Abstract:
Background:The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra, shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola family, Rhodiola crenulata, has previously been shown to confer positive effects on the gut homeostasis of the fruit fly, Drosophila melanogaster. Although, R. rosea has been shown to extend lifespan of many organisms such as fruit flies, worms and yeast, its anti-aging mechanism remains uncertain. Using D. melanogaster as our model system, the purpose of this work was to examine whether the anti-aging properties of R. rosea are due to its impact on the microbial composition of the fly gut. Results:Rhodiola rosea treatment significantly increased the abundance of Acetobacter, while subsequently decreasing the abundance of Lactobacillales of the fly gut at 10 and 40 days of age. Additionally, supplementation of the extract decreased the total culturable bacterial load of the fly gut, while increasing the overall quantifiable bacterial load. The extract did not display any antimicrobial activity when disk diffusion tests were performed on bacteria belonging to Microbacterium, Bacillus, and Lactococcus. Conclusions:Under standard and conventional rearing conditions, supplementation of R. rosea significantly alters the microbial community of the fly gut, but without any general antibacterial activity. Further studies should investigate whether R. rosea impacts the gut immunity across multiple animal models and ages.
journal_name
Gut Pathogjournal_title
Gut pathogensauthors
Labachyan KE,Kiani D,Sevrioukov EA,Schriner SE,Jafari Mdoi
10.1186/s13099-018-0239-8subject
Has Abstractpub_date
2018-03-20 00:00:00pages
12issn
1757-4749pii
239journal_volume
10pub_type
杂志文章相关文献
Gut Pathogens文献大全abstract:BACKGROUND:The development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. The belief that AGP modulate the intestinal microbiota has become prominent in the literature; however, t...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-3-14
更新日期:2011-09-25 00:00:00
abstract:Background:The human gut microbiome has an important role in health and disease. There is extensive geographical variation in the composition of the gut microbiome, however, little is known about the gut microbiome composition of people from the Arabian Peninsula. In this study, we describe the gut microbiome of Arab K...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-020-00351-y
更新日期:2020-02-26 00:00:00
abstract::Potential biological roles of the Campylobacter jejuni genes cj0641, cj0774c and cj1663 were investigated. The proteins encoded by these genes showed sequence similarities to the phosphonate utilisation PhnH, K and L gene products of Escherichia coli. The genes cj0641, cj0774c and cj1663 were amplified from the pathog...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-13
更新日期:2009-06-25 00:00:00
abstract:BACKGROUND:Klebsiella pneumoniae is the most common pathogen of community-acquired pyogenic liver abscess in East Asia. Diabetes mellitus (DM) is a well-established risk factor for K. pneumoniae liver abscess (KPLA). However, reports regarding the emergence of KPLA in non-diabetic patients are limited. RESULTS:A total...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-016-0128-y
更新日期:2016-10-18 00:00:00
abstract::[This corrects the article DOI: 10.1186/1757-4749-6-28.]. ...
journal_title:Gut pathogens
pub_type: 已发布勘误
doi:10.1186/s13099-016-0120-6
更新日期:2016-08-10 00:00:00
abstract:Background:Shigella has evolved as a result of acquiring extragenetic material through horizontal gene exchange. These aid in the rapid emergence of bacterial inter-strain diversity in virulence factors and serotype variants through O-antigenic switching. Plasmid incompatibility typing of isolates is insightful in unde...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-019-0314-9
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:Acid treatment is commonly used for controlling or killing pathogenic microorganisms on medical devices and environments; however, inadequate acid treatment may cause acid tolerance response (ATR) and offer cross-protection against environmental stresses, including antimicrobials. This study aimed to charact...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-020-00390-5
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Shigella is a frequent cause of bacterial dysentery in the developing world. Treatment with effective antibiotics is recommended for shigellosis, but options become limited due to globally emerging resistance. One of the mechanisms for the development of resistance utilizes integrons. This study described th...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-2-18
更新日期:2010-12-09 00:00:00
abstract:BACKGROUND:Clostridium difficile is an anaerobic Gram-positive spore-forming gut pathogen that causes antibiotic-associated diarrhea worldwide. A small number of C. difficile strains express the binary toxin (CDT), which is generally found in C. difficile 027 (ST1) and/or 078 (ST11) in clinic. However, we isolated a bi...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0191-z
更新日期:2017-08-07 00:00:00
abstract:Introduction:Quinolone prophylaxis is recommended for patients with advanced cirrhosis at high risk of spontaneous bacterial peritonitis (SBP) or with prior SBP. Yet, the impact of long-term antibiotic prophylaxis on the microbiome of these patients is poorly characterized. Methods:Patients with liver cirrhosis receiv...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-020-00389-y
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:The putative H. pylori pathogenicity-associated factor dupA has been associated with IL-8 induction in vitro, and duodenal ulcer (DU) and gastric cancer (GC) development in certain populations, but this association is inconsistent between studies. We aimed to investigate dupA prevalence in clinical isolates ...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-5
更新日期:2009-03-11 00:00:00
abstract:BACKGROUND:Salmonella enterica serovar Typhi (S. Typhi) exhibits unique characteristics as an intracellular human pathogen. It causes both acute and chronic infection with various disease manifestations in the human host only. The principal factors underlying the unique lifestyle of motility and biofilm forming ability...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-6-2
更新日期:2014-02-05 00:00:00
abstract:BACKGROUND:How host cell glycosylation affects EPEC or EHEC O157:H7 invasion is unclear. This study investigated whether and how O-glycans were involved in EPEC or EHEC O157:H7 invasion into HT-29 cells. RESULTS:Lectin histochemical staining confirmed stronger staining with PNA, which labeled Galβ1, 3 GalNAc (core 1 s...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-015-0078-9
更新日期:2015-12-15 00:00:00
abstract:BACKGROUND:Shigellosis is an acute form of gastroenteritis caused by the bacteria belonging to the genus Shigella. It is the most common cause of morbidity and mortality in children. Shigella belongs to the family Enterobactericeae, which is a Gram-negative and rod shaped bacterium. In the present study, we report the ...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-6-28
更新日期:2014-07-11 00:00:00
abstract::In the present study we demonstrate that the initial attachment of Listeria monocytogenes cells to plastic surfaces was significantly increased by growth in the presence of bile. Improved biofilm formation was confirmed by crystal violet staining, microscopy and bioluminescence detection of a luciferase-tagged strain....
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-11
更新日期:2009-05-28 00:00:00
abstract::As the associations between the gut microbiota and numerous health outcomes become more evident, it is important to conduct longitudinal microbiome research to advance the field beyond the identification of associations. It is also necessary to include individuals who have historically been underrepresented in biomedi...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-019-0324-7
更新日期:2019-08-26 00:00:00
abstract:BACKGROUND:Helicobacter pylori infection is associated with risk for chronic gastritis (CG), gastric ulcer (GU), duodenal ulcer (DU), and gastric cancer (GC). The H. pylori Cag type IV secretion system (TFSS) translocates the virulence factor cytotoxin-associated gene A protein into host cells and plays an important ro...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0165-1
更新日期:2017-04-21 00:00:00
abstract:BACKGROUND:One of the working mechanisms of probiotic bacteria is their ability to compete with pathogens. To define the probiotic properties of seven Lactic Acid Bacteria (LAB) strains, we tested them for survival in simulated gastro-intestinal conditions, antimicrobial activities, co-aggregative abilities, and interf...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0162-4
更新日期:2017-03-06 00:00:00
abstract::The World Health Organisation, in its 2019 progress report on HIV, viral hepatitis and STDs indicates that 257 million people are afflicted with chronic HBV infections, of which, 1 million patients lose their lives every year due to HBV related chronic liver diseases including serious complications such as liver cirrh...
journal_title:Gut pathogens
pub_type: 杂志文章,评审
doi:10.1186/s13099-020-00353-w
更新日期:2020-04-24 00:00:00
abstract:BACKGROUND:Ruminants, in particular bovines, are the primary reservoir of Shiga toxin-producing E. coli (STEC), but whole genome analyses of the current German ESBL-producing O104:H4 outbreak strain of sequence type (ST) 678 showed this strain to be highly similar to enteroaggregative E. coli (EAEC). Strains of the EAE...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-3-17
更新日期:2011-11-03 00:00:00
abstract:BACKGROUND:Toll-like receptors (TLRs) are the major pattern recognition receptors that mediate sensing of a wide range of microorganisms. TLR2 forms heterodimers with either TLR1 or TLR6, broadening its ligand diversity against pathogens. TLR1, TLR2 and TLR6 have been implicated in the recognition of Candida albicans, ...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0158-0
更新日期:2017-02-15 00:00:00
abstract:UNLABELLED: BACKGROUND:Helicobacter pylori are successful colonizers of the human gastric mucosa. Colonization increases the risk of peptic ulcer disease and adenocarcinoma. However, potential benefits of H. pylori colonization include protection against early-onset asthma and against gastrointestinal infections. Camp...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-4-9
更新日期:2012-08-24 00:00:00
abstract:BACKGROUND:Physiological stressors may alter susceptibility of the host intestinal epithelium to infection by enteric pathogens. In the current study, cytotoxic effect, adhesion and invasion of Salmonella enterica serovar Typhimurium (S. Typhimurium) to Caco-2 cells exposed to thermal stress (41 degrees C, 1 h) was inv...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-14
更新日期:2009-07-09 00:00:00
abstract:BACKGROUND:Shiga toxin (Stx) producing Escherichia coli (E. coli) (STEC) is the most frequent cause of diarrhoea-positive haemolytic uraemic syndrome (D + HUS) in humans. In 2011, a huge outbreak with an STEC O104:H4 strain in Germany highlighted the limited possibilities for causative treatment of this syndrome. The r...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0179-8
更新日期:2017-05-25 00:00:00
abstract::The ability to adhere to host surfaces is by far the most vital step in the successful colonization by microbial pathogens. Colonization begins with the attachment of the bacterium to receptors expressed by cells forming the lining of the mucosa. Long hair like extracellular appendages called fimbriae, produced by mos...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-22
更新日期:2009-12-10 00:00:00
abstract:BACKGROUND:Coeliac disease is an autoimmune disorder resulting from an interaction between diet, genome and immunity. The treatment of CoeD is lifelong adherence to a gluten free diet, which is associated with clinical and histological improvements. However, a substantive number of individuals report only partial sympt...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/s13099-017-0173-1
更新日期:2017-05-05 00:00:00
abstract:BACKGROUND:Cronobacter sakazakii is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of severe diseases: meningitis, necrotizing enterocolitis, and sepsis in premature and full-term infants. However, the pathogenesis mechanism of this pathogen remains largely unknown. To determ...
journal_title:Gut pathogens
pub_type:
doi:10.1186/s13099-016-0150-0
更新日期:2017-01-04 00:00:00
abstract:BACKGROUND:Widely considered probiotic organisms, Bifidobacteria are common inhabitants of the alimentary tract of animals including insects. Bifidobacteria identified from the honey bee are found in larval guts and throughout the alimentary tract, but attain their greatest abundance in the adult hind gut. To further u...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-5-42
更新日期:2013-12-18 00:00:00
abstract::The two-stage neuroinflammatory process, containment and progression, proposed to underlie neurodegeneration may predicate on systemic inflammation arising from the gastrointestinal tract. Helicobacter infection has been described as one switch in the pathogenic-circuitry of idiopathic parkinsonism (IP): eradication m...
journal_title:Gut pathogens
pub_type: 杂志文章
doi:10.1186/1757-4749-1-20
更新日期:2009-11-26 00:00:00
abstract:BACKGROUND:Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children. RESULTS:Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs f...
journal_title:Gut pathogens
pub_type:
doi:10.1186/s13099-016-0135-z
更新日期:2016-11-08 00:00:00