Abstract:
BACKGROUND:Erythropoiesis stimulating agents (ESAs) are neuroprotective in cell and animal models of preterm birth. Prematurity has been shown to alter neurometabolite levels in children in studies using proton magnetic resonance spectroscopy (1H-MRS). OBJECTIVE:We hypothesized that ESA treatment in premature infants would tend to normalize neurometabolites by 4-6 years of age. MATERIALS AND METHODS:Children in a longitudinal study of neurodevelopment underwent MRI and 1H-MRS at approximately 4 years and 6 years of age. Prematurely born children (500-1,250 g birth weight) received ESAs (erythropoietin or darbepoetin) or placebo during their neonatal hospitalization, and these groups were compared to healthy term controls. 1H-MRS spectra were obtained from the anterior cingulate (gray matter) and frontal lobe white matter, assessing combined N-acetylaspartate and N-acetylaspartylglutamate (tNAA), myo-inositol, choline compounds (Cho), combined creatine and phosphocreatine, and combined glutamate and glutamine. RESULTS:No significant (P≤0.5) group differences were observed for any metabolite level. Significant age-related increases in white-matter tNAA and Cho were observed, as well as a trend for increased gray-matter tNAA. CONCLUSION:Neither prematurity nor neonatal ESA treatment was associated with differences in brain metabolite levels in the children of this study at a significance level of 0.05. These findings suggest that earlier differences that might have existed had normalized by 4-6 years of age or were too small to be statistically significant in the current sample.
journal_name
Pediatr Radioljournal_title
Pediatric radiologyauthors
Gasparovic C,Caprihan A,Yeo RA,Phillips J,Lowe JR,Campbell R,Ohls RKdoi
10.1007/s00247-017-4052-1subject
Has Abstractpub_date
2018-03-01 00:00:00pages
374-382issue
3eissn
0301-0449issn
1432-1998pii
10.1007/s00247-017-4052-1journal_volume
48pub_type
杂志文章abstract::The relationship between image noise and radiation dose was investigated in computed tomography (CT) images of a pediatric abdomen phantom. A protocol which provided a minimum absorbed dose consistent with acceptable image noise criteria was determined for a fourth generation CT scanner. It was found that pediatric ab...
journal_title:Pediatric radiology
pub_type: 杂志文章
doi:10.1007/BF02387506
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abstract::Purpose. To determine the incidence of neurologic complications of cerebral angiography in children with moyamoya syndrome (MMS) as compared to children without MMS. Materials and methods. One-hundred-ninety consecutive cerebral angiograms obtained in 152 children were evaluated. Sixty of these angiograms were obtaine...
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journal_title:Pediatric radiology
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