Anesthesia for Lung Transplantation in Cystic Fibrosis: Retrospective Review from the Irish National Transplantation Centre.

Abstract:

:Cystic fibrosis (CF) is an autosomal recessive disorder affecting approximately 1 in 2,500 live births worldwide, with double this estimated frequency in Ireland. CF is characterized by a genetic defect of the CF transmembrane regulator protein, causing impairment of chloride ion transportation. This has multisystem consequences, particularly in the lungs, where it results in intensely mucoid secretions, which increases susceptibility to infection. Lung transplantation is indicated in CF when there is progressive decline in a patient's functional reserve. In this report, the authors present a 6-year case review of allograft lung transplantations in 41 CF patients from the Irish National Centre for Lung Transplantation from 2010 through 2015. Preoperative risk factors for morbidity and major mortality are discussed. The authors' experience with intraoperative anesthetic challenges and management options are outlined, and postoperative complications are discussed.

authors

Lenihan M,Mullane D,Buggy D,Flood G,Griffin M

doi

10.1053/j.jvca.2017.11.041

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

2372-2380

issue

5

eissn

1053-0770

issn

1532-8422

pii

S1053-0770(17)30923-0

journal_volume

32

pub_type

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