lncRNAPCAT29 inhibits pulmonary fibrosis via the TGF‑β1‑regulated RASAL1/ERK1/2 signal pathway.

abstract：:Circular RNAs (circRNAs) are non-coding RNAs forming closed-loop structures, and their aberrant expression may lead to disease. However, the potential network of circRNA‑associated competing endogenous RNA (ceRNA) involved in nonvalvular persistent atrial fibrillation (NPAF) has not been previously reported. In the pr...

journal_title：Molecular medicine reports

authors： Zhang Y,Ke X,Liu J,Ma X,Liu Y,Liang D,Wang L,Guo C,Luo Y

更新日期：2019-01-01 00:00:00

abstract：:The present study aimed to reveal the potential genes associated with the pathogenesis of intervertebral disc degeneration (IDD) by analyzing microarray data using bioinformatics. Gene expression profiles of two regions of the intervertebral disc were compared between patients with IDD and controls. GSE70362 containin...

journal_title：Molecular medicine reports

authors： Guo W,Zhang B,Li Y,Duan HQ,Sun C,Xu YQ,Feng SQ

更新日期：2017-12-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis-inducing ligand (TRAIL) is well known as a transmembrane cytokine and has been proposed as one of the most effective anti‑cancer therapeutic agents, owing to its efficiency to selectively induce cell death in a variety of tumor cells. Suppression of autophagy flux has been incre...

journal_title：Molecular medicine reports

authors： Nazim UM,Yin H,Park SY

更新日期：2019-02-01 00:00:00

abstract：:Human forkhead box P3 (FOXP3)+ cluster of differentiation (CD)25+CD4+ regulatory T cells (Tregs) are a type of T cell that express CD4, CD25 and FOXP3, which are critical for maintaining immune homeostasis. The present study aimed to determine the mechanisms underlying Treg function. The GSE11292 dataset was downloade...

journal_title：Molecular medicine reports

authors： Bai X,Shi H,Yang M,Wang Y,Sun Z,Xu S

更新日期：2018-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are non‑coding RNAs of ~22 nucleotides in length, which serve an important role in numerous diseases. Asthma is a chronic airway inflammatory disease, which is the most common chronic disease among children. The role of miRNA (miR)‑16 in asthma is unclear. The objective of the present study was to e...

journal_title：Molecular medicine reports

authors： Yu B,Yao L,Liu C,Tang L,Xing T

更新日期：2019-05-01 00:00:00

abstract：:Retroviral vectors have been considered the most promising vehicles for the transfer of therapeutic genes into cells of the hematopoietic system. In clinical studies, however, cases of leukemoid clonogenic expansion of the transduced cells in vivo caused by semirandom integration of the foreign DNA in the genome have ...

journal_title：Molecular medicine reports

authors： Zehnpfennig D,Deissler H,Polack A,Herr D,Bornkamm GW,Kurzeder C

更新日期：2010-07-01 00:00:00

abstract：:Metabolic syndrome based on insulin resistance (IR) and hypertension is a risk factor for advanced liver disease and cardiovascular disease in patients with nonalcoholic steatohepatitis (NASH). The present study investigated the effects of severe hypertension induced by a high‑salt (HS) diet and antihypertensive thera...

journal_title：Molecular medicine reports

authors： Kozono M,Uto H,Ibusuki R,Arima S,Oda K,Taguchi H,Sasaki F,Nasu Y,Hashimoto S,Setoyama H,Kanmura S,Numata M,Tsubouchi H,Ido A

更新日期：2016-12-01 00:00:00

abstract：:The activation of the (pro)renin receptor (PRR) may be potentially active in the development of atherosclerotic plaques independent of angiotensin II. Our previous studies demonstrated that high glucose was able to induce the activation of PRR. The present study was designed to determine the function of oxidized low‑d...

journal_title：Molecular medicine reports

authors： Cheng Y,Liu X,Zhang L,Zhang Y,Liu Y,Lu Y,Jiang Y

更新日期：2015-06-01 00:00:00

abstract：:Cardiovascular diseases have become one of the major public health problems in many countries. The downregulation of MYBL2 was found in H9c2 and native cardiomyocytes cells after hypoxia treatment. The present study aimed to investigate the effects of MYB proto‑oncogene like 2 (MYBL2) on H9c2 injury induced by hypoxia...

journal_title：Molecular medicine reports

authors： Shao M,Ren Z,Zhang R

更新日期：2018-03-01 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to be important in the establishment and progression of colon cancer. However the underlying molecular mechanisms remain to be fully elucidated. Polypeptide N‑acetylgalactosaminyltransferase4 (GALNT4) participates in numerous cellular processes, including tumorigenesis. The pres...

journal_title：Molecular medicine reports

authors： Qu JJ,Qu XY,Zhou DZ

更新日期：2017-10-01 00:00:00

abstract：:Microglia‑mediated neuroinflammation is key in the pathogenesis of Alzheimer's disease (AD). Several studies have suggested that NADPH oxidase contributes to microglia‑mediated neuroinflammation. Resveratrol, which is a natural polyphenolic compound, exerts neuroprotective effects in AD due to its anti‑inflammatory pr...

journal_title：Molecular medicine reports

authors： Yao Y,Li J,Niu Y,Yu JQ,Yan L,Miao ZH,Zhao XX,Li YJ,Yao WX,Zheng P,Li WQ

更新日期：2015-10-01 00:00:00

abstract：:Tuberous sclerosis (TS) is caused by mutation of the tumor suppressor genes, tuberous sclerosis complex 1 (TSC1) or 2 (TSC2). The aim of the present study was to compare the frequency and types of TSC1 and TSC2 mutations in American, British, Polish and Taiwanese populations. A meta‑analysis of 380 TS patients was per...

journal_title：Molecular medicine reports

authors： Jóźwiak J,Sontowska I,Płoski R

更新日期：2013-09-01 00:00:00

abstract：:Thyroid stimulating hormone (TSH) consists of an α‑subunit and a unique β‑subunit. The first in‑frame TSHβ splice variant produced by the cells of immune system was identified in 2009. The TSHβ splice variant and native TSHβ exhibit different expression profiles, and research has been conducted to elucidate the role o...

journal_title：Molecular medicine reports

authors： Liu C,Miao J,Liu X,Zhao Z,Kou T,Liu J,Wang R,Li L,Dong Q

更新日期：2019-05-01 00:00:00

abstract：:Identification of novel risk factors that are critical to the initiation of lung cancer will be key for its prevention. Recently, it has been reported that glycine dehydrogenase (GLDC) can drive the formation of lung cancer initiating cells. However, there have been no perspective studies on the association between ci...

journal_title：Molecular medicine reports

authors： Wei HY,Feng R,Shao H,Feng B,Liu HQ,Men JL,Zou W

更新日期：2018-08-01 00:00:00

abstract：:The expression of Ferroportin (Fpn) was examined at different time points in rats following focal cerebral ischemia treated with or without the traditional Chinese medicine Naotaifang. Initially, rats were randomly divided into 2, 6, 12, 24 and 72 h groups following middle cerebral artery occlusion (MCAO) and the mRNA...

journal_title：Molecular medicine reports

authors： Liao J,Xia X,Wang GZ,Shi YM,Ge JW

更新日期：2015-06-01 00:00:00

abstract：:Dysregulation of microRNAs (miRNAs) is associated with the occurrence and development of clear cell renal cell carcinoma (ccRCC) through their participation in a number of critical biological processes. Therefore, an in‑depth investigation into miRNAs and their biological roles within ccRCC may provide useful insights...

journal_title：Molecular medicine reports

authors： Zhao H,Zhao H,Xia X,Liu X

更新日期：2018-05-01 00:00:00

abstract：:Atrial fibrillation (AF) is one of the most common types of arrhythmia worldwide; although a number of theories have been proposed to explain the mechanisms of AF, the treatment of AF is far from satisfactory. Energy metabolism is associated with the development of AF. Mitochondrial transcription factor A (TFAM) serve...

journal_title：Molecular medicine reports

authors： Liu Y,Zhao Y,Tang R,Jiang X,Wang Y,Gu T

更新日期：2020-12-01 00:00:00

abstract：:Cardiac fibrosis is one of the pathological characteristics of diabetic cardiomyopathy (DbCM). Matrine treatment has proven to be effective in cases of organ fibrosis and cardiovascular diseases. In the present study, the anti-fibrosis-associated cardioprotective effects of matrine on DbCM were investigated. Rats with...

journal_title：Molecular medicine reports

authors： Zhang Y,Cui L,Guan G,Wang J,Qiu C,Yang T,Guo Y,Liu Z

更新日期：2018-01-01 00:00:00

abstract：:Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs. However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) plays a crucial role in regulating immunity and inflammation. It has been reported that pyrrolidine dithiocarbamate (PDTC), an inhibi...

journal_title：Molecular medicine reports

authors： He X,Song Y,Wang L,Xu J

更新日期：2020-01-01 00:00:00

abstract：:NOVA alternative splicing regulator 1 (NOVA1) dysregulation has been detected in the gastric cancer microenvironment. Decreased NOVA1 expression has been linked to the progression and poor prognosis of gastric cancer; however, the role of NOVA1 in regulating epithelial‑mesenchymal transition (EMT) remains unclear in t...

journal_title：Molecular medicine reports

authors： Li K,Zhu X,Chen X,Wang X

更新日期：2020-03-01 00:00:00

abstract：:Long non‑coding RNAs (lncRNAs) play critical roles in the development and progression of cancers. The present study aimed to identify novel lncRNAs and associated microRNAs (miRNAs or miRs) and mRNAs in gastric cancer. Differentially expressed lncRNAs (DElncRNAs) and differentially expressed mRNAs (DEmRNAs) of 6 paire...

journal_title：Molecular medicine reports

authors： Gu W,Ren JH,Zheng X,Hu XY,Hu MJ

更新日期：2019-09-01 00:00:00

abstract：:The results of surgical repair of extensive muscle tissue defects are still of primary concern, leaving patients with residual cosmetic and functional impairments. Therefore, skeletal muscle tissue engineering attempts to grow functional neo‑tissue from human stem cells to promote tissue regeneration and support defec...

journal_title：Molecular medicine reports

authors： Mueller CE,Birk R,Kramer B,Wenzel A,Sommer JU,Hörmann K,Stern-Straeter J,Weilbach C

更新日期：2018-03-01 00:00:00

abstract：:In contrast with mature brain‑derived neurotrophic factor (mBDNF), proBDNF induces cell apoptosis. However, the function of proBDNF in oligodendrocytes remains unclear. In the present study, the OLN‑93 oligodendroglia cell line was utilized as an in vitro model to analyse the functions of proBDNF in oligodendroglia. p...

journal_title：Molecular medicine reports

authors： Liu S,Guo W,Zhou H,Tang L,Feng S,Zhong JH,Zhou XF

更新日期：2018-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) are critical in the induction of the immune response in tumor development. TLR7 has previously been demonstrated to be associated with the development of pancreatic cancer, and the release of cytokines and chemokines from other types of cancer cell; however, the specific expression induced b...

journal_title：Molecular medicine reports

authors： Wang F,Jin R,Zou BB,Li L,Cheng FW,Luo X,Geng X,Zhang SQ

更新日期：2016-02-01 00:00:00

abstract：:A type of aplastic anemia (AA), non-severe aplastic anemia (NSAA) is defined as AA that does not meet the diagnostic criteria of severe aplastic anemia (SAA). Complement component 1q (C1q) has an important role in the pathogenesis of various autoimmune diseases; however, the role of C1q in the immune pathogenesis of N...

journal_title：Molecular medicine reports

authors： Ding S,Liu C,Li Y,Liu H,Liu Z,Chen T,Zhang T,Shao Z,Fu R

更新日期：2019-02-01 00:00:00

abstract：:The generation of β‑amyloid protein (Aβ) is considered a key step in the pathogenesis of Alzheimer's disease (AD) and the regulation of its production is an important therapeutic strategy. It was hypothesized in the present study that Nogo‑A may be involved in AD and may regulate the generation of Aβ. Nogo‑A is known ...

journal_title：Molecular medicine reports

authors： Xie QQ,Feng X,Huang YΥ,Fang N,Yi H,Wang ZJ,Cao QΥ,Lou GF,Pan JP,Hu Y,Li FC,Zheng Q,Xiao F

更新日期：2021-03-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a rare but devastating malignancy. Up to 90% of patients presenting with CCA have no identifiable risk factors. The base excision repair (BER) pathway has a principal role in the repair of mutations caused by oxidized or reduced bases. The MutY homolog (MUTYH, MYH) is one of the key protein...

journal_title：Molecular medicine reports

authors： You SH,Wang X,Huang S,Wang M,Ji GZ,Xia JR,Fan ZN

更新日期：2013-01-01 00:00:00

abstract：:Our previous study demonstrated that human umbilical cord mesenchymal stem cells (HUMSCs) were capable of differentiation into germ cells in vitro. To assess this potential in vivo, HUMSCs were microinjected into the lumen of seminiferous tubules of immunocompetent mice, which were treated with busulfan to destroy end...

journal_title：Molecular medicine reports

authors： Chen H,Tang QL,Wu XY,Xie LC,Lin LM,Ho GY,Ma L

更新日期：2015-07-01 00:00:00

abstract：:We investigated the effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-β1 protein expression in rat endplate chondrocytes in vitro. Endplate chondrocytes were isolated and cultured in vitro. Following identific...

journal_title：Molecular medicine reports

authors： Xu HG,Hu CJ,Wang H,Liu P,Yang XM,Zhang Y,Wang LT

更新日期：2011-09-01 00:00:00

abstract：:Stem cells from apical papilla (SCAP) possess clear osteo‑/odontogenic differentiation capabilities, and are regarded as the major cellular source for root dentin development. Bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor (VEGF) serve pivotal roles in the modulation of tooth development an...

journal_title：Molecular medicine reports

authors： Zhang W,Zhang X,Ling J,Wei X,Jian Y

更新日期：2016-05-01 00:00:00