Abstract:
:The physical strength of the collagen fibre network in the extracellular matrix is due to the covalent crosslinks between the molecules within the fibres (intra-fibrillar crosslinks). Citric acid was investigated as an agent to introduce crosslinks within marine collagen electrospun fibres. We used collagen films to understand the ideal conditions for citric acid crosslinking. This information was used to develop an optimised method for intra-fibrillar crosslinking in electrospun marine collagen fibres, which increased the stability of these fibres in aqueous environments. The optimised method included a spinning solution containing collagen and citric acid at pH3.5 at high concentrations (260:1 citric acid:collagen molar ratio) coupled with high temperature annealing (165°C), which resulted in the highest intra-fibrillar crosslinking density in electrospun fibres.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Cumming MH,Leonard AR,LeCorre-Bordes DS,Hofman Kdoi
10.1016/j.ijbiomac.2018.03.180subject
Has Abstractpub_date
2018-07-15 00:00:00pages
874-881eissn
0141-8130issn
1879-0003pii
S0141-8130(18)30501-4journal_volume
114pub_type
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