Basophil Membrane Expression of Epithelial Cytokine Receptors in Patients with Severe Asthma.

abstract：:HIV-1 RNA has become the standard for monitoring antiretroviral therapies. Dogma predicts, however, that a viral protein like p24 should be at least as good a marker of HIV disease activity, provided that it is measured with sufficient sensitivity and accuracy. Simple modifications including use of a more efficient vi...

journal_title：International archives of allergy and immunology

authors： Schüpbach J

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Food allergy to wheat-derived foodstuffs is on the rise. Tri a 14, a wheat flour lipid transfer protein (LTP) allergen, has been described as a major allergen associated with baker's asthma and wheat food allergy. Cross-reactivity among LTP allergens leads to the so-called 'LTP syndrome'. METHODS:Eight adul...

journal_title：International archives of allergy and immunology

authors： Palacin A,Bartra J,Muñoz R,Diaz-Perales A,Valero A,Salcedo G

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Lactobacillus casei is a nonpathogenic gram-positive bacterium widely used in dairy products and has been shown to enhance the cellular immunity of the host. METHODS:To examine the inhibitory effect of L. casei on IgE production, splenocytes obtained from ovalbumin (OVA)-primed BALB/c mice were restimulated...

journal_title：International archives of allergy and immunology

authors： Shida K,Makino K,Morishita A,Takamizawa K,Hachimura S,Ametani A,Sato T,Kumagai Y,Habu S,Kaminogawa S

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:House dust mite (HDM)-sensitive allergic rhinitis is a perennial rhinitis with persistent nasal inflammation. Currently, there are no reliable parameters to monitor the severity of perennial allergic rhinitis. The purpose of this study was to evaluate correlations between clinical and laboratory parameters i...

journal_title：International archives of allergy and immunology

authors： Klaewsongkram J,Ruxrungtham K,Wannakrairot P,Ruangvejvorachai P,Phanupak P

更新日期：2003-09-01 00:00:00

abstract：:Amino acid sequencing of the major mite allergen Der fII purified from mite body extract revealed that it is a mixture of at least two variants. Substitutions were found only at positions in which amino acid variations were predicted from the nucleotide sequences of three cloned cDNAs. When cDNAs corresponding to the ...

journal_title：International archives of allergy and immunology

authors： Nishiyama C,Yuuki T,Usui Y,Iwamoto N,Okumura Y,Okudaira H

更新日期：1994-09-01 00:00:00

abstract：:Hypersensitivity to latex proteins has been reported with increasing frequency in recent years. Elevated levels of latex specific IgE have been detected in the majority of these patients. Severe anaphylaxis and death resulting from latex exposure has also been reported. Nevertheless, the immune mechanism of latex alle...

journal_title：International archives of allergy and immunology

authors： Kurup VP,Kumar A,Choi H,Murali PS,Resnick A,Kelly KJ,Fink JN

更新日期：1994-01-01 00:00:00

abstract：:We carried out a cross-sectional chronobiological investigation on blood histamine, thyroid histamine and thyroid mast cell number in Wistar rats. Daily, blood histamine varied from 0.38 +/- 0.01 (12.00 h) to 0.60 +/- 0.01 mg/g wet weight (20.00 h) and thyroid histamine from 21.2 +/- 1.19 (04.00 h) to 38.3 +/- 1.54 mg...

journal_title：International archives of allergy and immunology

authors： Catini C,Miliani A,Macchi C

更新日期：1994-12-01 00:00:00

abstract：:Factors are discussed as potential diagnostic parameters of atopic disorders. The amounts of sCD23 in sera from newborn children (n = 4,329) were determined by radioimmunoassay with monoclonal antibodies specific for CD23. The sCD23 levels ranged between 0 and 81.5 ng/ml of CD23-specific mAb. Furthermore, the sera of ...

journal_title：International archives of allergy and immunology

authors： Bujanowski-Weber J,Knöller I,Wahn U,König W

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Airway closure is frequently observed in human asthma. However, limited information exists on the factors that cause this condition. In this study, an allergic cynomolgus monkey model was used to characterize the condition of airway closure and assess the contribution of histamine H1 receptors to this respon...

journal_title：International archives of allergy and immunology

authors： Skeans S,Lamca JE,House A,Celly CS,Hey JA,Chapman RW

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Antiphospholipid antibodies (aPL) show great heterogeneity. Different phospholipids, with or without protein cofactor(s), and phospholipid binding proteins alone have been proposed as the target molecules for aPL. In order to determine the influence of phospholipid degradation products on the binding of aPL,...

journal_title：International archives of allergy and immunology

authors： Bozic B,Kveder T,Stegnar M,Morosini-Berus E,Kos-Golja M,Peternel P,Rozman B

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Diethylhexyl phthalate (DEHP) and diisononyl phthalate (DINP), two commonly used plasticizers in flexible polyvinylchloride formulations, have potentially adverse effects on human health. However, the influence of these diphthalates on allergic responses remains unclear. In this study we examined the effects...

journal_title：International archives of allergy and immunology

authors： Lee MH,Park J,Chung SW,Kang BY,Kim SH,Kim TS

更新日期：2004-07-01 00:00:00

abstract：:Der f2 protein in a highly antigenic form was directly expressed in bacteria. Plasmid pFLU11 derived from pKK233-2 was designed to express methionyl-Der f2 under the control of the trc promoter and it has the replication origin of pUC118 instead of its original to increase the copy number. This expression plasmid dire...

journal_title：International archives of allergy and immunology

authors： Iwamoto N,Nishiyama C,Yasuhara T,Saito A,Yuuki T,Okumura Y,Okudaira H

更新日期：1996-04-01 00:00:00

abstract：:Bronchial asthma, characterized by eosinophilic inflammation in airways, may involve Th2-type cytokines such as interleukin-5 (IL-5). IL-12, a newly established cytokine, induces IFN-gamma production, which may have a regulatory effect on the production of Th2-type cytokines. We examined the effects of IL-12 on the pr...

journal_title：International archives of allergy and immunology

authors： Okano Y,Nakamura Y,Sano T,Azuma M,Sone S

更新日期：1998-01-01 00:00:00

abstract：:Fibroblast-derived growth factors like SCF are able to upregulate the expression of mast cell characteristics in human multilineage hematopoietic progenitor cells. Other factors, like GM-CSF, have been reported to inhibit this process, probably by the competitive recruitment of cells not belonging to the mast cell lin...

journal_title：International archives of allergy and immunology

authors： Welker P,Grabbe J,Zuberbier T,Henz BM

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...

journal_title：International archives of allergy and immunology

authors： Koike Y,Sato S,Yanagida N,Asaumi T,Ogura K,Ohtani K,Imai T,Ebisawa M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:T cells are key regulators of immunologic disease parameters. However, their contribution to the process of tissue remodeling is ill defined. In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pa...

journal_title：International archives of allergy and immunology

authors： Wohlfahrt JG,Kunzmann S,Menz G,Kneist W,Akdis CA,Blaser K,Schmidt-Weber CB

更新日期：2003-08-01 00:00:00

abstract：:Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...

journal_title：International archives of allergy and immunology

authors： Hogan SP

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition. METHODS:We performed a retrospective review by a blinded...

journal_title：International archives of allergy and immunology

authors： Hagan JB,Park MA,Kita H,Campeau NG

更新日期：2010-01-01 00:00:00

abstract：:Phosphoinositide 3-kinases (PI3Ks) are known to be involved in a variety of cellular responses such as cell survival, proliferation, differentiation and cell migration. Recently, PI3Ks have been associated with the pathogenesis of asthma because various immune cells regulate allergic responses. Among the three classes...

journal_title：International archives of allergy and immunology

authors： Takeda M,Ito W,Tanabe M,Ueki S,Kihara J,Kato H,Tanigai T,Kayaba H,Sasaki T,Chihara J

更新日期：2010-01-01 00:00:00

abstract：:Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...

journal_title：International archives of allergy and immunology

authors： Goddard J,Hasenkampf N,Edwards KT,de Shazo R,Embers ME

更新日期：2013-01-01 00:00:00

abstract：:It has been well documented that environmental factors such as antigen-presenting cells and related cytokines can affect the development of T-helper cells. The purpose of this study was to investigate the role of different antigen-presenting cells on T-cell development. Ovalbumin (OVA) combined with complete Freud's a...

journal_title：International archives of allergy and immunology

authors： Chuang YH,Chiang BL,Chou CC,Hsieh KH

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Pre-clinical and clinical studies have evaluated the efficacy of probiotics in allergy. However, predictive in vitro systems for rational strain selection are still missing. METHODS:We developed a novel in vitro screening system for the characterization of probiotics with anti-allergic potential. In this mo...

journal_title：International archives of allergy and immunology

authors： Holvoet S,Zuercher AW,Julien-Javaux F,Perrot M,Mercenier A

更新日期：2013-01-01 00:00:00

abstract：:Thioredoxin (TRX) is a redox-active protein that regulates reactive oxidative metabolism and plays a crucial role in the antioxidant system in regulating the reduction/oxidation balance by scavenging reactive oxygen species, which is implicated in the mechanism of asthma. As for the mechanisms by which TRX exerts its ...

journal_title：International archives of allergy and immunology

authors： Ito W,Kobayashi N,Takeda M,Ueki S,Kayaba H,Nakamura H,Yodoi J,Chihara J

更新日期：2011-01-01 00:00:00

abstract：:In the present study, we investigated the role of resident peritoneal cells as well as the mediators involved in the eosinophil migration induced by large volumes of physiological saline. Two consecutive intraperitoneal injections of saline given 48 h apart, induced a selective recruitment of eosinophils into the cavi...

journal_title：International archives of allergy and immunology

authors： Oliveira SH,Faccioli LH,Cunha FQ,Ferreira SH

更新日期：1994-08-01 00:00:00

abstract：:A previous study described clinical and pathological manifestations observed in 49 chimeras produced by replacing a small fragment of the neural tube of a chicken embryo by a similar fragment from a Japanese quail embryo. Predominant antibodies in sera of these birds were directed against xenogeneic antigens which are...

journal_title：International archives of allergy and immunology

authors： Yang G,Albini B,Milgrom F

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:We reported on the constitutive interferon-gamma receptor (IFN-gammaR) expression on eosinophils. But signal transduction through IFN-gammaR on eosinophils remains to be elucidated. In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN-gammaR conjugation...

journal_title：International archives of allergy and immunology

authors： Ochiai K,Ishihara C,Tomioka H

更新日期：1999-02-01 00:00:00

abstract：:Long-term birth cohort studies are essential to understanding the life course and childhood predictors of allergy and the complex interplay between genes and the environment (including lifestyle and socioeconomic determinants). Over 100 cohorts focusing on asthma and allergy have been initiated in the world over the p...

journal_title：International archives of allergy and immunology

authors： Bousquet J,Anto J,Sunyer J,Nieuwenhuijsen M,Vrijheid M,Keil T,MeDALL Study Group.,CHICOS Study Group.,ENRIECO Study Group.,GA²LEN Study Group.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) play a decisive role in the induction of allergen-induced Th1 and Th2 responses. Since the induction of allergen-specific Th1 responses has shown to inhibit allergen-induced Th2-type inflammation, in this study we investigated whether manipulated myeloid-derived DC pulsed with the specif...

journal_title：International archives of allergy and immunology

authors： Trujillo-Vargas CM,Ramirez-Pineda JR,Palmetshofer A,Grunewald S,Moll H,Berberich C,Erb KJ

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to...

journal_title：International archives of allergy and immunology

authors： Matsumoto M,Konno S,Kimura H,Takei N,Kimura H,Shimizu K,Goudarzi H,Suzuki M,Hashino S,Nishimura M

更新日期：2018-01-01 00:00:00

abstract：:The JAK (Janus kinase) family of protein tyrosine kinases and the STATs (signal transducers and activators of transcription) have been shown to be activated in response to a number of cytokines and growth factors. In this study, we evaluated the activation of JAK/STAT pathway upon human interleukin-5 (hIL-5) stimulati...

journal_title：International archives of allergy and immunology

authors： Ogata N,Kikuchi Y,Kouro T,Tomonaga M,Takatsu K

更新日期：1997-10-01 00:00:00