Abstract:
:Crohn's disease is among the chronic inflammatory bowel diseases that impact the gastrointestinal tract. Understanding and predicting the severity of inflammation in real-time settings is critical to disease management. Extant literature has primarily focused on studies that are conducted in clinical trial settings to investigate the impact of a drug treatment on the remission status of the disease. This research proposes an analytics methodology where three different types of prediction models are developed to predict and to explain the severity of inflammation in patients diagnosed with Crohn's disease. The results show that machine-learning-based analytic methods such as gradient boosting machines can predict the inflammation severity with a very high accuracy (area under the curve = 92.82%), followed by regularized regression and logistic regression. According to the findings, a combination of baseline laboratory parameters, patient demographic characteristics, and disease location are among the strongest predictors of inflammation severity in Crohn's disease patients.
journal_name
Health Informatics Jjournal_title
Health informatics journalauthors
Reddy BK,Delen D,Agrawal RKdoi
10.1177/1460458217751015subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1201-1218issue
4eissn
1460-4582issn
1741-2811journal_volume
25pub_type
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