Abstract:
BACKGROUND:Although the main treatments of inflammatory bowel disease (IBD) aim at the induction and maintenance of clinical remission, several studies have demonstrated inflammation still present in clinical remission. The goal of this study was to analyze the gene expression profiles between the pediatric IBD and control samples, aiming to further investigate the underlying therapeutic target in remission. METHODS:Gene expression profiles data of GSE33943 were downloaded from Gene Expression Omnibus, which included 45 pediatric IBD samples and 13 control samples. The differentially expressed genes (DEGs) between IBD and control samples were identified by LIMMA package in R and the function of DEGs were predicted by Gene Ontology and KEGG pathway enrichment analyses using GeneAnswer package. Furthermore, a protein‒protein interaction (PPI) network was constructed through the STRING database and functional module was obtained using ClusterONE. RESULTS:A total of 224 DEGs were screened between IBD and control samples. These DEGs (e.g. up-regulated FAS and down-regulated CCL5) were mainly enriched in cytokine‒cytokine receptor interaction and chemokine signaling pathway. In addition, some hub genes (e.g. up-regulated PSMA2 and PSMA6) were obtained through PPI network and functional module. These two genes were involved in Proteasome alpha-subunit and conserved site by functional module analysis. CONCLUSIONS:The immune and Proteasome mechanisms are still active during remission and FAS, PMSF6 and PMSF2 may be underlying targets for therapy of this disease.
journal_name
Minerva Pediatrjournal_title
Minerva pediatricaauthors
Liu D,Sun H,Li W,Zhu Y,Li J,Jin Sdoi
10.23736/S0026-4946.18.04997-6subject
Has Abstractpub_date
2018-01-29 00:00:00eissn
0026-4946issn
1827-1715pii
S0026-4946.18.04997-6pub_type
杂志文章abstract::Congenital diaphragmatic hernia (CDH) remains one of the major challenges in neonatal surgery. Survival rate has increased in the last decades mainly due to perinatal care and surgical technique improvements. Classically, a laparotomy has been performed after cardiovascular and respiratory stabilization. Introduction ...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4946.17.05110-6
更新日期:2018-06-01 00:00:00
abstract::Providing optimal mechanical ventilation to critically-ill children remains a challenge. Patient-ventilator dyssynchrony results frequently with numerous deleterious consequences on patient outcome including increased requirement for sedation, prolonged duration of ventilation, and greater imposed work of breathing. M...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:2016-12-01 00:00:00
abstract::Both systolic and diastolic dysfunction in the pediatric population can be identified by bedside echocardiography and can guide therapy and evaluate response to therapy. Isolated diastolic dysfunction is rare in children; however many conditions can lead to systolic dysfunction. In this review various echocardiographi...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:This study aims to evaluate the association of consuming healthy foods with anthropometric measures and blood pressure (BP) in a national sample of Iranian children and adolescents. METHODS:This nationwide study was conducted in 2011-2012 among 13,486 students, aged 6-18 years, selected by multistage cluste...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.16.04337-1
更新日期:2019-10-01 00:00:00
abstract::Contiguous gene deletion syndromes: the importance of an accurate genetic definition for a careful clinical monitoring. Contiguous gene deletion syndromes are so named because the deletion manifests as a distinctive cluster of otherwise unrelated single-gene disorders in the same subject. An accurate genetic definitio...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:2010-06-01 00:00:00
abstract::Some reports have been published concerning the positive effects of using intravenous immunoglobulins as immunotherapy and immunoprophylaxis of infection in newborns. The safety and efficacy of intravenously administered gamma globulins 7S versus 5S was evaluated in 64 high-risk neonates. The infants admitted to this ...
journal_title:Minerva pediatrica
pub_type: 临床试验,杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::The diagnosis of fetal tachyarrhythmia during a routine ultrasound scan imposes a continuous monitoring of fetal heart function through ECG and M-mode echocardiography. Since fetal dysrhythmia can lead to non-immune hydrops or to fetal death a correct diagnosis and an adequate intrauterine therapy are fundamentally im...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1993-05-01 00:00:00
abstract:AIM:Childhood leukaemia treatment contains multiple chemotherapeutic agents in high doses that can cause severe toxic effects on heart and other vital organs. In this respect patients taking cancer chemotherapy are followed for these adverse effects. Echocardiographic myocardial performance index (MPI) was reported as ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2007-04-01 00:00:00
abstract::The present study concerns with anthropometric and nutritional data collected in the school population of a small rural town in Lazio. We studied 368 school-children of both sexes, belonging to the following age groups: from 7 to 8 years, 9 to 10 years, 11 to 12 years, 13 to 14 years. The technique of evaluation of ob...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract:BACKGROUND:Since most of the children observed in our Centre present enuresis with voiding disturbance, we carried out a study where these patients were treated with the DDAVP + Oxybutinin association. METHODS:We have treated 89 children with enuresis and voiding disturbances (urge incontinence, voiding urgency, urina...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::The paper illustrates the characteristics of external fixators (EF) (Wagner, FEA, Ilizarov) regularly used in pediatric surgery. Attention is focused on the indications for their use in orthopedics and traumatology during the developmental age. In conclusion, their use, even though in traumatology this is more restric...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Cystic fibrosis (CF) is an inherited, prematurely lethal rare disease affecting more than 85,000 people worldwide. CF is caused by more than 2000 loss-of-function mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). This review summarizes recent advances in the etiological t...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4946.19.05506-3
更新日期:2019-06-01 00:00:00
abstract:AIM:To evaluate the prevalence of ultrasound diagnosis of adenomyosis and endometriosis in young women complaining of pelvic pain and to find the symptoms and clinical characteristics associated with these diseases in young women. METHODS:Cross-sectional study, including 100 young women (14-24 years) with a history of...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.20.05842-9
更新日期:2020-06-16 00:00:00
abstract::Infants born prematurely before 37 weeks of gestational age (GA) have particular anatomical, immunological and metabolic characteristics that predispose them, even in the absence of diseases at birth, to severe morbidity. Respiratory syncytial virus (RSV) is the leading cause of hospitalization for lower respiratory t...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4946.18.05300-8
更新日期:2018-12-01 00:00:00
abstract::Testosterone, LH, FSH, blood levels at birth were determined in 40 Italian true cryptorchid , 12 pseudo-cryptorchid and 71 healthy newborns. Testosterone concentrations were interpreted according to the localisation of the retained testicles. A greater incidence of spontaneous remission of the cryptorchidism was found...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The care of adolescents suffering from high risk disease is a demanding challenge. At times, adolescents may well be too old for the pediatrician and Pediatric Units, and yet too young for the adult practitioner. A dedicated approach that builds on the insight deriving from special attention to, and reflection on the ...
journal_title:Minerva pediatrica
pub_type: 社论
doi:
更新日期:2011-04-01 00:00:00
abstract::Joint hypermobility refers to the ability that a joint has to move beyond its normal range of motion. It is common in the general population, particularly in children. While many individuals manifesting joint hypermobility are healthy, this feature can accompany a wide range of symptoms and systemic disorders, whose m...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.20.05766-7
更新日期:2020-04-01 00:00:00
abstract:AIM:The objective of this paper is an empirical analysis of mother-infant feeding interactions through an observational instrument (Feeding Scale), which is applied to the videotape of a feeding session. METHODS:Three samples of mothers and their children have been examined (104 couples with children ranging in age fr...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:2003-06-01 00:00:00
abstract::Little is known about the overlapping symptoms and comorbidity of pediatric bipolar disorder (BD) and pervasive developmental disorders (PDD) in youth. The aim of this study was to clearly differentiate the symptoms, understand the prevalence and patterns of comorbid presentations, as well as to provide a summary of e...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate the potential of dexfenfluramine (dF) for reducing cardiovascular risk factors and improving compliance towards diet in a group of young patients hospitalized for essential obesity of high degree (BMI > or = 35). METHODS:103 adolescents (mean age 15.4 +/- 0.2) partic...
journal_title:Minerva pediatrica
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-03-01 00:00:00
abstract::This paper reports a case of pyloric duplication, an extremely rare abnormality usually discovered during infancy. Clinical findings involved mainly symptoms of obstruction and radiological evaluation included abdominal US, plain radiography and CT imaging. Pyloric duplication was diagnosed by US and confirmed by CT s...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2006-08-01 00:00:00
abstract::Distinguishing between constitutional delay of growth and puberty (CDGP) and congenital hypogonadotropic hypogonadism (CHH) may be challenging. CDGP and CHH appear to belong to the same clinical spectrum (with low sex hormones and low LH and FSH), although one is classically transient and known as a self-limited form ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.20.05860-0
更新日期:2020-08-01 00:00:00
abstract:BACKROUND:In the present study we investigated the levels of proapoptotic Caspase-9 and antiapoptotic Bcl-2 proteins in the sera of children and adolescents with idiopathic epilepsy and tried to relate the findings to the patients clinical parameters. METHODS:This retrospective study consisted of 118 children and adol...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:10.23736/S0026-4946.17.04787-9
更新日期:2017-06-22 00:00:00
abstract:BACKGROUND:This study evaluates endoscopic and quality of life (QoL) outcomes in two groups, composed by both allergic (A) and non-allergic (N-A) adolescents undergoing septoplasty with concurrent turbinate surgery by radiofrequency treated after surgery with nasal spray containing liposomes and vitamins A and E. METH...
journal_title:Minerva pediatrica
pub_type: 杂志文章,随机对照试验
doi:10.23736/S0026-4946.16.04600-4
更新日期:2017-02-01 00:00:00
abstract::The lipidaemic profile has been evaluated in a series of 603 healthy children aged 13-14, within a programme for the prevention of atherosclerotic disease commenced in November 1980 at Health Unit 66 of the Region of Piedmont. Hyperlipaemia is among the environmental risk factors for ATS and more than any of the other...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract:AIM:Aim of this study is to evaluate anxiety and temperament characteristics in developmental age subjects who practised agonistic sport (individual or team sports) in comparison with a sample group of subjects who practice no agonistic sports. METHODS:Sixty subjects aged from 10 to 16 years were enrolled in the study...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::In 1967 a baby was observed who presented post-natal progressive growth deficit, mental retardation, craniofacial dysmorphias and other malformations which didn't form part of the syndromes till then known. However the first description of patients with this combination of anomalies dates back to 1981, when Niikawa an...
journal_title:Minerva pediatrica
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-01 00:00:00
abstract::Severe atopic dermatitis causes major impairment in the life of both children and their parents. Generally, symptoms can be controlled with emollients, topical steroids, antibiotics, antihistaminic but some patients remain intensely ill and may require treatment with systemic steroids and so on. Cyclosporin has been f...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2004-04-01 00:00:00
abstract:AIM:To test the impact of a public health model to implement HIV pediatric care in Limited Resource Settings. METHODS:A retrospective study on the clinical files of 679 Mozambican children (mean age 4.4 years; SD 3.2), has been carried out. The pediatric patients received HAART (Highly Active Anti-Retroviral Therapy) ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:A drug-related problem (DRP) may be defined as "an event or circumstance involving drug therapy that actually or potentially interferes with the desired health outcome". Our aim was to determine the frequency and characteristics of DRPs in pediatric patients admitted to a tertiary cardiac care center in the ...
journal_title:Minerva pediatrica
pub_type: 杂志文章
doi:
更新日期:2016-04-01 00:00:00