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The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.

Abstract：

:Circulating CCR2+ monocytes are crucial for maintaining the adult tissue-resident F4/80hiMHCIIhi macrophage pool in the intestinal lamina propria. Here we show that a subpopulation of CCR2-independent F4/80hiMHCIIlow macrophages, which are the most abundant F4/80hi cells in neonates, gradually decline in number in adulthood; these macrophages likely represent the fetal contribution to F4/80hi cells. In colon adenomas of ApcMin/+ mice, F4/80hiMHCIIlow macrophages are not only preserved, but become the dominant subpopulation among tumour-resident macrophages during tumour progression. Furthermore, these pro-tumoural F4/80hiMHCIIlow and F4/80hiMHCIIhi macrophages can self-renew in the tumour and maintain their numbers mostly independent from bone marrow contribution. Analyses of colon adenomas indicate that CSF1 may be a key facilitator of macrophage self-renewal. In summary, the tumour microenvironment creates an isolated niche for tissue-resident macrophages that favours macrophage survival and self-renewal.

journal_name

Nat Commun

journal_title

Nature communications

authors

Soncin I,Sheng J,Chen Q,Foo S,Duan K,Lum J,Poidinger M,Zolezzi F,Karjalainen K,Ruedl C

doi

10.1038/s41467-018-02834-8

subject

Has Abstract

pub_date

2018-02-08 00:00:00

pages

582

issue

1

issn

2041-1723

pii

10.1038/s41467-018-02834-8

journal_volume

9

pub_type

杂志文章

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