Abstract：
OBJECTIVE:To evaluate the effect of folic acid supplementation on seizure control in folate deficient children receiving long term antiepileptic therapy. METHODS:In a prospective interventional study, 140 children between age group 6 mo to 180 mo fulfilling the inclusion criteria were enrolled in study group, from October 2015 through November 2016. On the basis of serum folate, study group was divided into two subgroups by non randomization: Group A (<10 ng/ml) given folic acid supplementation for 3 mo and Group B (>10 ng/ml) was not supplemented. Response to folic acid supplementation in group A was compared with group B in terms of change in blood folate levels, frequency and duration of seizures after three months. RESULTS:Mean age of study group was 73.58 ± 46.89 mo (72.14% boys and 27.85% girls). 67.85% children were in group A and 32.14% in group B. On 3 mo follow up, children supplemented with folic acid (Group A) had significant fall in mean seizure frequency while in non-supplemented children (Group B), no significant change was seen (p value <0.05). Similar reduction in duration of seizure episode was seen in group A as compared to group B. Serum and RBC folate levels improved from baseline in group A, while in group B there was significant fall in folate levels. CONCLUSIONS:Folate deficiency is common in epileptic children on long term antiepileptic drugs (AEDs), contributes to poor seizure control and should be considered in the etiologic differentials of drug resistant epilepsy. Folate supplementation improves seizure control in these children.
journal_name
Indian J Pediatrjournal_title
Indian journal of pediatricsauthors
Deopa B,Parakh M,Dara P,Payal V,Chordiya K,Panday A,Singh S,Parashar Ddoi
10.1007/s12098-018-2608-1subject
Has Abstractpub_date
2018-07-01 00:00:00pages
493-497issue
7eissn
0019-5456issn
0973-7693pii
10.1007/s12098-018-2608-1journal_volume
85pub_type
临床试验,杂志文章abstract：OBJECTIVE:To compare oral co-amoxiclav with injectable ampicillin and amikacin for the management of asymptomatic neonates born to mothers with risk factors for infection. METHODS:This open label, randomized controlled trial was conducted in a tertiary care teaching hospital on neonates of gestational age ≥ 34 wk with...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-020-03412-x
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
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journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
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更新日期：2014-08-01 00:00:00
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journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02749728
更新日期：1989-01-01 00:00:00
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-014-1415-6
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journal_title：Indian journal of pediatrics
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
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journal_title：Indian journal of pediatrics
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更新日期：1992-03-01 00:00:00
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/s12098-011-0635-2
更新日期：2012-10-01 00:00:00
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
doi：10.1007/BF02724021
更新日期：2005-04-01 00:00:00
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
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更新日期：2008-08-01 00:00:00
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更新日期：2015-11-01 00:00:00
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Indian journal of pediatrics
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更新日期：2009-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章,meta分析,评审
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更新日期：2009-12-01 00:00:00
abstract：:HIV infection has profound effects on a patient's nutritional status because it can modulate appetite, nutrient absorption and basal metabolic rate. In addition, HIV infection can lead to the depletion of a variety of vitamins and micronutrients including vitamins A, D, B2, B6, B12, L-carnitine, iron, zinc and seleniu...
journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/BF02730805
更新日期：1996-09-01 00:00:00
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journal_title：Indian journal of pediatrics
pub_type： 杂志文章,评审
doi：10.1007/s12098-017-2535-6
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:The present study aimed at assessing the population prevalence of goiter and iodine deficiency in school children of 6-12 yr living in urban slums of Bhubaneswer, the capital city of Orissa. METHODS:A cross-sectional study was performed using the 30-cluster sampling methodology and surveillance methods for i...
journal_title：Indian journal of pediatrics
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doi：10.1007/s12098-007-0169-9
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