Abstract:
:Dickeya zeae is the causal agent of rice foot rot disease, which has recently become a great threat to rice planting countries and regions. The pathogen produces a family of phytotoxins named zeamines that is critical for bacterial virulence, but little is known about the signaling pathways and regulatory mechanisms that govern zeamine production. In this study, we showed that a conserved transcriptional regulator Fis is involved in the regulation of zeamine production in D. zeae strain EC1. Deletion mutants were markedly attenuated in the virulence against rice seed germination. Transcriptome and phenotype analyses showed that Fis is a potent global transcriptional regulator modulating various virulence traits, including production of extracellular enzymes and exopolysaccharides, swimming and swarming motility, biofilm formation and cell aggregation. DNA gel retardation analysis showed that Fis directly regulates the transcription of key virulence genes and the genes encoding Vfm quorum sensing system through DNA/protein interaction. Our findings unveil a key regulator associated with the virulence of D. zeae EC1, and present useful clues for further elucidation of the regulatory complex and signaling pathways which govern the virulence of this important pathogen.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lv M,Chen Y,Liao L,Liang Z,Shi Z,Tang Y,Ye S,Zhou J,Zhang Ldoi
10.1038/s41598-017-18578-2subject
Has Abstractpub_date
2018-01-10 00:00:00pages
341issue
1issn
2045-2322pii
10.1038/s41598-017-18578-2journal_volume
8pub_type
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