Abstract:
:Strategic delivery of IRDye 700DX (photosensitizer) is a key for improving its effect in photodynamic therapy. In this study, we have synthesized IRDye 700DX-conjugated polymers containing multiple cyclic RGD peptides to deliver IRDye 700DX selectively to tumor cells and tumor-associated blood vessels overexpressing αvβ3 integrin. Our polymer has a backbone of hydrophilic poly(ethylene glycol)-poly(L-glutamic acid) block copolymer, and cyclic RGD peptides are conjugated to side chains of the poly(L-glutamic acid) while IRDye 700DX is conjugated to the terminal of poly(ethylene glycol). The polymers exhibited selective accumulation to the target sites in a subcutaneous solid tumor, and the accumulation was augmented with the increased number of cyclic RGD peptides. More importantly, the polymer containing 15 cyclic RGD peptides in one construct revealed preferential accumulation on the tumor-associated blood vessels without compromising penetration to deep portions of the tumor, thereby drastically inhibiting tumor growth upon photoirradiation, while the polymer containing 5 cyclic RGD peptides showed moderate antitumor activity despite efficient accumulation in the tumor with almost homogenous intratumoral distribution. These results suggest that controlling the intratumoral distribution of IRDye 700DX is critical for successful PDT, and our polymer containing multiple cyclic RGD peptides may be a promising carrier for this spatial control.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dou X,Nomoto T,Takemoto H,Matsui M,Tomoda K,Nishiyama Ndoi
10.1038/s41598-018-26593-0subject
Has Abstractpub_date
2018-05-25 00:00:00pages
8126issue
1issn
2045-2322pii
10.1038/s41598-018-26593-0journal_volume
8pub_type
杂志文章abstract::Herein, we propose an advanced energy-storage system: all-graphene-battery. It operates based on fast surface-reactions in both electrodes, thus delivering a remarkably high power density of 6,450 W kg(-1)(total electrode) while also retaining a high energy density of 225 Wh kg(-1)(total electrode), which is comparabl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05278
更新日期:2014-06-13 00:00:00
abstract::Stable isotopes in water (e.g., δ2H and δ18O) are important indicators of hydrological and ecological patterns and processes. Tap water can reflect integrated features of regional hydrological processes and human activities. China is a large country with significant meteorological and geographical variations. This rep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43653
更新日期:2017-03-02 00:00:00
abstract::Proteins are the primary effectors of cellular function, including cellular metabolism, structural dynamics, and information processing. However, quantitative characterization of proteins at the single-cell level is challenging due to the tiny amount of protein available. Here, we present Abseq, a method to detect and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44447
更新日期:2017-03-14 00:00:00
abstract::Misuse of antibiotics in the clinical and agricultural sectors has caused the emergence of multidrug-resistant (MDR) Klebsiella pneumoniae which contributes a threat to human health. In this study, we assessed the feasibility of lavender essential oil (LVO) as an antimicrobial agent in combinatory therapy with meropen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55601-0
更新日期:2020-01-21 00:00:00
abstract::MITF is a known gene underlying autosomal dominant hearing loss, Waardenburg syndrome (WS). Biallelic MITF mutations have been found associated with a rare hearing loss syndrome consisting eye abnormalities and albinism; and a more severe type of WS whose heterozygous parents were affected with classic WS in both case...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69633-4
更新日期:2020-07-29 00:00:00
abstract::Agriculture provides livelihood for 65% of Nepal's population contributing for 27% of its GDP. Smallholder farms constitute 60% of farming segment. Distress farming, with inadequate minimum support price, subsidies and inadequate revenue generation force 29% of the general population to be malnourished. Farming system...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67657-4
更新日期:2020-06-29 00:00:00
abstract::Utilization of computational approach in the study of social behaviour of animals is increasing and we attempted such an approach in our study of tree-dwelling bats. These bats live in highly dynamic fission-fusion societies that share multiple roosts in a common home range. The key behavioural component associated wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72999-0
更新日期:2020-10-08 00:00:00
abstract::Obstructive sleep apnea (OSA) is associated with increasing risk of recurrent stroke and mortality. Nasogastric tubes used by dysphagic stroke patients may interfere with nasal continuous positive airway pressure (CPAP) due to air leakage. This study was evaluated the effects and short-term tolerability of high-flow n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65335-z
更新日期:2020-05-22 00:00:00
abstract::Dengue virus (DENV) infects 400 million people worldwide annually. Infection of more than one serotype of DENV highly corresponds to dengue hemorrhagic fever and dengue shock syndrome, which are the leading causes of high mortality. Due to lack of effective vaccines and unavailable therapies against DENV, discovery of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45171
更新日期:2017-03-24 00:00:00
abstract::Upconversion nanoparticles (UCNPs) are utilized extensively for biomedical imaging, sensing, and therapeutic applications, yet the molecular weight of UCNPs has not previously been reported. Herein, we present a theory based upon the crystal structure of UCNPs to estimate the molecular weight of UCNPs: enabling insigh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19415-w
更新日期:2018-01-18 00:00:00
abstract::In this paper, we investigate the possibility of improving efficiency in non-radiative wireless power transfer (WPT) using metasurfaces embedded between two current varying coils and present a complete theoretical analysis of this system. We use a point-dipole approximation to calculate the fields of the coils. Based ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-33174-8
更新日期:2018-10-05 00:00:00
abstract::Stimulation with lipopolysaccharide (LPS; endotoxin) not only causes rapid production of proinflammatory cytokines, but also induces a state of LPS hypo-responsiveness to a second LPS stimulation (endotoxin tolerance (ET)). Murine bone marrow-derived MCs (BMMCs) and peritoneal MCs (PMCs) developed ET as shown by an ab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04890-4
更新日期:2017-07-03 00:00:00
abstract::Nowadays, various collaborations are creating immense machines to try to track and understand the origin of high-energy cosmic particles (e.g., IceCube, ANTARES, Baikal-GVD, P-ONE). The detection mechanism of these sophisticated experiments relies mainly on an optical signal generated by the passage of charged particl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68954-8
更新日期:2020-07-24 00:00:00
abstract::Ga-68 Prostate-Specific Membrane Antigen PET/CT is a new tool for the assessment of prostate cancer. Standard imaging time is 60 minutes post injection of radiotracer. At 60 minutes, there is physiologic accumulation of radiotracer in the urinary bladder which may cause some lesions in its vicinity to be obscured. Our...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59296-6
更新日期:2020-02-17 00:00:00
abstract::CD134 (OX40) is a member of the tumour necrosis factor receptor superfamily (TNFRSF). It acts as a costimulatory receptor on T cells, but its role on NK cells is poorly understood. CD137, another TNFRSF member has been shown to enhance the anti-tumour activity of NK cells in various malignancies. Here, we examine the ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20656-y
更新日期:2018-02-02 00:00:00
abstract::Orexins are originally characterized as orexigenic hypothalamic neuropeptides in mammals. Subsequent studies found orexin to be expressed and perform pleiotropic functions in multiple tissues in mammals. In avian (non-mammalian) species, however, orexin seemed to not affect feeding behavior and its physiological roles...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76329-2
更新日期:2020-11-05 00:00:00
abstract::Since the production of ferromagnetic graphene as an extremely important matter in spintronics has made a revolution in future technology, a great deal of efforts has recently been done to reach a simple and cost-effective method. Up to now, controlling the magnetic properties at extremely low temperature have been in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78262-w
更新日期:2020-12-07 00:00:00
abstract::Forest cutting is a major anthropogenic disturbance that affects forest carbon (C) storage and fluxes. Yet its characteristics and impacts on C cycling are poorly understood over large areas. Using recent annualized forest inventory data, we estimated cutting-related loss of live biomass in the eastern United States w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03547
更新日期:2013-12-19 00:00:00
abstract::Neuroinflammation and accompanying microglial dysfunction are now appreciated to be involved in Alzheimer's disease (AD) pathogenesis. Critical to the process of neuroinflammation are the type-I interferon (IFN) family of cytokines. Efforts to phenotypically characterize microglia within AD identify distinct populatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59917-0
更新日期:2020-02-21 00:00:00
abstract::Spirometry is required to confirm a chronic obstructive pulmonary disease (COPD) diagnosis, but it is difficult to perform in resource-limited settings. This study aimed to evaluate symptom-based questions for screening of individuals with COPD among Chinese populations. We recruited 3969 adult subjects from the First...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30419
更新日期:2016-07-26 00:00:00
abstract::We experimentally perform the simulation of open quantum dynamics in single-qudit systems. Using a spatial light modulator as a dissipative optical device, we implement dissipative-dynamical maps onto qudits encoded in the transverse momentum of spontaneous parametric down-converted photon pairs. We show a well-contro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16049
更新日期:2015-11-03 00:00:00
abstract::Twenty-six imprinted genes were quantified in bovine in vivo produced oocytes and embryos using RNA-seq. Eighteen were detectable and their transcriptional patterns were: largely decreased (MEST and PLAGL1); first decreased and then increased (CDKN1C and IGF2R); peaked at a specific stage (PHLDA2, SGCE, PEG10, PEG3, G...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17898
更新日期:2015-12-07 00:00:00
abstract::Carbon is the most well-known black material in the history of man. Throughout the centuries, carbon has been used as a black material for paintings, camouflage, and optics. Although, the techniques to make other black surfaces have evolved and become more sophisticated with time, carbon still remains one of the best ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25922
更新日期:2016-05-13 00:00:00
abstract::Mammals typically keep their body temperature (Tb) within a narrow limit with changing environmental conditions. There are indications that some wild ungulates can exhibit certain forms of energy saving mechanisms when ambient temperatures are low and/or food is scarce. Therefore, the aim of the study was to determine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-07946-7
更新日期:2017-08-08 00:00:00
abstract::Traditional risk assessment and source apportionment of sediments based on bulk polycyclic aromatic hydrocarbons (PAHs) can introduce biases due to unknown aging effects in various sediments. We used a mild solvent (hydroxypropyl-β-cyclodextrin) to extract the bioavailable fraction of PAHs (a-PAHs) from sediment sampl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23134
更新日期:2016-03-15 00:00:00
abstract::The design of active and stable semiconducting composites with enhanced photoresponse from visible light to near infrared (NIR) is a key to improve solar energy harvesting for photolysis of water in photoelectrochemical cell. In this study, we prepared earth abundant semiconducting composites consisting of iron pyrite...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20397
更新日期:2016-02-08 00:00:00
abstract::Some studies have reported that upper limb tightness is a risk factor for shoulder/elbow pain in high school baseball pitchers; but there has been insufficient research on the relationship between lower limb tightness and shoulder and elbow pain in pitchers. This study aimed to clarify the correlation among pre-season...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76894-6
更新日期:2020-11-17 00:00:00
abstract::Drying and aging paint dispersions display a wealth of complex phenomena that make their study fascinating yet challenging. To meet the growing demand for sustainable, high-quality paints, it is essential to unravel the microscopic mechanisms underlying these phenomena. Visualising the governing dynamics is, however, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34383
更新日期:2016-09-29 00:00:00
abstract::Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42932-1
更新日期:2019-04-23 00:00:00
abstract::RNA is transcribed from DNA, and therefore, there should be no RNA transcript from the deleted DNA region. Our study attempted to analyse whether any RNA cache that maps the deleted regions is present in human cells. Using data from the 1000 genome project, we selected 41 CEPH (CEU) and 38 Yoruba (YRI) samples that in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37452
更新日期:2016-11-17 00:00:00