000-05-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2013.08.027
更新日期：2013-12-01 00:00:00
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journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.07.002
更新日期：2007-05-01 00:00:00
abstract：INTRODUCTION:Alcohol hangover experiences in young adulthood have been shown to predict more subsequent alcohol problems. Hangover susceptibility appears to be partially heritable and related to family history of alcohol use disorders. However, very little is known about the developmental course of these associations a...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.11.040
更新日期：2018-03-01 00:00:00
abstract：:Problematic Internet use (PIU) and problematic alcohol use are two pervasive problems during adolescence that share similar characteristics and predictors. The first objective of this study was to analyze the temporal and reciprocal relationships among the main components of PIU from the cognitive-behavioral model (pr...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2014.09.009
更新日期：2015-01-01 00:00:00
abstract：:While it has been established that many women quit smoking during pregnancy, little is known about postpartum maintenance of smoking cessation and relapse. A sample of 567 women were surveyed at about 6 months postpartum in order to (a) describe the patterns of smoking relapse; (b) assess the perceived importance of s...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(90)90020-x
更新日期：1990-01-01 00:00:00
abstract：:The goal of the present research was to test the value of evaluative conditioning (EC) to unobtrusively change alcohol-related attitudes and drinking behavior. In the EC paradigm, participants had to spot an irrelevant target picture in a series of trials in which many different stimuli were presented. In the experime...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2010.08.012
更新日期：2010-12-01 00:00:00
