Abstract:
:Obesity has been linked with structural and functional brain changes. However, the impact of obesity on brain and cognition in aging remains debatable, especially for white matter. We therefore aimed to determine the effects of obesity on white matter microstructure and potential implications for cognition in a well-characterized large cohort of healthy adults. In total, 1255 participants (50% females, 19-80 years, BMI 16.8-50.2 kg/m2) with diffusion-weighted magnetic resonance imaging at 3T were analysed. Tract-based spatial statistics (TBSS) probed whether body mass index (BMI) and waist-to-hip ratio (WHR) were related to fractional anisotropy (FA). We conducted partial correlations and mediation analyses to explore whether obesity or regional FA were related to cognitive performance. Analyses were adjusted for demographic, genetic, and obesity-associated confounders. Results showed that higher BMI and higher WHR were associated with lower FA in multiple white matter tracts (p < 0.05, FWE-corrected). Mediation analyses provided evidence for indirect negative effects of higher BMI and higher WHR on executive functions and processing speed through lower FA in fiber tracts connecting (pre)frontal, visual, and associative areas (indirect paths, |ß| ≥ 0.01; 99% |CI| > 0). This large cross-sectional study showed that obesity is correlated with lower FA in multiple white matter tracts in otherwise healthy adults, independent of confounders. Moreover, although effect sizes were small, mediation results indicated that visceral obesity was linked to poorer executive functions and lower processing speed through lower FA in callosal and associative fiber tracts. Longitudinal studies are needed to support this hypothesis.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Zhang R,Beyer F,Lampe L,Luck T,Riedel-Heller SG,Loeffler M,Schroeter ML,Stumvoll M,Villringer A,Witte AVdoi
10.1016/j.neuroimage.2018.01.028subject
Has Abstractpub_date
2018-05-15 00:00:00pages
239-249eissn
1053-8119issn
1095-9572pii
S1053-8119(18)30028-4journal_volume
172pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract::Temporal connectives (before/after) give us the freedom to describe a sequence of events in different orders. Studies have suggested that 'before-initiating' sentences, in which events are expressed in an order inconsistent with their actual order of occurrence, might need additional computation(s) during comprehensio...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.11.039
更新日期:2012-02-15 00:00:00
abstract::Neuroimaging centers and pharmaceutical companies are working together to evaluate treatments that might slow the progression of Alzheimer's disease (AD), a common but devastating late-life neuropathology. Recently, automated brain mapping methods, such as tensor-based morphometry (TBM) of structural MRI, have outperf...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.01.104
更新日期:2010-05-15 00:00:00
abstract::Relevant features in the visual image are often spatially extensive and have complex orientation structure. Our perceptual sensitivity to such spatial form is demonstrated by polar Glass patterns, in which an array of randomly-positioned dot pairs that are each aligned with a particular polar displacement (rotation, f...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2013.04.036
更新日期:2013-09-01 00:00:00
abstract::Caffeine is the most widely used stimulant in the world. The stimulant effects of caffeine are mediated through its antagonistic properties on neuronal adenosine receptors. In addition, caffeine blocks neurovascular adenosine receptors and decreases cerebral perfusion. Although the effects of caffeine on blood oxygena...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-10-01 00:00:00
abstract::Activation detection in functional Magnetic Resonance Imaging (fMRI) typically assumes the hemodynamic response to neuronal activity to be invariant across brain regions and subjects. Reports of substantial variability of the morphology of blood-oxygenation-level-dependent (BOLD) responses are accumulating, suggesting...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2014.02.018
更新日期:2014-06-01 00:00:00
abstract::Life stress has been shown to impact cognitive functions, including inhibitory control. However, the immediate effects of acute stress on inhibitory control and the underlying neural mechanisms remain unclear. In a behavioral pilot study (N = 30) and a within-subject functional magnetic resonance imaging study (N = 30...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116212
更新日期:2020-01-01 00:00:00
abstract::Echo-planar imaging (EPI) generates considerable acoustic noise by rapidly oscillating gradients. In functional magnetic resonance imaging (FMRI), unshielded EPI sounds activate the auditory system inasmuch as it is responsive. Instead of attenuating EPI noise, our goal was to utilize it for auditory FMRI by omitting ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.11.026
更新日期:2007-03-01 00:00:00
abstract::Averaged single trials (AST) allowed the functional magnetic resonance imaging (fMRI) response to auditory stimuli to be measured at high temporal (1 s) and spatial (0.1 cm3) resolution. Using this paradigm we investigated the transient signal response to 100-ms tone bursts in trains of between 100 ms and 25.5 s in to...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.1998.0322
更新日期:1998-04-01 00:00:00
abstract::Anticipatory anxiety is a complex combination of a future-oriented cognitive state, negative affect, and autonomic arousal. A dual-task paradigm of anticipation of electric shocks and a motor-learning task was used to examine the changes in neural patterns of activation associated with modulation of the cognitive stat...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章
doi:10.1006/nimg.1999.0407
更新日期:1999-06-01 00:00:00
abstract::Hippocampal atrophy and posterior cingulate hypometabolism are common features of both Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). These regions show correlated activity at rest as part of the 'default network', and they are connected by the cingulum, a white matter (WM) tract. We hypothesised that h...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.02.027
更新日期:2007-05-15 00:00:00
abstract::Proton magnetic resonance spectroscopy (1H-MRS) has provided valuable information about the neurochemical profile of Alzheimer's disease (AD). However, its clinical utility has been limited in part by the lack of consistent information on how metabolite concentrations vary in the normal aging brain and in carriers of ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2017.03.031
更新日期:2017-05-15 00:00:00
abstract::The neural bases of the different processes involved in task switching remain poorly identified. Whether distinct brain regions are involved according to the overall structure of the task sequence and the predictability of task timing during task switching is unknown. To address this question, we used functional magne...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2002.1169
更新日期:2002-09-01 00:00:00
abstract::The present review discusses a well-established method for characterizing resting-state activity of the human brain using multichannel electroencephalography (EEG). This method involves the examination of electrical microstates in the brain, which are defined as successive short time periods during which the configura...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2017.11.062
更新日期:2018-10-15 00:00:00
abstract::Small-vessel disease or cerebral microangiopathy is a common finding in elderly people leading finally to subcortical ischemic vascular dementia. Because cerebral microangiopathy impairs vascular reactivity and affects mainly the frontal lobes, we hypothesized that brain activation decreases during an event-related co...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2006.09.001
更新日期:2007-01-01 00:00:00
abstract::Humans experience a sense of self, which is proposed to emerge from the integration of intrinsic and extrinsic self-processing through the propagation of information across brain systems. Using a novel functional magnetic resonance imaging (fMRI) paradigm, we tested this hypothesis in a non-clinical sample by modulati...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2019.116284
更新日期:2020-01-15 00:00:00
abstract::Chemical exchange between water and labile protons from amino-acids, proteins and other molecules can be exploited to provide tissue contrast with magnetic resonance imaging (MRI) techniques. Using an off-resonance Spin-Locking (SL) scheme for signal preparation is advantageous because the image contrast can be tuned ...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2011.08.014
更新日期:2012-01-16 00:00:00
abstract::A new method is presented to map the orientation of intravoxel crossing fibers by using the phase of the diffusion circular spectrum harmonics. In a previous study [Zhan, W., Gu, H., Xu, S., Silbersweig, D.A., Stern, E., Yang, Y., 2003. Circular spectrum mapping for intravoxel fiber structures based on high angular re...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2004.07.062
更新日期:2004-12-01 00:00:00
abstract::Just as words can rhyme, the signs of a signed language can share structural properties, such as location. Linguistic description at this level is termed phonology. We report that a left-lateralised fronto-parietal network is engaged during phonological similarity judgements made in both English (rhyme) and British Si...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.12.047
更新日期:2008-04-15 00:00:00
abstract::The question of the self has intrigued philosophers and psychologists for a long time. More recently, distinct concepts of self have also been suggested in neuroscience. However, the exact relationship between these concepts and neural processing across different brain regions remains unclear. This article reviews neu...
journal_title:NeuroImage
pub_type: 杂志文章,meta分析
doi:10.1016/j.neuroimage.2005.12.002
更新日期:2006-05-15 00:00:00
abstract::A key challenge for cognitive neuroscience is deciphering the representational schemes of the brain. Stimulus-feature-based encoding models are becoming increasingly popular for inferring the dimensions of neural representational spaces from stimulus-feature spaces. We argue that such inferences are not always valid b...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2018.03.041
更新日期:2018-07-01 00:00:00
abstract::In recent studies it has been shown that temporal predictability of expected events alters processing in perception and action. Yet, the neural mechanism(s) by which temporal predictability biases this processing is to date little understood. Therefore, in the present fMRI study we investigated how temporal predictabi...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.10.091
更新日期:2013-02-01 00:00:00
abstract::Susceptibility-induced static field (B0) inhomogeneity near the nasal cavity degrades high-field MRI image quality. Many studies have addressed this problem by hardware- or sequence-based methods to improve local B0 shimming or minimize the impact of inhomogeneity. Here, we investigate the feasibility of the head-tilt...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2020.117265
更新日期:2020-12-01 00:00:00
abstract::Ultra High Field (UHF) MRI requires improved gradient and shim performance to fully realize the promised gains (SNR as well as spatial, spectral, diffusion resolution) that higher main magnetic fields offer. Both the more challenging UHF environment by itself, as well as the higher currents used in high performance co...
journal_title:NeuroImage
pub_type: 杂志文章,评审
doi:10.1016/j.neuroimage.2016.11.033
更新日期:2018-03-01 00:00:00
abstract::Proton density and transverse relaxation (T2)-weighted fast spin echo images are frequently acquired. T2 quantification is commonly performed by applying an exponential fit to these two images, despite recent evidence that an exponential fit is insufficient to correctly quantify T2 in the presence of imperfect RF refo...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2015.05.079
更新日期:2015-09-01 00:00:00
abstract::Spontaneous activity of the brain at rest frequently has been considered a mere backdrop to the salient activity evoked by external stimuli or tasks. However, the resting state of the brain consumes most of its energy budget, which suggests a far more important role. An intriguing hint comes from experimental observat...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2012.10.024
更新日期:2013-02-01 00:00:00
abstract::The James-Lange theory of emotion proposes that automatically generated bodily reactions not only color subjective emotional experience of stimuli, but also necessitate a mechanism by which these bodily reactions are differentially generated to reflect stimulus quality. To examine this putative mechanism, we simultane...
journal_title:NeuroImage
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2004.10.013
更新日期:2005-02-01 00:00:00
abstract::Visuomotor rotation (VMR) is a variant of the classic mental rotation paradigm. Subjects perform a center-out arm reaching movement, with the instruction to point clockwise or anticlockwise away from the direction of a reaction signal by a prespecified amount. Like classic mental rotation (MR) tasks, there is a linear...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1006/nimg.2002.1266
更新日期:2002-11-01 00:00:00
abstract::Unilateral sensory stimulation reliably elicits contralateral somatotopic activation of primary (SI) and secondary (SII) somatosensory cortex. There is an ongoing debate about the occurrence and nature of concomitant ipsilateral SI and SII activation. Here we used functional magnetic resonance imaging (fMRI) in health...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2007.05.038
更新日期:2007-09-01 00:00:00
abstract::To better understand the mechanisms by which working memory training can augment human performance we continuously monitored trainees with near infrared spectroscopy (NIRS) while they performed a dual verbal-spatial working memory task. Linear mixed effects models were used to model the changes in cerebral hemodynamic...
journal_title:NeuroImage
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuroimage.2013.05.103
更新日期:2014-01-15 00:00:00
abstract::Multiecho T(2) relaxation measurements offer specific information about myelin content through the myelin water fraction (MWF), as well as about the water environments through the intra- and extra-cellular (IE), and global, geometric mean T(2) (GMT(2)) times. While these measurements have yielded new insights into bra...
journal_title:NeuroImage
pub_type: 杂志文章
doi:10.1016/j.neuroimage.2010.08.076
更新日期:2011-01-15 00:00:00