Elegant Science.

abstract：:The appearance of Cryptococcus gattii in the North American Pacific Northwest (PNW) in 1999 was an unexpected and is still an unexplained event. Recent phylogenomic analyses strongly suggest that this pathogenic fungus arrived in the PNW approximately 7 to 9 decades ago. In this paper, we theorize that the ancestors o...

journal_title：mBio

authors： Engelthaler DM,Casadevall A

更新日期：2019-10-01 00:00:00

abstract：UNLABELLED:Heteroresistance refers to phenotypic heterogeneity of microbial clonal populations under antibiotic stress, and it has been thought to be an allocation of a subset of "resistant" cells for surviving in higher concentrations of antibiotic. The assumption fits the so-called bet-hedging strategy, where a bacte...

journal_title：mBio

authors： Wang X,Kang Y,Luo C,Zhao T,Liu L,Jiang X,Fu R,An S,Chen J,Jiang N,Ren L,Wang Q,Baillie JK,Gao Z,Yu J

更新日期：2014-02-11 00:00:00

abstract：:Symbiotic microorganisms can have a profound impact on the host physiology and behavior, and novel relationships between symbionts and their hosts are continually discovered. A colony of social ants consists of various castes that exhibit distinct lifestyles and is, thus, a unique model for investigating how symbionts...

journal_title：mBio

authors： Koto A,Nobu MK,Miyazaki R

更新日期：2020-04-21 00:00:00

abstract：:Mycoviruses infect fungi, and while most persist asymptomatically, there are examples of mycoviruses having both beneficial and detrimental effects on their host. Virus-infected Saccharomyces and Ustilago strains exhibit a killer phenotype conferring a growth advantage over uninfected strains and other competing yeast...

journal_title：mBio

authors： Applen Clancey S,Ruchti F,LeibundGut-Landmann S,Heitman J,Ianiri G

更新日期：2020-09-01 00:00:00

abstract：:Aspergillosis associated with azole-resistant Aspergillus fumigatus has a mortality rate that can approach 90% in certain patient populations. The best-understood avenue for azole resistance involves changes in the cyp51A gene that encodes the target of azole drugs, lanosterol α-14 demethylase. The most common azole r...

journal_title：mBio

authors： Paul S,Stamnes M,Thomas GH,Liu H,Hagiwara D,Gomi K,Filler SG,Moye-Rowley WS

更新日期：2019-03-12 00:00:00

abstract：UNLABELLED:Nap1 has long been identified as a potential septin regulator in yeasts. However, its function and regulation remain poorly defined. Here, we report functional characterization of Nap1 in the human-pathogenic fungus Candida albicans. We find that deletion of NAP1 causes constitutive filamentous growth and ch...

journal_title：mBio

authors： Huang ZX,Zhao P,Zeng GS,Wang YM,Sudbery I,Wang Y

更新日期：2014-02-04 00:00:00

abstract：:RNA-binding proteins (RBPs) play a major role during control of mRNA localization, stability, and translation and are central to most cellular processes. In the fission yeast Schizosaccharomyces pombe, the multiple K homology (KH) domain RBP Rnc1 downregulates the activity of the cell integrity pathway (CIP) via stabi...

journal_title：mBio

authors： Prieto-Ruiz F,Vicente-Soler J,Franco A,Gómez-Gil E,Sánchez-Marinas M,Vázquez-Marín B,Aligué R,Madrid M,Moreno S,Soto T,Cansado J

更新日期：2020-01-07 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) resists nearly all β-lactam antibiotics that have a bactericidal activity. However, whether the empirically used β-lactams enhance MRSA pathogenicity in vivo remains unclear. In this study, we showed that a cluster of lipoprotein-like genes (lpl, sa2275 to sa2273 [sa2...

journal_title：mBio

authors： Shang W,Rao Y,Zheng Y,Yang Y,Hu Q,Hu Z,Yuan J,Peng H,Xiong K,Tan L,Li S,Zhu J,Li M,Hu X,Mao X,Rao X

更新日期：2019-06-11 00:00:00

abstract：:Bats are reservoirs for many RNA viruses that are highly pathogenic in humans yet relatively apathogenic in the natural host. It has been suggested that differences in innate immunity are responsible. The antiviral OAS-RNase L pathway is well characterized in humans, but there is little known about its activation and ...

journal_title：mBio

authors： Li Y,Dong B,Wei Z,Silverman RH,Weiss SR

更新日期：2019-11-12 00:00:00

abstract：UNLABELLED:Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised individuals. Treatment options for cryptococcosis are limited. Of the two major antifungal drug classes, azoles are active against C. neoformans but exert a fungistatic effect, necessitating long tr...

journal_title：mBio

authors： Huang W,Liao G,Baker GM,Wang Y,Lau R,Paderu P,Perlin DS,Xue C

更新日期：2016-05-10 00:00:00

abstract：:The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriaceae serves as an important indicator that the golden era of antibiotics is unde...

journal_title：mBio

authors： Bulman ZP,Chen L,Walsh TJ,Satlin MJ,Qian Y,Bulitta JB,Peloquin CA,Holden PN,Nation RL,Li J,Kreiswirth BN,Tsuji BT

更新日期：2017-07-25 00:00:00

abstract：:Innate immune response plays a critical role in controlling invading pathogens, but such an immune response must be tightly regulated. Insufficient or overactivated immune responses may lead to harmful or even fatal consequences. To dissect the complex host-parasite interactions and the molecular mechanisms underlying...

journal_title：mBio

authors： Cai B,Wu J,Yu X,Su XZ,Wang RF

更新日期：2017-01-03 00:00:00

abstract：:Malaria parasites have a complex life cycle with multiple developmental stages in mosquito and vertebrate hosts, and different developmental stages express unique sets of genes. Unexpectedly, many transcription factors (TFs) commonly found in eukaryotic organisms are absent in malaria parasites; instead, a family of g...

journal_title：mBio

authors： Zhang C,Li Z,Cui H,Jiang Y,Yang Z,Wang X,Gao H,Liu C,Zhang S,Su XZ,Yuan J

更新日期：2017-12-12 00:00:00

abstract：:Forested ecosystems throughout the world are experiencing increases in the incidence and magnitude of insect-induced tree mortality with large ecologic ramifications. Interestingly, correlations between water quality and the extent of tree mortality in Colorado montane ecosystems suggest compensatory effects from adja...

journal_title：mBio

authors： Mikkelson KM,Brouillard BM,Bokman CM,Sharp JO

更新日期：2017-12-05 00:00:00

abstract：:The type III secretion system (T3SS) forms the functional core of injectisomes, protein transporters that allow bacteria to deliver virulence factors into their hosts for infection, and flagella, which are critical for many pathogens to reach the site of infection. In spite of intensive genetic and biochemical studies...

journal_title：mBio

authors： Terashima H,Kawamoto A,Tatsumi C,Namba K,Minamino T,Imada K

更新日期：2018-06-26 00:00:00

abstract：:Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment of a type IV secretion system (T4SS). However, the mechanism by which the T4SS elicits inflammation remains unknown. Here we show that translocation of the T4SS substrate VceC into host cells induces proinflammatory resp...

journal_title：mBio

authors： de Jong MF,Starr T,Winter MG,den Hartigh AB,Child R,Knodler LA,van Dijl JM,Celli J,Tsolis RM

更新日期：2013-02-19 00:00:00

abstract：:Merozoites formed after asexual division of the malaria parasite invade the host red blood cells (RBCs), which is critical for initiating malaria infection. The process of invasion involves specialized organelles like micronemes and rhoptries that discharge key proteins involved in interaction with host RBC receptors....

journal_title：mBio

authors： Ekka R,Gupta A,Bhatnagar S,Malhotra P,Sharma P

更新日期：2020-10-06 00:00:00

abstract：:Adaptation to alternating CO2 concentrations is crucial for all organisms. Carbonic anhydrases-metalloenzymes that have been found in all domains of life-enable fixation of scarce CO2 by accelerating its conversion to bicarbonate and ensure maintenance of cellular metabolism. In fungi and other eukaryotes, the carboni...

journal_title：mBio

authors： Pohlers S,Martin R,Krüger T,Hellwig D,Hänel F,Kniemeyer O,Saluz HP,Van Dijck P,Ernst JF,Brakhage A,Mühlschlegel FA,Kurzai O

更新日期：2017-01-31 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the CFTR gene and is associated with progressive and ultimately fatal infectious lung disease. There can be considerable variability in disease severity among individuals with the same CFTR mutations, and recent genome-wide association studies have identified secondary ge...

journal_title：mBio

authors： Di Paola M,Park AJ,Ahmadi S,Roach EJ,Wu YS,Struder-Kypke M,Lam JS,Bear CE,Khursigara CM

更新日期：2017-12-19 00:00:00

abstract：:Regulated organization of the chromosome is essential for faithful propagation of genetic information. In the model bacterium Caulobacter crescentus, the replication terminus of the chromosome is spatially arranged in close proximity to the cytokinetic Z-ring during the cell cycle. Although the Z-ring-associated prote...

journal_title：mBio

authors： Ozaki S,Wakasugi Y,Katayama T

更新日期：2021-01-26 00:00:00

abstract：UNLABELLED:A rapid and global emergence of azole resistance has been observed in the pathogenic fungus Aspergillus fumigatus over the past decade. The dominant resistance mechanism appears to be of environmental origin and involves mutations in the cyp51A gene, which encodes a protein targeted by triazole antifungal dr...

journal_title：mBio

authors： Abdolrasouli A,Rhodes J,Beale MA,Hagen F,Rogers TR,Chowdhary A,Meis JF,Armstrong-James D,Fisher MC

更新日期：2015-06-02 00:00:00

abstract：UNLABELLED:The group of proteins known as serine protease autotransporters of Enterobacteriaceae (SPATE) is a growing family of serine proteases secreted to the external milieu by the type V secretion system. Pet toxin and some other SPATE belong to the class 1 cytotoxic SPATE, which have comparable protease strength o...

journal_title：mBio

authors： Nava-Acosta R,Navarro-Garcia F

更新日期：2013-12-10 00:00:00

abstract：:Aspergillus fumigatus is the leading cause of pulmonary fungal diseases. Azoles have been used for many years as the main antifungal agents to treat and prevent invasive aspergillosis. However, in the last 10 years there have been several reports of azole resistance in A. fumigatus and new strategies are needed to com...

journal_title：mBio

authors： Valero C,Colabardini AC,Chiaratto J,Pardeshi L,de Castro PA,Ferreira Filho JA,Silva LP,Rocha MC,Malavazi I,Costa JH,Fill T,Barros MH,Wong SSW,Aimanianda V,Wong KH,Goldman GH

更新日期：2020-06-16 00:00:00

abstract：:Emerging zoonotic viral diseases remain a challenge to global public health. Recent surveillance studies have implicated bats as potential reservoirs for a number of viral pathogens, including coronaviruses and Ebola viruses. Caliciviridae represent a major viral family contributing to emerging diseases in both human ...

journal_title：mBio

authors： Kocher JF,Lindesmith LC,Debbink K,Beall A,Mallory ML,Yount BL,Graham RL,Huynh J,Gates JE,Donaldson EF,Baric RS

更新日期：2018-05-22 00:00:00

abstract：UNLABELLED:Male circumcision reduces female-to-male HIV transmission. Hypothesized mechanisms for this protective effect include decreased HIV target cell recruitment and activation due to changes in the penis microbiome. We compared the coronal sulcus microbiota of men from a group of uncircumcised controls (n = 77) a...

journal_title：mBio

authors： Liu CM,Hungate BA,Tobian AA,Serwadda D,Ravel J,Lester R,Kigozi G,Aziz M,Galiwango RM,Nalugoda F,Contente-Cuomo TL,Wawer MJ,Keim P,Gray RH,Price LB

更新日期：2013-04-16 00:00:00

abstract：:An operon comprising two genes, CA_P0037 and CA_P0036, that encode proteins of unknown function that were previously shown to be highly expressed in acidogenic cells and repressed in solventogenic and alcohologenic cells is located on the pSOL1 megaplasmid of Clostridium acetobutylicum upstream of adhE2 A CA_P0037::in...

journal_title：mBio

authors： Nguyen NP,Linder S,Flitsch SK,Schiel-Bengelsdorf B,Dürre P,Soucaille P

更新日期：2016-10-04 00:00:00

abstract：:In bacteria and eukaryotes alike, proper cellular physiology relies on robust subcellular organization. For the phototrophic purple nonsulfur bacteria (PNSB), this organization entails the use of a light-harvesting, membrane-bound compartment known as the intracytoplasmic membrane (ICM). Here we show that ICMs are spa...

journal_title：mBio

authors： LaSarre B,Kysela DT,Stein BD,Ducret A,Brun YV,McKinlay JB

更新日期：2018-07-03 00:00:00

abstract：UNLABELLED:Filamentous, heterocyst-forming cyanobacteria exchange nutrients and regulators between cells for diazotrophic growth. Two alternative modes of exchange have been discussed involving transport either through the periplasm or through septal junctions linking adjacent cells. Septal junctions and channels in th...

journal_title：mBio

authors： Rudolf M,Tetik N,Ramos-León F,Flinner N,Ngo G,Stevanovic M,Burnat M,Pernil R,Flores E,Schleiff E

更新日期：2015-06-30 00:00:00

abstract：:Protein ubiquitylation regulates not only endocellular trafficking and proteasomal degradation but also the catalytic activity of enzymes. In Saccharomyces cerevisiae, we analyzed the composition of the ubiquitylated proteomes in strains lacking acetyltransferase Gcn5p, Ub-protease Ubp8p, or both to understand their i...

journal_title：mBio

authors： De Palma A,Fanelli G,Cretella E,De Luca V,Palladino RA,Panzeri V,Roffia V,Saliola M,Mauri P,Filetici P

更新日期：2020-08-11 00:00:00

abstract：UNLABELLED:This study demonstrates the prevalence, phylogenetic diversity, and physiology of nitrate-reducing microorganisms capable of utilizing reduced humic acids (HA) as electron donors in agricultural soils. Most probable number (MPN) enumeration of agricultural soils revealed large populations (10(4) to 10(6) cel...

journal_title：mBio

authors： Van Trump JI,Wrighton KC,Thrash JC,Weber KA,Andersen GL,Coates JD

更新日期：2011-07-12 00:00:00