Effects of Parental Aging During Embryo Development and Adult Life: The Case of Nothobranchius furzeri.

Abstract:

:Studies on parental aging are a very attractive field, although it is poorly understood how parental age affects embryonic development and adult traits of the offspring. In this study, we used the turquoise killifish Nothobranchius furzeri, as is the vertebrate with shortest captive lifespan and an interesting model. The embryos of N. furzeri can follow two distinct developmental pathways either entering diapause or proceeding through direct development. Thus, this embryonic plasticity allows this model to be used to study different factors that could affect their embryonic development, including parental age. The first goal of the present study was to investigate whether parental aging could affect the embryo development. To do this, we collected F1 embryos from two breeder groups (old parents and young parents). We monitored the duration of embryonic development and analyzed genes involved in dorsalization process. The second goal was to investigate if embryonic developmental plasticity could be modulated by an epigenetic process. To this end, the expression of DNMTs genes was examined. Our data support the hypothesis that diapause, occurring more frequently in embryos from old parents, is associated with increased expression of DNMT3A and DNMT3B suggesting an epigenetic control. Finally, we analyzed whether parental age could affect metabolism and growth during adult life. Morphometric results and qPCR analysis of genes from IGF system showed a slower growth in adults from old breeders. Moreover, a gender-specificity effect on growth emerged. In conclusion, these results may contribute to the better understanding of the complex mechanism of aging.

journal_name

Zebrafish

journal_title

Zebrafish

authors

Api M,Biondi P,Olivotto I,Terzibasi E,Cellerino A,Carnevali O

doi

10.1089/zeb.2017.1494

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

112-123

issue

2

eissn

1545-8547

issn

1557-8542

journal_volume

15

pub_type

杂志文章
  • Zebrafish Embryo Disinfection with Povidone-Iodine: Evaluating an Alternative to Chlorine Bleach.

    abstract::Mycobacteriosis is a common bacterial infection in laboratory zebrafish caused by several different species and strains of Mycobacterium, including both rapid and slow growers. One control measure used to prevent mycobacterial spread within and between facilities is surface disinfection of eggs. Recent studies have hi...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2015.1229

    authors: Chang CT,Amack JD,Whipps CM

    更新日期:2016-07-01 00:00:00

  • Standardized Welfare Terms for the Zebrafish Community.

    abstract::Managing the welfare of laboratory animals is critical to animal health, vital in the understanding of phenotypes created by treatment or genetic alteration and ensures compliance of regulations. Part of an animal welfare assessment is the requirement to record observations, ensuring all those responsible for the anim...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2016.1248

    authors: Goodwin N,Karp NA,Blackledge S,Clark B,Keeble R,Kovacs C,Murray KN,Price M,Thompson P,Bussell J

    更新日期:2016-07-01 00:00:00

  • Low-cost aquatic lab animal holding system.

    abstract::We have constructed a low-cost aquatic animal holding system that provides an alternative to expensive, commercially available systems. Our flow-through system is especially useful for programs that are limited in space and funding. The easy assembly and maintenance of the system are advantages for the researchers who...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2006.0501

    authors: Hohn C,Petrie-Hanson L

    更新日期:2007-07-01 00:00:00

  • A primer for morpholino use in zebrafish.

    abstract::Morpholino oligonucleotides are the most common anti-sense "knockdown" technique used in zebrafish (Danio rerio). This review discusses common practices for the design, preparation, and deployment of morpholinos in this vertebrate model system. Off-targeting effects of morpholinos are discussed as well as method to mi...

    journal_title:Zebrafish

    pub_type: 杂志文章,评审

    doi:10.1089/zeb.2008.0555

    authors: Bill BR,Petzold AM,Clark KJ,Schimmenti LA,Ekker SC

    更新日期:2009-03-01 00:00:00

  • SignaFish: A Zebrafish-Specific Signaling Pathway Resource.

    abstract::Understanding living systems requires an in-depth knowledge of the signaling networks that drive cellular homeostasis, regulate intercellular communication, and contribute to cell fates during development. Several resources exist to provide high-throughput data sets or manually curated interaction information from hum...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2016.1277

    authors: Csályi K,Fazekas D,Kadlecsik T,Türei D,Gul L,Horváth B,Módos D,Demeter A,Pápai N,Lenti K,Csermely P,Vellai T,Korcsmáros T,Varga M

    更新日期:2016-12-01 00:00:00

  • Dominance hierarchies in zebrafish (Danio rerio) and their relationship with reproductive success.

    abstract::The zebrafish has considerable potential for use as a model in the study of behavior in social systems, particularly dominance hierarchies, which are widespread in nature and can affect the lifelong success of individuals. There is, however, a paucity of information relating to the characterization of social groups an...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2009.0618

    authors: Paull GC,Filby AL,Giddins HG,Coe TS,Hamilton PB,Tyler CR

    更新日期:2010-03-01 00:00:00

  • Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

    abstract::We have shown that zebrafish (Danio rerio) are an excellent model for evaluating the link between early life stage exposure to environmental chemicals and disease in adulthood and subsequent unexposed generations. Previously, we used this model to identify transgenerational effects of dioxin (2,3,7,8-tetrachlorodibenz...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2016.1275

    authors: Baker BB,Yee JS,Meyer DN,Yang D,Baker TR

    更新日期:2016-10-01 00:00:00

  • Evaluating and Optimizing Fish Health and Welfare During Experimental Procedures.

    abstract::Many facilities house fish in separate static containers post-procedure, for example, while awaiting genotyping results. This ensures fish can be easily identified, but it does not allow for provision of continuous filtered water or diet. At the Wellcome Trust Sanger Institute, concern over the housing conditions led ...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2015.1165

    authors: Goodwin N,Westall L,Karp NA,Hazlehurst D,Kovacs C,Keeble R,Thompson P,Collins R,Bussell J

    更新日期:2016-07-01 00:00:00

  • Zebrafish: modeling for herpes simplex virus infections.

    abstract::For many years, zebrafish have been the prototypical model for studies in developmental biology. In recent years, zebrafish has emerged as a powerful model system to study infectious diseases, including viral infections. Experiments conducted with herpes simplex virus type-1 in adult zebrafish or in embryo models are ...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2013.0920

    authors: Antoine TE,Jones KS,Dale RM,Shukla D,Tiwari V

    更新日期:2014-02-01 00:00:00

  • Zebrafish Social Behavior in the Wild.

    abstract::Wild zebrafish exhibit a wide range of behavior. We found abundant wild zebrafish in flowing rivers and still water, in large, tightly-knit groups of hundreds of individuals, as well as in small, loose shoals. In two still-water populations, zebrafish were quite small in body size, common, and in tight groups of up to...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2015.1159

    authors: Suriyampola PS,Shelton DS,Shukla R,Roy T,Bhat A,Martins EP

    更新日期:2016-02-01 00:00:00

  • Molecular Clock as Insight to Estimate the Evolutionary History and Times of Divergence for 10 Nominal Astyanax Species (Characiformes, Characidae): An Evolutionary Approach in Species with 2n = 36, 46, 48, and 50 Chromosomes.

    abstract::Astyanax is a genus with a wide distribution ranging from the south United States to north of Patagonia (Argentina). The available cytogenetic data on Astyanax indicate a high karyotypic diversity, with diploid number of 36-52 chromosomes, presence of B chromosomes, heterochromatin polymorphism, and variations with re...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2018.1647

    authors: Piscor D,Pozzobon APB,Fernandes CA,Centofante L,Parise-Maltempi PP

    更新日期:2019-02-01 00:00:00

  • Validation of Housekeeping Genes as Internal Controls for the Study of the Effects of Microcystin-LR in Zebrafish by Real-Time PCR.

    abstract::Microcystin-leucine arginine (MC-LR) is a natural toxin produced by cyanobacterial blooms that causes severe liver damage in fish. It is crucial to investigate if housekeeping genes are affected by MC-LR in zebrafish, to permit the adequate evaluation of gene expression by RT-qPCR. We evaluated the gene expression sta...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2018.1598

    authors: Sopezki MDS,Monserrat JM,Yunes JS,Zanette J

    更新日期:2018-10-01 00:00:00

  • Premature Termination Codon-Bearing mRNA Mediates Genetic Compensation Response.

    abstract::The genetic compensation response (GCR), triggered by deleterious mutations but not by gene knockdown, has been proposed to explain many phenotypic discrepancies between gene-knockout and gene-knockdown models. GCRs have been observed in many model organisms from mice to Arabidopsis. Although the GCR is beneficial for...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2019.1824

    authors: Ma Z,Chen J

    更新日期:2020-05-20 00:00:00

  • Don't be afraid to set up your fish facility.

    abstract::Most young researchers leaving the safe haven of postdoctoral life for the unchartered territory of a PI position are confronted with a multitude of new tasks. For those using fish as their favorite model system, this often includes the daunting task of setting up and running a fish facility. New PIs are expected to k...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2012.0768

    authors: McNabb A,Scott K,Ochsenstein Ev,Seufert K,Carl M

    更新日期:2012-09-01 00:00:00

  • A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.

    abstract::Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover ...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2016.1321

    authors: Don EK,Formella I,Badrock AP,Hall TE,Morsch M,Hortle E,Hogan A,Chow S,Gwee SS,Stoddart JJ,Nicholson G,Chung R,Cole NJ

    更新日期:2017-02-01 00:00:00

  • Chromosomal Diversification Higher Than Molecular Variation in Astyanax aff. fasciatus (Teleostei, Characidae).

    abstract::Comprising a large number of species, the genus Astyanax has been intensively studied by several approaches to elucidate its evolutionary relationships. Such studies have demonstrated that many nominal species are artificial clusters where distinct taxa are grouped under the same denomination. Astyanax aff. fasciatus ...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2016.1272

    authors: Kavalco KF,Pazza R,Brandão Kde O,Garcia C,Bertollo LA,de Almeida-Toledo LF

    更新日期:2016-08-01 00:00:00

  • Comparative Developmental Toxicity and Stress Protein Responses of Dimethyl Sulfoxide to Rare Minnow and Zebrafish Embryos/Larvae.

    abstract::Dimethyl sulfoxide (DMSO), a widely used carrier solvent, can be toxic to test organisms and has species-specific sensitivity. In this study, the developmental toxicity and stress protein responses of DMSO to rare minnow (Gobiocypris rarus) and zebrafish (Danio rerio) with two tests were compared in the early life sta...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2016.1287

    authors: Xiong X,Luo S,Wu B,Wang J

    更新日期:2017-02-01 00:00:00

  • Proteomic Profiling of Zebrafish Challenged by Spring Viremia of Carp Virus Provides Insight into Skin Antiviral Response.

    abstract::Spring viremia of carp virus (SVCV) causes the skin hemorrhagic disease in cyprinid species, but its molecular mechanism of skin immune response remains unclear at the protein level. In the present study, the differential proteomics of the zebrafish (Danio rerio) skin in response to SVCV infection were examined by iso...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2019.1843

    authors: Liu R,Hu X,Lü A,Song Y,Lian Z,Sun J,Sung YY

    更新日期:2020-04-01 00:00:00

  • Impact of Pronase, Sodium Thiosulfate, and Methylene Blue Combinations on Development and Survival of Sodium Hypochlorite Surface-Disinfected Zebrafish (Danio rerio) Embryos.

    abstract::Embryo surface disinfection is utilized in aquaculture to decrease the risk of pathogen introduction into established colonies. Zebrafish embryos are commonly disinfected with unbuffered sodium hypochlorite at 25-50 ppm for 10 min with or without concurrent treatment with chemicals, including pronase (Pron), sodium th...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2020.1917

    authors: Peneyra SM,Lerpiriyapong K,Riedel ER,Lipman NS,Lieggi C

    更新日期:2020-10-01 00:00:00

  • Production of F₁ offspring with vitrified sperm from a live-bearing fish, the green swordtail Xiphophorus hellerii.

    abstract::This study reports the first production of offspring with vitrified sperm from a live-bearing fish Xiphophorus hellerii. The overall goal of this study was to develop streamlined protocols for integration into a standardized approach for vitrification of aquatic species germplasm. The objectives were to (1) estimate a...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2011.0704

    authors: Cuevas-Uribe R,Yang H,Daly J,Savage MG,Walter RB,Tiersch TR

    更新日期:2011-12-01 00:00:00

  • Clove Oil and AQUI-S Efficacy for Zebrafish Embryo, Larva, and Adult Anesthesia.

    abstract::Since the use of the zebrafish Danio rerio genetic model organism within the scientific research community continues to grow rapidly, continued procedural refinement to support high-quality, reproducible research and improve animal welfare remains an important focus. As such, anesthesia remains one of the most frequen...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2019.1737

    authors: Ehrlich O,Karamalakis A,Krylov AJ,Dudczig S,Hassell KL,Jusuf PR

    更新日期:2019-10-01 00:00:00

  • Xiphophorus: carving a niche towards a broader understanding of aggression and dominance.

    abstract::A review of some exciting new directions for Xiphophorus research in behavioral ecology and integrative animal behavior is presented. The primary objective of this review is to identify areas of research in this teleost genus that, if studied further, could yield insights into the manifold causes and consequences of d...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2006.3.287

    authors: Earley RL

    更新日期:2006-01-01 00:00:00

  • Germplasm cryobanking in zebrafish and other aquarium model species.

    abstract::During the last few years zebrafish and other aquarium fish have become more important model system species. In zebrafish valuable biotechnological lines are constantly emerging, and the creation of cryobanks of viable fish sperm, oocytes, and embryos from those lines is a constant and important demand. Cryopreservati...

    journal_title:Zebrafish

    pub_type: 杂志文章,评审

    doi:10.1089/zeb.2009.0592

    authors: Robles V,Cabrita E,Herráez MP

    更新日期:2009-09-01 00:00:00

  • Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish.

    abstract::β-Cells of the islet of Langerhans produce insulin to maintain glucose homeostasis. Self-replication of β-cells is the predominant mode of postnatal β-cell production in mammals, with about 20% of rodent β cells dividing in a 24-hour period. However, replicating β-cells are rare in adults. Induction of self-replicatio...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2012.0816

    authors: Li M,Maddison LA,Crees Z,Chen W

    更新日期:2013-06-01 00:00:00

  • Exploring differential gene expression in zebrafish to teach basic molecular biology skills.

    abstract::In an effort to engage students in original research while teaching them basic molecular biology skills, we have designed a course for upper level undergraduate students and beginning graduate students that employs in situ hybridization in whole-mount zebrafish embryos to explore the concept of differential gene regul...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2008.0574

    authors: Schmoldt A,Forecki J,Hammond DR,Udvadia AJ

    更新日期:2009-06-01 00:00:00

  • Soybean Meal and Soy Protein Concentrate in Early Diet Elicit Different Nutritional Programming Effects on Juvenile Zebrafish.

    abstract::There is now strong evidence that early nutrition plays an important role in shaping later physiology. We assessed here whether soy protein concentrate (SPC) or soybean meal (SBM) in early diet would modify zebrafish responses to these products in later life. We fed zebrafish larvae with SPC-, SBM-, or a control-diet ...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2015.1131

    authors: Perera E,Yúfera M

    更新日期:2016-02-01 00:00:00

  • An Open-Source Husbandry Repository.

    abstract::Electronic databases provide effective and efficient management of zebrafish colony operations, but commercially available options are expensive. In this study we have developed a free zebrafish management repository alternative using free Google applications. Husbandry information is logged into a Google Sheets-based...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2018.1583

    authors: LaCoursiere CM,Ullmann JFP,Poduri A

    更新日期:2018-12-01 00:00:00

  • Computer Animation Technology in Behavioral Sciences: A Sequential, Automatic, and High-Throughput Approach to Quantifying Personality in Zebrafish (Danio rerio).

    abstract::An emergent field of animal personality necessitates a method for repeated high-throughput quantification of behavioral traits across contexts. In this study, we have developed an automated video stimulus approach to sequentially present different contexts relevant to five "personality" traits (exploration, boldness, ...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2017.1532

    authors: Fangmeier ML,Noble DWA,O'Dea RE,Usui T,Lagisz M,Hesselson D,Nakagawa S

    更新日期:2018-04-01 00:00:00

  • Intestinal Transit Time and Cortisol-Mediated Stress in Zebrafish.

    abstract::Intestinal motility, the spontaneous and rhythmic smooth muscle contraction, is a complex process that is regulated by overlapping and redundant regulatory mechanisms. Primary regulators intrinsic to the gastrointestinal tract include interstitial cells of Cajal, enteric neurons, and smooth muscle cells. Extrinsic pri...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2017.1440

    authors: Brady C,Denora M,Shannon I,Clark KJ,Rich A

    更新日期:2017-10-01 00:00:00

  • Using zebrafish to learn statistical analysis and Mendelian genetics.

    abstract::This project was developed to promote understanding of how mathematics and statistical analysis are used as tools in genetic research. It gives students the opportunity to carry out hypothesis-driven experiments in the classroom: students generate hypotheses about Mendelian and non-Mendelian inheritance patterns, gath...

    journal_title:Zebrafish

    pub_type: 杂志文章

    doi:10.1089/zeb.2010.0686

    authors: Lindemann S,Senkler J,Auchter E,Liang JO

    更新日期:2011-06-01 00:00:00