Oligonucleotide conjugated multi-functional adeno-associated viruses.

abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...

journal_title：Scientific reports

authors： Liu Y,Liu C,Wang X,He L,Wan X,Xu Y,Shi Y,Zhang R,Wang F

更新日期：2018-08-27 00:00:00

abstract：:Protective antigen (PA) of Bacillus anthracis is being considered as a vaccine candidate against anthrax and its production has been explored in several heterologous host systems. Since the systems tested introduced adverse issues such as inclusion body formation and endotoxin contamination, the production from B. ant...

journal_title：Scientific reports

authors： Sharma AK,Leppla SH,Pomerantsev AP,Shiloach J

更新日期：2018-10-31 00:00:00

abstract：:Next generation sequencing (NGS) data analysis is highly compute intensive. In-memory computing, vectorization, bulk data transfer, CPU frequency scaling are some of the hardware features in the modern computing architectures. To get the best execution time and utilize these hardware features, it is necessary to tune ...

journal_title：Scientific reports

authors： Kathiresan N,Temanni R,Almabrazi H,Syed N,Jithesh PV,Al-Ali R

更新日期：2017-08-22 00:00:00

abstract：:Transcription activator-like effector (TALE) nuclease (TALEN) is a site-specific nuclease, which can be freely designed and easily constructed. Numerous methods of constructing TALENs harboring different TALE scaffolds and repeat variants have recently been reported. However, the functionalities of structurally differ...

journal_title：Scientific reports

authors： Sakuma T,Ochiai H,Kaneko T,Mashimo T,Tokumasu D,Sakane Y,Suzuki K,Miyamoto T,Sakamoto N,Matsuura S,Yamamoto T

更新日期：2013-11-29 00:00:00

abstract：:The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. It consists of the catalytic subunits IKKα and IKKβ and the regulatory subunit NEMO/IKKγ. Here, we show that the ubiquitin binding domain (UBAN) in NEMO is essential for IKK/NF-κB act...

journal_title：Scientific reports

authors： Vincendeau M,Hadian K,Messias AC,Brenke JK,Halander J,Griesbach R,Greczmiel U,Bertossi A,Stehle R,Nagel D,Demski K,Velvarska H,Niessing D,Geerlof A,Sattler M,Krappmann D

更新日期：2016-01-07 00:00:00

abstract：:The sensitivity of localized surface plasmon resonance (LSPR) of metal nanostructures to adsorbates lends itself to a powerful class of label-free biosensors. Optical properties of plasmonic nanostructures are dependent on the geometrical features and the local dielectric environment. The exponential decay of the sens...

journal_title：Scientific reports

authors： Tadepalli S,Kuang Z,Jiang Q,Liu KK,Fisher MA,Morrissey JJ,Kharasch ED,Slocik JM,Naik RR,Singamaneni S

更新日期：2015-11-10 00:00:00

abstract：:We have developed a computational method that counts the frequencies of unique k-mers in FASTQ-formatted genome data and uses this information to infer the genotypes of known variants. FastGT can detect the variants in a 30x genome in less than 1 hour using ordinary low-cost server hardware. The overall concordance wi...

journal_title：Scientific reports

authors： Pajuste FD,Kaplinski L,Möls M,Puurand T,Lepamets M,Remm M

更新日期：2017-05-31 00:00:00

abstract：:We propose a quantum secure group communication protocol for the purpose of sharing the same message among multiple authorized users. Our protocol can remove the need for key management that is needed for the quantum network built on quantum key distribution. Comparing with the secure quantum network based on BB84, we...

journal_title：Scientific reports

authors： Li ZH,Zubairy MS,Al-Amri M

更新日期：2018-03-01 00:00:00

abstract：:Both chronic calorie restriction (CCR) and intermittent calorie restriction (ICR) have shown anticancer effects. However, the direct evidence comparing ICR to CCR with respect to cancer prevention is controversial and inconclusive. PubMed and Web of Science were searched on November 25, 2015. The relative risk (RR) [9...

journal_title：Scientific reports

authors： Chen Y,Ling L,Su G,Han M,Fan X,Xun P,Xu G

更新日期：2016-09-22 00:00:00

abstract：:The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cance...

journal_title：Scientific reports

authors： Ravoori MK,Singh S,Bhavane R,Sood AK,Anvari B,Bankson J,Annapragada A,Kundra V

更新日期：2016-12-22 00:00:00

abstract：:The majority of colorectal cancer (CRC) arises from precursor lesions known as polyps. The molecular determinants that distinguish benign from malignant polyps remain unclear. To molecularly characterize polyps, we utilized Cancer Adjacent Polyp (CAP) and Cancer Free Polyp (CFP) patients. CAPs had tissues from the res...

journal_title：Scientific reports

authors： Druliner BR,Wang P,Bae T,Baheti S,Slettedahl S,Mahoney D,Vasmatzis N,Xu H,Kim M,Bockol M,O'Brien D,Grill D,Warner N,Munoz-Gomez M,Kossick K,Johnson R,Mouchli M,Felmlee-Devine D,Washechek-Aletto J,Smyrk T,Oberg A,

更新日期：2018-02-16 00:00:00

abstract：:To explore the feasibility of 3D-printed navigation template in proximal femoral varus rotation and shortening osteotomy for older children with developmental dysplasia of the hip (DDH). Between June 2014 and May 2015, navigation templates were designed and used for 12 DDH patients. Surgical information and outcomes w...

journal_title：Scientific reports

authors： Zheng P,Xu P,Yao Q,Tang K,Lou Y

更新日期：2017-03-21 00:00:00

abstract：:Converging evidence from laboratory models pointed that the widely used antidiabetic drug metformin has direct effects on cancer cells. Thus far, relatively little attention has been addressed to the drug exposures used experimentally relative to those achievable clinically. Here, we demonstrated that metformin loaded...

journal_title：Scientific reports

authors： Yoo S,Hou J,Yi W,Li Y,Chen W,Meng L,Si J,Hou X

更新日期：2017-04-21 00:00:00

abstract：:γ-Oryzanol (OZ), which has a lot of beneficial effects, is a mixture of ferulic acid esters of triterpene alcohols (i.e., triterpene alcohol type of OZ (TTA-OZ)) and ferulic acid esters of plant sterols (i.e., plant sterol type of OZ (PS-OZ)). Although it has been reported that OZ is found in several kinds of cereal t...

journal_title：Scientific reports

authors： Ito J,Sawada K,Ogura Y,Xinyi F,Rahmania H,Mohri T,Kohyama N,Kwon E,Eitsuka T,Hashimoto H,Kuwahara S,Miyazawa T,Nakagawa K

更新日期：2019-08-29 00:00:00

abstract：:At the present study, a one-dimensional model for the flat sheet direct contact membrane distillation (DCMD) for desalination purposes is proposed. Flows and membrane properties have been estimated by appropriate temperature-dependent correlations. Results show that the numerical model is in a very good agreement with...

journal_title：Scientific reports

authors： Keshavarzzadeh AH

更新日期：2020-10-08 00:00:00

abstract：:Malachite green is a common environmental pollutant that poses a great threat to non-target organisms, including humans. This study reports the characterization of a bacterial strain, Pseudomonas veronii JW3-6, which was isolated from a malachite green enrichment culture. This strain degraded malachite green efficient...

journal_title：Scientific reports

authors： Song J,Han G,Wang Y,Jiang X,Zhao D,Li M,Yang Z,Ma Q,Parales RE,Ruan Z,Mu Y

更新日期：2020-03-11 00:00:00

abstract：:The number of patients with dry eye disease (DED) is increasing, and DED has become an urgent public health problem. A comorbidity of mental disorders has been reported in DED patients. We hypothesized that physical and psychological stressors impair tear secretion. To examine the relationship between stress loading a...

journal_title：Scientific reports

authors： Sano K,Kawashima M,Imada T,Suzuki T,Nakamura S,Mimura M,Tanaka KF,Tsubota K

更新日期：2019-03-04 00:00:00

abstract：:COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with standard anti-tuberc...

journal_title：Scientific reports

authors： Naftalin CM,Verma R,Gurumurthy M,Hee KH,Lu Q,Yeo BCM,Tan KH,Lin W,Yu B,Seng KY,Lee LS,Paton NI

更新日期：2018-09-10 00:00:00

abstract：:Flow of non-Newtonian fluids through topologically complex structures is ubiquitous in most biological, industrial and environmental settings. The interplay between local hydrodynamics and the fluid's constitutive law determines the distribution of flow paths. Consequently the spatial heterogeneity of the viscous resi...

journal_title：Scientific reports

authors： Eberhard U,Seybold HJ,Secchi E,Jiménez-Martínez J,Rühs PA,Ofner A,Andrade JS Jr,Holzner M

更新日期：2020-07-16 00:00:00

abstract：:Magnetic carboxyl functional nanoporous polymer (MCFNP) was chemically fabricated by incorporation of magnetic Fe3O4 precursor into the carboxyl functional nanoporous polymer (CFNP). The as-synthesized MCFNP was characterized and used as an adsorbent for rapid adsorption removal of methylene blue (MB) from wastewater....

journal_title：Scientific reports

authors： Su H,Li W,Han Y,Liu N

更新日期：2018-04-25 00:00:00

abstract：:Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated a novel Kuma mutant...

journal_title：Scientific reports

authors： Sakano D,Inoue A,Enomoto T,Imasaka M,Okada S,Yokota M,Koike M,Araki K,Kume S

更新日期：2020-07-22 00:00:00

abstract：:A series of β-NaLuF4 crystals were synthesized via a hydrothermal method. Hexagonal phase microdisks, microprisms, and microtubes were achieved by simply changing the amount of citric acid in the initial reaction solution. Pure red upconversion (UC) luminescence can be observed in β-NaLuF4:Yb(3+), Tm(3+), Er(3+) and L...

journal_title：Scientific reports

authors： Lin H,Xu D,Li A,Teng D,Yang S,Zhang Y

更新日期：2016-06-16 00:00:00

abstract：:Biopharming for the production of recombinant pharmaceutical proteins in the mammary gland of transgenic animals is an attractive but laborious alternative compared to mammalian cell fermentation. The disadvantage of the lengthy process of genetically modifying an entire animal could be circumvented with somatic trans...

journal_title：Scientific reports

authors： Wagner S,Thresher R,Bland R,Laible G

更新日期：2015-10-14 00:00:00

abstract：:This study presents analysis of four chimney samples in terms of glycerol dialkyl glycerol tetraether lipids (GDGTs), representing different growing stages of sulfide chimneys at the Deyin hydrothermal field, the southern mid-Atlantic ridge. The modified Bligh-Dyer method was used for lipid extraction and purification...

journal_title：Scientific reports

authors： Li H,Lü X,Tao C,Han T,Hu P,Zhang G,Yu Z,Dong C,Shao Z

更新日期：2018-05-23 00:00:00

abstract：:A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX...

journal_title：Scientific reports

authors： Mo J,Eggers PK,Yuan ZX,Raston CL,Lim LY

更新日期：2016-03-24 00:00:00

abstract：:Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as an antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied the molecular mechanism of osthole in histamine-dependent itch by behavioral test, Ca(2+) imaging, and electrophys...

journal_title：Scientific reports

authors： Yang NN,Shi H,Yu G,Wang CM,Zhu C,Yang Y,Yuan XL,Tang M,Wang ZL,Gegen T,He Q,Tang K,Lan L,Wu GY,Tang ZX

更新日期：2016-05-10 00:00:00

abstract：:Single-cell RNA-seq has been established as a reliable and accessible technique enabling new types of analyses, such as identifying cell types and studying spatial and temporal gene expression variation and change at single-cell resolution. Recently, single-cell RNA-seq has been applied to developing embryos, which of...

journal_title：Scientific reports

authors： Ilsley GR,Suyama R,Noda T,Satoh N,Luscombe NM

更新日期：2020-03-18 00:00:00

abstract：:We conducted extensive molecular dynamics simulations to investigate the thermal conductivity of polycrystalline hexagonal boron-nitride (h-BN) films. To this aim, we constructed large atomistic models of polycrystalline h-BN sheets with random and uniform grain configuration. By performing equilibrium molecular dynam...

journal_title：Scientific reports

authors： Mortazavi B,Pereira LFC,Jiang JW,Rabczuk T

更新日期：2015-08-19 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Nik ME,Malaekeh-Nikouei B,Amin M,Hatamipour M,Teymouri M,Sadeghnia HR,Iranshahi M,Jaafari MR

更新日期：2020-02-27 00:00:00

abstract：:The accurate staging of liver fibrosis is of paramount importance to determine the state of disease progression, therapy responses, and to optimize disease treatment strategies. Non-linear optical microscopy techniques such as two-photon excitation fluorescence (TPEF) and second harmonic generation (SHG) can image the...

journal_title：Scientific reports

authors： Stanciu SG,Xu S,Peng Q,Yan J,Stanciu GA,Welsch RE,So PT,Csucs G,Yu H

更新日期：2014-04-10 00:00:00