Abstract:
Purpose:We previously found that the histone methyltransferase suppressor of variegation, enhancer of zeste, trithorax and myeloid-nervy-deformed epidermal autoregulatory factor-1 domain-containing protein 3 (SMYD3) is a potential independent predictive factor or prognostic factor for overall survival in gastric cancer patients, but its roles seem to differ from those in other cancers. Therefore, in this study, the detailed functions of SMYD3 in cell proliferation and migration in gastric cancer were examined. Materials and Methods:SMYD3 was overexpressed or suppressed by transfection with an expression plasmid or siRNA, and a wound healing migration assay and Transwell assay were performed to detect the migration and invasion ability of gastric cancer cells. Additionally, an MTT assay and clonogenic assay were performed to evaluate cell proliferation, and a cell cycle analysis was performed by propidium iodide staining. Furthermore, the expression of genes implicated in the ataxia telangiectasia mutated (ATM) pathway and proteins involved in cell cycle regulation were detected by polymerase chain reaction and western blot analyses. Results:Compared with control cells, gastric cancer cells transfected with si-SMYD3 showed lower migration and invasion abilities (P<0.05), and the absence of SMYD3 halted cells in G2/M phase and activated the ATM pathway. Furthermore, the opposite patterns were observed when SMYD3 was elevated in normal gastric cells. Conclusions:To the best of our knowledge, this study provides the first evidence that the absence of SMYD3 could inhibit the migration, invasion, and proliferation of gastric cancer cells and halt cells in G2/M phase via the ATM-CHK2/p53-Cdc25C pathway. These findings indicated that SMYD3 plays crucial roles in the proliferation, migration, and invasion of gastric cancer cells and may be a useful therapeutic target in human gastric carcinomas.
journal_name
J Gastric Cancerjournal_title
Journal of gastric cancerauthors
Wang L,Wang QT,Liu YP,Dong QQ,Hu HJ,Miao Z,Li S,Liu Y,Zhou H,Zhang TC,Ma WJ,Luo XGdoi
10.5230/jgc.2017.17.e33subject
Has Abstractpub_date
2017-12-01 00:00:00pages
295-305issue
4eissn
2093-582Xissn
2093-5641journal_volume
17pub_type
杂志文章abstract:PURPOSE:Since there are no proven tumor markers that reflect the course of gastric cancer, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are commonly used alternatives. However, the degree of progression that corresponds to an increase in these markers, and the values of these markers at differe...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2014.14.2.123
更新日期:2014-06-01 00:00:00
abstract:Purpose:For unresectable or initially metastatic gastric cancer, conversion surgery (CVS), after systemic chemotherapy, has received attention as a treatment strategy. This study evaluated the prognostic value of ypTNM stage and the oncologic outcomes in patients receiving CVS. Materials and Methods:A retrospective re...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2020.20.e20
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:Recently, a nomogram predicting overall survival after gastric resection was developed and externally validated in Korea and Japan. However, this gastric cancer nomogram is derived from large-volume centers, and the applicability of the nomogram in smaller centers must be proven. The purpose of this study is to...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2017.17.e21
更新日期:2017-09-01 00:00:00
abstract:PURPOSE:The use of 18F-2-deoxy-2-fluoro-D-glucose positron emission tomography-computed tomography as a routine preoperative modality is increasing for gastric cancer despite controversy with its usefulness in preoperative staging. In this study we aimed to determine the usefulness of preoperative positron emission tom...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2012.12.3.179
更新日期:2012-09-01 00:00:00
abstract::As the incidence of early gastric cancer increases, laparoscopic surgery has become one of the treatments of choice for gastric cancer. With the increase of laparoscopic surgery, the chance of discovering aberrant anatomy during the operation also increases. We present a case of laparoscopic total gastrectomy in gastr...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2013.13.3.188
更新日期:2013-09-01 00:00:00
abstract:PURPOSE:Information regarding antimicrobial prophylaxis (AMP) for gastric cancer surgery is limited. The present study investigated the efficacy of single-dose AMP for the prevention of surgical site infection (SSI) in patients undergoing gastrectomy for gastric carcinoma. MATERIALS AND METHODS:Between 2011 and 2013, ...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2014.14.3.156
更新日期:2014-09-01 00:00:00
abstract:Purpose:Despite its clinical benefits, enhanced recovery after surgery (ERAS) is less widely implemented for gastric cancer surgery. This nationwide survey investigated the current status of the implementation of ERAS in perioperative care for gastric cancer surgery in South Korea. Materials and Methods:This survey en...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2019.19.e3
更新日期:2019-03-01 00:00:00
abstract::Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) are a group of rare tumors previously known as mixed adenoneuroendocrine carcinomas (MANECs). The neuroendocrine component is high-grade and may consist of small-cell carcinoma or large-cell neuroendocrine carcinoma. The nonneuroendocrine component may consist ...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2018.18.e16
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:In resectable gastric cancer, choice regarding the extent of resection depends on tumor size, location, and distance from resection margin. However, there remains controversy for choice of resection for tumors in the middle third of the stomach. This study investigated patients who underwent gastrectomy in orde...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2010.10.4.226
更新日期:2010-12-01 00:00:00
abstract:Purpose:Although standard radical gastrectomy is recommended after noncurative resection of endoscopic submucosal dissection (ESD) for early gastric cancer in most cases, residual tumor and lymph node metastasis have not been identified after surgery. The aim of this study is to evaluate the feasibility of sentinel nod...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2019.19.e12
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:The purpose of this study was to investigate the reliability and the clinical applicability of the adenosine-triphosphate-based chemotherapy response assay (ATP-CRA) as a method of determining in vitro chemosensitivity in patients with gastric cancer. MATERIALS AND METHODS:A total of 243 gastric cancer tissue ...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2010.10.4.155
更新日期:2010-12-01 00:00:00
abstract:Purpose:Patients with gastric cancer who receive neoadjuvant therapy are staged before treatment (cStage) and after treatment (ypStage). We aimed to compare the prognostic reliability of cStage and ypStage, alone and in combination. Materials and Methods:Data for all patients who received neoadjuvant therapy followed ...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2020.20.e41
更新日期:2020-12-01 00:00:00
abstract::[This corrects the article on p. 176 in vol. 20, PMID: 32596001.]. ...
journal_title:Journal of gastric cancer
pub_type: 已发布勘误
doi:10.5230/jgc.2020.20.e31
更新日期:2020-09-01 00:00:00
abstract:PURPOSE:The aim of the present study was to assess the association between the pre-operative plasma fibrinogen level and the adjacent organ involvement in advanced gastric cancer. MATERIALS AND METHODS:A total of 923 pre-operative plasma samples were obtained from 923 patients diagnosed clinically as having advanced g...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2012.12.2.81
更新日期:2012-06-01 00:00:00
abstract::Few surgeons have adopted pancreaticoduodenectomy (PD) for the treatment of advanced gastric cancer (AGC) invading the pancreas or duodenum because it remains controversial whether its prognostic benefits outweigh the high morbidity rates in such advanced cases. However, recent technical advances have revived diverse ...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2019.19.e24
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Before expanding our indications for laparoscopic gastrectomy to advanced gastric cancer and adopting reduced port laparoscopic gastrectomy, we analyzed and audited the outcomes of laparoscopy-assisted distal gastrectomy (LADG) for adenocarcinoma; this was done during the adoptive period at our institution thro...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2015.15.1.29
更新日期:2015-03-01 00:00:00
abstract:PURPOSE:Bone metastasis from stomach cancer occurs only rarely and it is known to have a very poor prognosis. This study examined the clinical characteristics and prognosis of patients who were diagnosed with stomach cancer and bone metastasis. MATERIALS AND METHODS:The subjects were 19 patients who were diagnosed wit...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2011.11.1.38
更新日期:2011-03-01 00:00:00
abstract::We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the s...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2014.14.1.63
更新日期:2014-03-01 00:00:00
abstract::Surgery is still considered to be the mainstay for the treatment of localized gastric cancer with negative margins (R0-resection) and an adequate lymph-node-dissection (D2-lymphadenectomy). Unfortunately, most cases of gastric cancer are only diagnosed at an advanced stage due to frequent recurrences after primary res...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2013.13.2.73
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:It is hypothesized that robotic gastrectomy may surpass laparoscopic gastrectomy after the operators acquire long-term experience and skills in the manipulation of robotic arms. This study aimed to evaluate the long-term learning curve of robotic distal gastrectomy (RDG) for gastric cancer compared with laparos...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2016.16.4.240
更新日期:2016-12-01 00:00:00
abstract::Pylorus-preserving gastrectomy (PPG) is a function-preserving surgery for the treatment of early gastric cancer (EGC), aiming to decrease the complication rate and improve postoperative quality of life. According to the Japanese gastric cancer treatment guidelines, PPG can be performed for cT1N0M0 gastric cancer locat...
journal_title:Journal of gastric cancer
pub_type: 杂志文章,评审
doi:10.5230/jgc.2016.16.2.63
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Recently, laparoscopy-assisted gastrectomy (LAG) has been widely accepted modality for early gastric cancer in Korea. The indication of LAG may be extended in an experienced institution. In our institution, the first case of laparoscopy-assisted gastrectomy (LAG) for gastric cancer was performed in May 1998. We...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2012.12.1.18
更新日期:2012-03-01 00:00:00
abstract::Surgeons occasionally encounter a patient with a gastric cancer invading an adjacent organ, such as the pancreas, liver, or transverse colon. Although there is no established guideline for treatment of invasive gastric cancer, combined resection with radical gastrectomy is conventionally performed for curative purpose...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2015.15.3.214
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:Reoperations after gastrectomy for gastric cancer are performed for many types of complications. Unexpected reoperations may cause mental, physical, and financial problems for patients. The aim of the present study was to evaluate the causes of reoperations and to develop a strategic decision-making process for...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2013.13.4.242
更新日期:2013-12-01 00:00:00
abstract::Prostate cancer is the second most common cause of cancer death in men in the United States. The most common sites of metastasis include the bone, lymph nodes, lung, liver, pleura, and adrenal glands, whereas metastatic prostate cancer involving the gastrointestinal tract has been rarely reported. A 64-year-old Africa...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2014.14.4.271
更新日期:2014-12-01 00:00:00
abstract::Inflammation can be a causative factor for carcinogenesis or can result from a consequence of cancer progression. Moreover, cancer therapeutic interventions can also induce an inflammatory response. Various inflammatory parameters are used to assess the inflammatory status during cancer treatment. It is important to s...
journal_title:Journal of gastric cancer
pub_type: 杂志文章,评审
doi:10.5230/jgc.2019.19.e29
更新日期:2019-09-01 00:00:00
abstract:Purpose:The guidelines for pathological evaluation of early gastric cancer (EGC) recommend wider section intervals for surgical specimens (5-7 mm) than those for endoscopically resected specimens (2-3 mm). Studies in surgically resected EGC specimens showed not negligible lymph node metastasis risks in EGCs meeting the...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2020.20.e14
更新日期:2020-06-01 00:00:00
abstract::Ewing's sarcoma is a neoplasm of the undifferenciated small round cells, which generally affects the bone and deep soft tissues of children and adolescents. We present a case of gastric Ewing's sarcoma; a 35-year-old female who had no symptoms. While she was at a routine medical checkup, a protruding mass in her gastr...
journal_title:Journal of gastric cancer
pub_type:
doi:10.5230/jgc.2012.12.4.258
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:Gastric cancer has a high incidence and mortality rate in Korea. Despite a growing older population and an increase in the number of older patients with gastric cancer, the older patients are not willing to undergo surgery due to their operative risks. Hence, to determine the clinical characteristics and outcom...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2011.11.4.200
更新日期:2011-12-01 00:00:00
abstract:Purpose:Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GC-ERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERA...
journal_title:Journal of gastric cancer
pub_type: 杂志文章
doi:10.5230/jgc.2018.18.e24
更新日期:2018-09-01 00:00:00