Abstract:
:Background A single nucleotide polymorphism, Val66Met, in the Brain Derived Neurotrophic Factor (BDNF) gene has been studied for its role in recovery following stroke. Despite this work, the role of BDNF genotype on long-term recovery is unclear. Additionally, no study has examined its impact on functional mobility. As a result, the purpose of this study was to examine the relationship between BDNF genotype and functional mobility in chronic stroke survivors by first accounting for factors related to the Val66Met polymorphism and post-stroke recovery. Methods Participants 6 months post-stroke completed the Fugl-Meyer Lower Extremity Assessment (FMLE), Yesavage Geriatric Depression Scale (YGDS), 10 meter walk test (SSWS), and BDNF genotype testing. A regression model was used to determine if including genotype (Val or Met) and the genotype's interactions with age, gender, and depression increased the model's fit in predicting functional mobility, as measured by SSWS, after accounting for physical impairment (FMLE) and personal information (age, gender, and YGDS). Results Sixty-three subjects, twenty-two percent of whom had at least one Met allele, were included. Impairment and personal information significantly predicted SSWS (R2 = 0.268, p < 0.001 and ΔR2 = 0.158, p = 0.002, respectively). The addition of genotype and genotype's interactions did not significantly increase the variance accounted for in SSWS (ΔR2 = 0.012, p = 0.27, and ΔR2 = 0.006, p = 0.723, respectively). Conclusions Our results suggest that the Val66Met polymorphism does not predict long-term, functional mobility following stroke. This difference may be due to differences in model variables or a reduced impact of the polymorphism as recovery progresses.
journal_name
Top Stroke Rehabiljournal_title
Topics in stroke rehabilitationauthors
French MA,Morton SM,Pohlig RT,Reisman DSdoi
10.1080/10749357.2018.1437938subject
Has Abstractpub_date
2018-05-01 00:00:00pages
276-280issue
4eissn
1074-9357issn
1945-5119journal_volume
25pub_type
杂志文章abstract:OBJECTIVE:This study investigated whether or not individuals with ataxia from stroke improve their upper extremity motor function with intense motor practice. METHOD:Three individuals with ataxia from chronic stroke completed modified constraint-induced movement therapy (CIMT) protocols. Stroke Participants 1 and 2 co...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr1503-262
更新日期:2008-05-01 00:00:00
abstract:PURPOSE:The rehabilitation of patients who are recovering from severe stroke is associated with a substantial use of resources but limited potential for functional improvement. As a result, these individuals are not perceived as being ideal candidates for inpatient stroke rehabilitation. The objective of this review wa...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章,评审
doi:10.1310/tsr1902-122
更新日期:2012-03-01 00:00:00
abstract::Purpose To use a mixed method design to evaluate how clinicians judge falls in stroke patients as a beneficial event, and to identify patient-specific characteristics associated with beneficial falls. Methods The definition of beneficial falls was based on interviews with six experienced clinicians in stroke rehabilit...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2017.1394631
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The similarities or differences of the three some (physiotherapists, patients, and caregivers) thought about the process of stroke rehabilitation can play a key role in the success of rehabilitation. OBJECTIVE:The aim of this qualitative study was to investigate the perspectives of the three some, with rega...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1179/1074935714Z.0000000042
更新日期:2015-10-01 00:00:00
abstract:UNLABELLED:As hypothermia by immersion can reduce the sensory nerve conduction velocity, this study hypothesized that the reduction of sensory input to the ipsilesional upper extremity (UE) using cryotherapy would reduce the inhibitory activity of the contralesional hemisphere in chronic stroke subjects. OBJECTIVE:In ...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1179/1074935714Z.0000000023
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Providing appropriate and effective information to people with stroke and their families has been identified as a key component to successful practice. Researchers continue to focus on "lack of information" as being the lack of specific technical medical information rather than the communication of practical...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/NPC4-01YV-P66Q-VM9R
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Loss of skeletal muscle mass is one of the main reasons for disability in patients with stroke. However, lower leg muscle wasting has not been studied in acute stroke patients. OBJECTIVE:To investigate the changes in quadriceps muscle thickness in acute non-ambulatory stroke survivors. METHODS:A total of 1...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1179/1945511915Y.0000000002
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:Spasticity poststroke leads to muscle weakness and soft tissue contracture, however, it is not clear how muscle properties change due this motor neural disorder. The purpose was to compare medial gastrocnemius muscle architecture and mechanical properties of the plantarflexor muscles between stroke survivors ...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2016.1210873
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Aerobic training can improve cardiorespiratory fitness in individuals after stroke. However, the effects of short-term and long-term detraining are not well known. OBJECTIVE:To determine the effects of short-term (1-month) and long-term (6-month) detraining on cardiorespiratory fitness (VO2peak) of individu...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2020.1816074
更新日期:2020-09-03 00:00:00
abstract::This article provides the rehabilitation team with some tips concerning how to maximize their chances for successful communication with individuals who have aphasia. These ideas can be applied across the range of settings in which health care is provided. The notions described here can increase the effectiveness of in...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.1996.11754090
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:In response to the need to simultaneously address multiple domains of the International Classification of Functioning, Disability and Health (ICF) in aphasia therapy and to incorporate intensive treatment doses consistent with principles of neuroplasticity, a potentially potent treatment option termed intens...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr2005-379
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Stroke presents with heterogeneous recovery periods, severity, and manifestation of deficits, all of which may adversely impact fitness-to-drive. Little is known about the association between site of lesion and driving performance after stroke. OBJECTIVE:To investigate the association between site of stroke...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1179/1074935714Z.0000000018
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Persons with stroke commonly have serious sequelae requiring long-term medical treatment. They often experience distress, and thus improving quality of life (QOL) has been considered a therapeutic objective in addition to prolonging the patient's life. OBJECTIVE:The aim of this study was to analyze the impa...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1310/tsr2003-226
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:The effects of whole body vibration (WBV) on chronic stroke (CS) patients have been investigated by some previous studies. However, controversy still exists. OBJECTIVE:The objective of this meta-analysis was to review existing studies that assess the effects of WBV training on CS patients. METHODS:We searc...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章,meta分析,评审
doi:10.1179/1074935714Z.0000000005
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:To evaluate the effects of a hand splint with reflex inhibitory characteristics on balance and functional ambulation activities by means of a randomly allocated controlled study. METHODS:Nineteen chronic stroke patients were randomly allocated to the control (n = 9) and study (n = 10) groups to compare the imm...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1310/tsr1803-231
更新日期:2011-05-01 00:00:00
abstract::Stroke remains a leading cause of disability for older adults. While is it well established in the literature that exercise programs can have significant benefit, many stroke survivors do not receive specific recommendations for exercise or lack the motivation to continue exercising following discharge from rehabilita...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr1602-140
更新日期:2009-03-01 00:00:00
abstract::Background Stroke can compromise upper limb performance and influence the individual's participation in real life situations. Objective To investigate how components of body function and activity affect the individuals' self-perception of their participation after stroke. Methods In this observational study, the Inter...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2017.1406177
更新日期:2018-04-01 00:00:00
abstract::In rehabilitation for hemiparesis, one of the goals of an occupational therapist is to practice upper extremity tasks with the recovering individual. The practice is intended to strengthen muscles and refine movements. It also provides examples for the recovering body and brain as they attempt to reestablish the now d...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/GCFE-QA7A-2D24-KHRU
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Many people with mild disability after stroke are physically inactive despite the risk of recurrent stroke. A self-management program may be one strategy to increase physical activity in stroke survivors. OBJECTIVES:To investigate the feasibility of a self-management program, and determine whether self-mana...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2017.1304876
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies suggest that family caregiver well-being (ie, depressive symptoms and life satisfaction) may affect stroke survivor depressive symptoms. We used mediation analysis to assess whether caregiver well-being might be a factor explaining stroke survivor depressive symptoms, after controlling fo...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr2001-44
更新日期:2013-01-01 00:00:00
abstract::The privileging of the substituted judgment standard as the gold standard for surrogate decision making in law and bioethics has constrained the research agenda in end-of-life decision making. The empirical literature is inundated with a plethora of "Newlywed Game" designs, in which potential patients and potential su...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr1404-80
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Many studies have been conducted on the changes in the balance capabilities of stroke patients. However, results regarding the effects of dual-task activities on postural control in these patients have been variable. OBJECTIVE:To evaluate the effects of a short-term memory task on the sway characteristics o...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1179/1074935714Z.0000000039
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:To identify the percentage of persons with stroke resuming therapy within 4 weeks of inpatient rehabilitation discharge, to compare the characteristics of those who did and did not resume therapy, and to determine the predictors of resuming physical (PT), occupational (OT), and speech (ST) therapy. METHOD:Soci...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr1601-80
更新日期:2009-01-01 00:00:00
abstract::In terms of integration of the paretic upper extremity in activities of daily living (ADLs), outcome is poor after stroke. Furthermore, amount of real-world arm use appears only weakly correlated with laboratory motor function scales. Therefore, amount of arm use may depend critically on the location, extent, and type...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr1604-237
更新日期:2009-07-01 00:00:00
abstract::Background: Changes in the paretic-side metabolism post-stroke and quadriceps muscle mechanical properties favour muscle wasting, affecting postural instability and walking impairment. Further clarification is needed in subjects post-stroke who show limited or non-limited community ambulation. Objectives: To analyze b...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2019.1634360
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Attention deficits are common post stroke and result in poorer functional outcomes. This study examined the frequency of attention deficits after incident stroke and their correlates. METHOD:Attention of 94 stroke survivors was assessed using the Bells test, Trails Making Test A/B, 2.4- and 2.0-second trial...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr1706-463
更新日期:2010-11-01 00:00:00
abstract:PURPOSE:Depression after stroke is common and increases morbidity and mortality in the first years after stroke onset. Nevertheless, little is known about the role of psychosocial factors on the etiology of depression in early as well as in the late poststroke stages. The aim of our study was to investigate the influen...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1310/tsr1403-25
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Complex regional pain syndrome type I (CPRS I), is a complex of symptoms characterized by diffuse pain usually with associated swelling, vasomotor instability, and severe functional impairment of the affected extremity in stroke patients. Pain is a prominent feature and is often refractory to var...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.1179/1074935714Z.0000000025
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Participation which entails involvement in life situations and represents a higher level of functioning can be severely restricted after a stroke. This study investigated the impact of social support on participation of stroke survivors in Nigeria. METHODS:Ninety-six community-residing stroke survivors were...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2016.1155279
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Balance is a common mobility limitation following stroke, but determination of the most effective balance-related plan of care can be difficult due to multiple balance impairments that vary between individuals. The Brief-BESTest is a validated outcome measure for balance based on six systems of postural cont...
journal_title:Topics in stroke rehabilitation
pub_type: 杂志文章
doi:10.1080/10749357.2018.1517493
更新日期:2019-01-01 00:00:00