Abstract:
:Classical simulations of protein flexibility remain computationally expensive, especially for large proteins. A few years ago, we developed a fast method for predicting protein structure fluctuations that uses a single protein model as the input. The method has been made available as the CABS-flex web server and applied in numerous studies of protein structure-function relationships. Here, we present a major update of the CABS-flex web server to version 2.0. The new features include: extension of the method to significantly larger and multimeric proteins, customizable distance restraints and simulation parameters, contact maps and a new, enhanced web server interface. CABS-flex 2.0 is freely available at http://biocomp.chem.uw.edu.pl/CABSflex2.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Kuriata A,Gierut AM,Oleniecki T,Ciemny MP,Kolinski A,Kurcinski M,Kmiecik Sdoi
10.1093/nar/gky356subject
Has Abstractpub_date
2018-07-02 00:00:00pages
W338-W343issue
W1eissn
0305-1048issn
1362-4962pii
4995689journal_volume
46pub_type
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