Abstract:
:The expression pattern of genes coding for enzymes of the retinoic acid (RA) synthetic and degradation pathways was characterized in adult female zebrafish Danio rerio. Females were conditioned until maturation and post-spawn expression dynamics were determined. A striking upregulation of cyp26b1, but not cyp26a1, was observed following egg deposition, decreasing to initial levels during recovery. A similar, yet lower, fluctuation was observed for aldh1a2 and rdh10a, the enzymes participating in the two-step RA biosynthesis cascade. The present work highlights the dynamics of the adult D. rerio oogenesis and uncovers novel, yet elusive, metabolic contributors. Possible compartmentalized roles for the different gene paralogue isoforms are discussed.
journal_name
J Fish Bioljournal_title
Journal of fish biologyauthors
Ruivo R,Capitão A,Castro LFC,Santos MMdoi
10.1111/jfb.13564subject
Has Abstractpub_date
2018-04-01 00:00:00pages
1051-1064issue
4eissn
0022-1112issn
1095-8649journal_volume
92pub_type
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