Abstract：
:Internal therapy with α-emitters should be well suited for micrometastatic disease. Radium-224 emits multiple α-particles through its decay and has a convenient 3.6 days of half-life. Despite its attractive properties, the use of 224 Ra has been limited to bone-seeking applications because it cannot be stably bound to a targeting molecule. Alternative delivery systems for 224 Ra are therefore of considerable interest. In this study, calcium carbonate microparticles are proposed as carriers for 224 Ra, designed for local therapy of disseminated cancers in cavitary regions, such as peritoneal carcinomatosis. Calcium carbonate microparticles were radiolabeled by precipitation of 224 Ra on the particle surface, resulting in high labeling efficiencies for both 224 Ra and daughter 212 Pb and retention of more than 95% of these nuclides for up to 1 week in vitro. The biodistribution after intraperitoneal administration of the 224 Ra-labeled CaCO3 microparticles in immunodeficient mice revealed that the radioactivity mainly remained in the peritoneal cavity. In addition, the systemic distribution of 224 Ra was found to be strongly dependent on the amount of administered microparticles, with a reduced skeletal uptake of 224 Ra with increasing dose. The results altogether suggest that the 224 Ra-labeled CaCO3 microparticles have promising properties for use as a localized internal α-therapy of cavitary cancers.
journal_name
J Labelled Comp Radiopharmjournal_title
Journal of labelled compounds & radiopharmaceuticalsauthors
Westrøm S,Malenge M,Jorstad IS,Napoli E,Bruland ØS,Bønsdorff TB,Larsen RHdoi
10.1002/jlcr.3610subject
Has Abstractpub_date
2018-05-30 00:00:00pages
472-486issue
6eissn
0362-4803issn
1099-1344journal_volume
61pub_type
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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doi：10.1002/jlcr.3772
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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journal_title：Journal of labelled compounds & radiopharmaceuticals
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