Comparative proteomics reveals that YK51, a 4-Hydroxypandurantin-A analogue, downregulates the expression of proteins associated with dengue virus infection.

abstract：:Species interactions are a key component of ecosystems but we generally have an incomplete picture of who-eats-who in a given community. Different techniques have been devised to predict species interactions using theoretical models or abundances. Here, we explore the K nearest neighbour approach, with a special empha...

journal_title：PeerJ

authors： Desjardins-Proulx P,Laigle I,Poisot T,Gravel D

更新日期：2017-08-10 00:00:00

abstract：:Melanoma is a global concern and accounts for the major mortality of skin cancers. Herpes simplex virus thymidine kinase gene with ganciclovir (HSV-TK/GCV) is a promising gene therapy for melanoma. Despite its low efficiency, it is well known for its bystander effect which is mainly mediated by gap junction. In this s...

journal_title：PeerJ

authors： Li H,Du H,Zhang G,Wu Y,Qiu P,Liu J,Guo J,Liu X,Sun L,Du B,Tan Y

更新日期：2019-09-20 00:00:00

abstract：:The Natural Mortality coefficient (M) is a key parameter for stock assessments. The need to establish age-specific natural mortality coefficients is widely recognized because M decreases rapidly over the early stages of the life cycle until it reaches a stable M value around the age-at-maturity. The aim of this study ...

journal_title：PeerJ

authors： Romero-Gallardo S,Velázquez-Abunader I,López-Rocha JA,Garza-Gisholt E

更新日期：2018-07-18 00:00:00

abstract：Background:Except for a few studies with contradictory observations, information is lacking on the possibility of association between DNA mismatch repair (MMR) status and the presence of cancer stem cells in colorectal carcinoma (CRC), two important aspects in colorectal carcinogenesis. Methods:Eighty (40 right-sided ...

journal_title：PeerJ

authors： Cheah PL,Li J,Looi LM,Teoh KH,Ong DB,Arends MJ

更新日期：2018-09-11 00:00:00

abstract：:Relative gene expression data obtained from quantitative RT-PCR (RT-qPCR) experiments are dependent on appropriate normalization to represent true values. It is common to use constitutively expressed endogenous reference genes (RGs) for normalization, but for this strategy to be valid the RGs must be stably expressed ...

journal_title：PeerJ

authors： Ramhøj L,Axelstad M,Svingen T

更新日期：2019-06-26 00:00:00

abstract：:Hypocotyl elongation is a critical sign of seed germination and seedling growth, and it is regulated by multi-environmental factors. Light, temperature, and water potential are the major environmental stimuli, and their regulatory mechanism on hypocotyl growth has been extensively studied at molecular level. However, ...

journal_title：PeerJ

authors： Wang H,Shang Q

更新日期：2020-05-26 00:00:00

abstract：:The consumption of raw fish has increased considerably in the West, since it is said to be potentially healthier than processed fish (for containing omega 3 and 6, essential amino acids and vitamins). However this potential benefit, as well as the taste, value and even the risk of extinction are not the same for all s...

journal_title：PeerJ

authors： Staffen CF,Staffen MD,Becker ML,Löfgren SE,Muniz YCN,de Freitas RHA,Marrero AR

更新日期：2017-11-29 00:00:00

abstract：:Grand Staircase-Escalante National Monument is a federally protected area found in central southern Utah. Designated in 1996 by President William J. Clinton, it was recently reduced in size by President Donald J. Trump in a proclamation that turned the one large monument into three smaller ones. A long-term, standardi...

journal_title：PeerJ

authors： Wilson JS,Kelly M,Carril OM

更新日期：2018-12-04 00:00:00

abstract：:Harmine is the β-carboline alkaloid with the highest concentration in the psychotropic plant decoction Ayahuasca. In rodents, classical antidepressants reverse the symptoms of depression by stimulating neuronal proliferation. It has been shown that Ayahuasca presents antidepressant effects in patients with depressive ...

journal_title：PeerJ

authors： Dakic V,Maciel RM,Drummond H,Nascimento JM,Trindade P,Rehen SK

更新日期：2016-12-06 00:00:00

abstract：:Obesity is demonstrated to be a risk factor in the development of cancers of various organs, such as colon, prostate, pancreas and so on. Leptine (LEP) is the most renowned of the adipokines. As a hormone, it mediates its effect through leptin receptor (LEPR), which is widely expressed in various tissues including col...

journal_title：PeerJ

authors： Al-Shibli SM,Harun N,Ashour AE,Mohd Kasmuri MHB,Mizan S

更新日期：2019-10-02 00:00:00

abstract：Background:Banteng (Bos javanicus d'Alton 1823) are an endangered species, highly sensitive to habitat structure and quality. In many areas, banteng were extinct and needed to be reintroduced to restore their population. Thus, understanding the responses of body condition of reintroduced banteng to their habitat was im...

journal_title：PeerJ

authors： Kongsurakan P,Chaiyarat R,Nakbun S,Thongthip N,Anuracpreeda P

更新日期：2020-04-23 00:00:00

abstract：:The recent publication of a number of high resolution bacterial voltage-gated sodium channel structures has opened the door for the mechanisms employed by these channels to distinguish between ions to be elucidated. The way these channels select between Na(+) and K(+) has been investigated in computational studies, bu...

journal_title：PeerJ

authors： Corry B

更新日期：2013-02-12 00:00:00

abstract：:The stings of bees, wasps, and ants are something that catches the attention of anyone that experiences them. While many recent studies have focused on the pain inflicted by the stings of various stinging wasps, bees, or ants (Hymenoptera: Aculeata), little is known about how the length of the sting itself varies betw...

journal_title：PeerJ

authors： Sadler EA,Pitts JP,Wilson JS

更新日期：2018-05-02 00:00:00

abstract：Background:DegS is a periplasmic serine protease that is considered to be the initiator of the σE stress response pathway, and this protein plays an important role in the regulation of the stress response in E. coli. However, knowledge of the biological function and global regulatory network of DegS in Vibrio cholerae ...

journal_title：PeerJ

authors： Huang J,Chen Y,Chen J,Liu C,Zhang T,Luo S,Huang M,Min X

更新日期：2019-10-23 00:00:00

abstract：OBJECTIVES:Compare the immediate effects of a Neurodynamic Mobilization (NM) treatment or foam roller (FR) treatment after DOMS. DESIGN:Double blind randomised clinical trial. SETTING:The participants performed 100 drop jumps (5 sets of 20 repetitions, separated by 2 min rests) from a 0.5-m high box in a University b...

journal_title：PeerJ

authors： Romero-Moraleda B,La Touche R,Lerma-Lara S,Ferrer-Peña R,Paredes V,Peinado AB,Muñoz-García D

更新日期：2017-10-13 00:00:00

abstract：Background:Acute respiratory distress syndrome (ARDS) is associated with significantly increased risk of death, and early risk stratification may help to choose the appropriate treatment. The study aimed to develop a neural network model by using a genetic algorithm (GA) for the prediction of mortality in patients with...

journal_title：PeerJ

authors： Zhang Z

更新日期：2019-09-16 00:00:00

abstract：:The canopy-forming, intertidal brown (Phaeophyceae) seaweed Fucus guiryi is distributed along the cold-temperate and warm-temperate coasts of Europe and North Africa. Curiously, an isolated population develops at Punta Calaburras (Alboran Sea, Western Mediterranean) but thalli are not present in midsummer every year, ...

journal_title：PeerJ

authors： Melero-Jiménez IJ,Salvo AE,Báez JC,Bañares-España E,Reul A,Flores-Moya A

更新日期：2017-11-14 00:00:00

abstract：Background:Introduced predators at seabird colonies and parasites may have lethal and/or sub-lethal consequences for bird populations. We assessed the potential sub-lethal negative effects of these stressors in a native seabird listed as vulnerable in its south-eastern pacific distribution. This study was conducted in ...

journal_title：PeerJ

authors： Luna N,Varela AI,Luna-Jorquera G,Brokordt K

更新日期：2020-07-08 00:00:00

abstract：:Background. Massively parallel sequencing technology is being used to sequence highly diverse populations of DNA such as that derived from heterogeneous cell mixtures containing both wild-type and disease-related states. At the core of such molecule tagging techniques is the tagging and identification of sequence read...

journal_title：PeerJ

authors： Andrews TD,Jeelall Y,Talaulikar D,Goodnow CC,Field MA

更新日期：2016-05-24 00:00:00

abstract：:Brunei Bay, which receives freshwater discharge from four major rivers, namely Limbang, Sundar, Weston and Menumbok, hosts a luxuriant mangrove cover in East Malaysia. However, this relatively undisturbed mangrove forest has been less scientifically explored, especially in terms of vegetation structure, ecosystem serv...

journal_title：PeerJ

authors： Satyanarayana B,M Muslim A,Izzaty Horsali NA,Mat Zauki NA,Otero V,Nadzri MI,Ibrahim S,Husain ML,Dahdouh-Guebas F

更新日期：2018-02-20 00:00:00

abstract：Background/Aims:Medical and behavioral needs are relevant in organizing and providing support strategies that improve the quality of life for children, along with their families. The present study aims to examine the impact of medical and behavioral needs on the need for support of children with disabilities. Methods:...

journal_title：PeerJ

authors： Arias VB,Aguayo V,Verdugo MA,Amor AM

更新日期：2020-09-15 00:00:00

abstract：:Rhynchosauria is a group of archosauromorph reptiles abundant in terrestrial ecosystems of the Middle Triassic. Mesosuchus is one of the earliest and basalmost rhynchosaurs, playing an important role not only for the understanding of the evolution of the group as a whole, but also of archosauromorphs in general. The b...

journal_title：PeerJ

authors： Sobral G,Müller J

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:The human microbiota plays a key role in health and disease, and bacteriocins, which are small, bacterially produced, antimicrobial peptides, are likely to have an important function in the stability and dynamics of this community. Here we examined the density and distribution of the subclass I lantibiotic m...

journal_title：PeerJ

authors： Walsh CJ,Guinane CM,O' Toole PW,Cotter PD

更新日期：2017-04-27 00:00:00

abstract：:The objective of this study was to quantify consumption of clothianidin-treated corn seed by birds following standard planting practices. Based on post-planting seed counts on 21 fields in southwestern Ontario, Canada, between 29 and 813 seeds/ha (mean of 224 ± 167 (SD)) were estimated to remain on the soil surface im...

journal_title：PeerJ

authors： McGee S,Whitfield-Aslund M,Duca D,Kopysh N,Dan T,Knopper L,Brewer L

更新日期：2018-11-07 00:00:00

abstract：:Biological control, a globally-important ecosystem service, can provide long-term and broad-scale suppression of invasive pests, weeds and pathogens in natural, urban and agricultural environments. Following (few) historic cases that led to sizeable environmental up-sets, the discipline of arthropod biological control...

journal_title：PeerJ

authors： Wyckhuys KAG,Wongtiem P,Rauf A,Thancharoen A,Heimpel GE,Le NTT,Fanani MZ,Gurr GM,Lundgren JG,Burra DD,Palao LK,Hyman G,Graziosi I,Le VX,Cock MJW,Tscharntke T,Wratten SD,Nguyen LV,You M,Lu Y,Ketelaar JW,Goergen G

更新日期：2018-10-19 00:00:00

abstract：:Live trapping is a common tool used to assess demography of small mammals. However, live-trapping is often expensive and stressful to captured individuals. Thus, assessing the relative tradeoffs among study goals, project expenses, and animal well-being is necessary. Here, we evaluated how apparent bias and precision ...

journal_title：PeerJ

authors： Weldy MJ,Wilson TM,Lesmeister DB,Epps CW

更新日期：2019-10-03 00:00:00

abstract：Background:Human population growth has led to biodiversity declines in tropical cities. While habitat loss and fragmentation have been the main drivers of urban biodiversity loss, man-made interventions to reduce health risks have also emerged as an unintentional threat. For instance, insecticide fogging to control mos...

journal_title：PeerJ

authors： Lee NSM,Clements GR,Ting ASY,Wong ZH,Yek SH

更新日期：2020-10-01 00:00:00

abstract：:Madagascar's subfossil record preserves a diverse community of animals including elephant birds, pygmy hippopotamus, giant lemurs, turtles, crocodiles, bats, rodents, and carnivorans. These fossil accumulations give us a window into the island's past from 80,000 years ago to a mere few hundred years ago, recording the...

journal_title：PeerJ

authors： Mathews JC,Samonds KE

更新日期：2016-09-15 00:00:00

abstract：:We study the glycosylation processes that convert initially toxic substrates to nutritionally valuable metabolites in the flavonoid biosynthesis pathway of tomato (Solanum lycopersicum) seedlings. To estimate the reaction rates we use ordinary differential equations (ODEs) to model the enzyme kinetics. A popular choic...

journal_title：PeerJ

authors： Astola L,Stigter H,Gomez Roldan MV,van Eeuwijk F,Hall RD,Groenenboom M,Molenaar JJ

更新日期：2016-09-20 00:00:00

abstract：Background:The Mini-IPIP scales (Donellan et al., 2006) are possibly one of the most commonly used short inventories for measuring the Big Five Factors of personality. In this study, we aimed to investigate the psychometric properties of two Mini-IPIP Spanish short forms, one balanced and one positively wording (PW). ...

journal_title：PeerJ

authors： Martínez-Molina A,Arias VB

更新日期：2018-09-13 00:00:00