Abstract：
:Ethanol is the most common drug of abuse. It exerts its behavioral effects by acting on widespread neural circuits; however, its impact on glial cells is less understood. We show that Drosophila perineurial glia are critical for ethanol tolerance, a simple form of behavioral plasticity. The perineurial glia form the continuous outer cellular layer of the blood-brain barrier and are the interface between the brain and the circulation. Ethanol tolerance development requires the A kinase anchoring protein Akap200 specifically in perineurial glia. Akap200 tightly coordinates protein kinase A, actin, and calcium signaling at the membrane to control tolerance. Furthermore, ethanol causes a structural remodeling of the actin cytoskeleton and perineurial membrane topology in an Akap200-dependent manner, without disrupting classical barrier functions. Our findings reveal an active molecular signaling process in the cells at the blood-brain interface that permits a form of behavioral plasticity induced by ethanol.
journal_name
Cell Repjournal_title
Cell reportsauthors
Parkhurst SJ,Adhikari P,Navarrete JS,Legendre A,Manansala M,Wolf FWdoi
10.1016/j.celrep.2018.01.049subject
Has Abstractpub_date
2018-02-13 00:00:00pages
1647-1656issue
7issn
2211-1247pii
S2211-1247(18)30081-0journal_volume
22pub_type
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