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Hypoglycemic activity in vitro of polysaccharides from Camellia oleifera Abel. seed cake.

Abstract：

:We isolated and purified polysaccharide from the Camellia oleifera Abel. seed cake (CCP) and studied its hypoglycemic activity in vitro. The molecular weight of CCP was 4736 Da and the monosaccharide molar composition ratio was: Xylose:Glucuronic acid:Galactosamine:Mannose = 10.9:4.4:2.6:1.8. The CCP contained conjugated proteins and belonged to acidic polysaccharide, which can promote the consumption of the glucose in the medium by HepG2 cells within the range of 0.125-0.500 mg/mL. Relative consumption rate (RCR) of the glucose was the highest at 0.5 mg/mL, exceeded that of the metformin hydrochloride, as well as that of Tea Polysaccharide under the same concentration. A meaningful structure activity relationship (SAR) of hypoglycemia polysaccharides had established. This result suggests that CCP can be used as hypoglycemic medicine or health food.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zhang S,Li X

doi

10.1016/j.ijbiomac.2018.04.054

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

811-819

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)33860-6

journal_volume

115

pub_type

杂志文章

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