Abstract:
:Motility of cilia (also known as flagella in some eukaryotes) is based on axonemal doublet microtubule sliding that is driven by the dynein molecular motors. Dyneins are organized into intricately patterned inner and outer rows of arms, whose collective activity is to produce inter-microtubule movement. However, to generate a ciliary bend, not all dyneins can be active simultaneously. The switch point model accounts, in part, for how dynein motors are regulated during ciliary movement. On the basis of this model, supported by key direct experimental observations as well as more recent theoretical and structural studies, we are now poised to understand the mechanics of how ciliary dynein coordination controls axonemal bend formation and propagation.
journal_name
Mol Biol Celljournal_title
Molecular biology of the cellauthors
King SM,Sale WSdoi
10.1091/mbc.E17-07-0483subject
Has Abstractpub_date
2018-03-15 00:00:00pages
698-701issue
6eissn
1059-1524issn
1939-4586pii
mbc.E17-07-0483journal_volume
29pub_type
杂志文章abstract::In the budding yeast Saccharomyces cerevisiae, selection of the bud site determines the axis of polarized cell growth and eventual oriented cell division. Bud sites are selected in specific patterns depending on cell type. These patterns appear to depend on distinct types of marker proteins in the cell cortex; in part...
journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
pub_type: 杂志文章
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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journal_title:Molecular biology of the cell
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