The cycling gonad: retinoic-acid synthesis and degradation patterns during adult zebrafish Danio rerio oogenesis.

Abstract:

:The expression pattern of genes coding for enzymes of the retinoic acid (RA) synthetic and degradation pathways was characterized in adult female zebrafish Danio rerio. Females were conditioned until maturation and post-spawn expression dynamics were determined. A striking upregulation of cyp26b1, but not cyp26a1, was observed following egg deposition, decreasing to initial levels during recovery. A similar, yet lower, fluctuation was observed for aldh1a2 and rdh10a, the enzymes participating in the two-step RA biosynthesis cascade. The present work highlights the dynamics of the adult D. rerio oogenesis and uncovers novel, yet elusive, metabolic contributors. Possible compartmentalized roles for the different gene paralogue isoforms are discussed.

journal_name

J Fish Biol

journal_title

Journal of fish biology

authors

Ruivo R,Capitão A,Castro LFC,Santos MM

doi

10.1111/jfb.13564

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

1051-1064

issue

4

eissn

0022-1112

issn

1095-8649

journal_volume

92

pub_type

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