Abstract:
PURPOSE:A recent regulatory warning and case reports have described the development of muscle complications with the use of 5-α reductase inhibitors (5ARIs). We wished to determine if there was a link between rhabdomyolysis and 5ARI usage. METHODS:We used a matched cohort design and linked administrative data from the province of Ontario, Canada, to investigate the risk of rhabdomyolysis in men using either finasteride or dutasteride. A total of 99 covariates were measured. We identified 93 197 men ≥66 years of age who initiated a new prescription for a 5ARI, and they were matched using a propensity score to an equal number of men not prescribed a 5ARI. RESULTS:New initiation of 5ARIs was not associated with a significantly increased risk of rhabdomyolysis (hazard ratio [HR] 1.21, 95% confidence interval [CI], 1.00-1.48, P = .06). When we examined the risk of rhabdomyolysis in the year prior to the initiation of a 5ARI, we found that men who would go on to use a 5ARI in the future had an elevated risk of rhabdomyolysis even prior to starting the medication (HR 1.31, 95% CI, 1.05-1.64, P = .01). Our secondary outcome of myositis and myopathy was significantly higher among 5ARI users (HR 1.63, 95% CI, 1.48-1.80, P < .01), and this risk was not present prior to 5ARI usage. CONCLUSION:5-α reductase inhibitors do not appear to be associated with the development of rhabdomyolysis; however, they may be associated with an increased risk of myopathy and myositis.
journal_name
Pharmacoepidemiol Drug Safjournal_title
Pharmacoepidemiology and drug safetyauthors
Welk B,McArthur E,Ordon M,Dirk J,Dixon S,Garg AXdoi
10.1002/pds.4383subject
Has Abstractpub_date
2018-03-01 00:00:00pages
351-355issue
3eissn
1053-8569issn
1099-1557journal_volume
27pub_type
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:2010-04-01 00:00:00
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更新日期:2018-11-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:2018-02-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
pub_type: 撤回出版物
doi:
更新日期:2013-02-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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更新日期:2008-07-01 00:00:00
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更新日期:2020-10-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:2003-04-01 00:00:00
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journal_title:Pharmacoepidemiology and drug safety
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doi:10.1002/pds.1991
更新日期:2010-09-01 00:00:00
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更新日期:2012-01-01 00:00:00