Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1.

abstract：:The arthropod-transmitted chikungunya virus (CHIKV) causes a flu-like disease that is characterized by incapacitating arthralgia. The re-emergence of CHIKV and the continual risk of new epidemics have reignited research in CHIKV pathogenesis. Virus-specific antibodies have been shown to control virus clearance, but an...

journal_title：Scientific reports

authors： Lum FM,Couderc T,Chia BS,Ong RY,Her Z,Chow A,Leo YS,Kam YW,Rénia L,Lecuit M,Ng LFP

更新日期：2018-01-30 00:00:00

abstract：:Garcinia L. (Clusiaceae) fruits are a rich source of (-)-hydroxycitric acid, and this has gained considerable attention as an anti-obesity agent and a popular weight loss food supplement. In this study, we assessed adulteration of morphologically similar samples of Garcinia using DNA barcoding, and used NMR to quantif...

journal_title：Scientific reports

authors： Seethapathy GS,Tadesse M,Urumarudappa SKJ,V Gunaga S,Vasudeva R,Malterud KE,Shaanker RU,de Boer HJ,Ravikanth G,Wangensteen H

更新日期：2018-07-12 00:00:00

abstract：:The use of entomopathogenic fungi for biocontrol of plant pests is recently receiving an increased interest due to the need of reducing the impact of agricultural practices on the environment. Biocontrol efficacy could be improved by co-inoculation of different microorganisms. However, interactions between the fungal ...

journal_title：Scientific reports

authors： Canfora L,Abu-Samra N,Tartanus M,Łabanowska BH,Benedetti A,Pinzari F,Malusà E

更新日期：2017-10-12 00:00:00

abstract：:Streptomyces coelicolor is a Gram-positive microorganism often used as a model of physiological and morphological differentiation in streptomycetes, prolific producers of secondary metabolites with important biological activities. In the present study, we analysed Streptomyces coelicolor growth and differentiation in ...

journal_title：Scientific reports

authors： Pisciotta A,Manteca A,Alduina R

更新日期：2018-09-12 00:00:00

abstract：:While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail in approximately 25% of patients and these patients have limited treatment options. Another significant group of patients is being overtreated, which causes long-lasting side effects. Identification of molecules contro...

journal_title：Scientific reports

authors： El Zawily A,McEwen E,Toosi B,Vizeacoumar FS,Freywald T,Vizeacoumar FJ,Freywald A

更新日期：2017-11-07 00:00:00

abstract：:Theoretical model required for the evolution of regular dislocation pattern should simultaneously take into account both static distribution and dynamic evolution of dislocation pattern. In principle, there exists a stable uniformly moving dislocation with both core and far field advancing at the same constant velocit...

journal_title：Scientific reports

authors： Li P,Zhang ZF

更新日期：2017-06-22 00:00:00

abstract：:Surface incident solar radiation (Rs) of reanalysis products is widely used in ecological conservation, agricultural production, civil engineering and various solar energy applications. It is of great importance to have a good knowledge of the uncertainty of reanalysis Rs products. In this study, we evaluated the Rs e...

journal_title：Scientific reports

authors： Zhang X,Lu N,Jiang H,Yao L

更新日期：2020-02-26 00:00:00

abstract：:Boulders are ubiquitously found on the surfaces of small rocky bodies in the inner solar system and their spatial and size distributions give insight into the geological evolution and collisional history of the parent bodies. Using images acquired by the Chang'e-2 spacecraft, more than 200 boulders have been identifie...

journal_title：Scientific reports

authors： Jiang Y,Ji J,Huang J,Marchi S,Li Y,Ip WH

更新日期：2015-11-02 00:00:00

abstract：:Disseminated diseases of the central nervous system such as amyotrophic lateral sclerosis (ALS) require that therapeutic agents are delivered and distributed broadly. Intrathecal route is attractive in that respect, but to date there was no methodology available allowing for optimization of this technique to assure sa...

journal_title：Scientific reports

authors： Malysz-Cymborska I,Golubczyk D,Kalkowski L,Burczyk A,Janowski M,Holak P,Olbrych K,Sanford J,Stachowiak K,Milewska K,Gorecki P,Adamiak Z,Maksymowicz W,Walczak P

更新日期：2018-11-07 00:00:00

abstract：:Extracellular vesicles (EVs) such as exosomes and microvesicles serve as messengers of intercellular network, allowing exchange of cellular components between cells. EVs carry lipids, proteins, and RNAs derived from their producing cells, and have potential as biomarkers specific to cell types and even cellular states...

journal_title：Scientific reports

authors： Nakai W,Yoshida T,Diez D,Miyatake Y,Nishibu T,Imawaka N,Naruse K,Sadamura Y,Hanayama R

更新日期：2016-09-23 00:00:00

abstract：:Adipocytes play a central role in maintaining metabolic homeostasis in the body. Differentiation of adipocyte precursor cells requires the transcriptional activity of peroxisome proliferator-activated receptor-γ (Pparγ) and CCAAT/enhancer binding proteins (C/Ebps). Transcriptional activity is regulated by signaling mo...

journal_title：Scientific reports

authors： Cai K,El-Merahbi R,Loeffler M,Mayer AE,Sumara G

更新日期：2017-08-03 00:00:00

abstract：:Voltage-gated ether à go-go (EAG) K(+) channels are expressed in various types of cancer cells and also in the central nervous system. Aberrant overactivation of human EAG1 (hEAG1) channels is associated with cancer and neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes. Although hEAG1 channel...

journal_title：Scientific reports

authors： Han B,He K,Cai C,Tang Y,Yang L,Heinemann SH,Hoshi T,Hou S

更新日期：2016-03-23 00:00:00

abstract：:A bistable toggle switch is a paradigmatic model in the field of biology. The dynamics of the system induced by Gaussian noise has been intensively investigated, but Gaussian noise cannot incorporate large bursts typically occurring in real experiments. This paper aims to examine effects of variations from one protein...

journal_title：Scientific reports

authors： Xu Y,Li Y,Zhang H,Li X,Kurths J

更新日期：2016-08-19 00:00:00

abstract：:Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding the immune regulatory mechanisms employed by acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells upon exposure to I...

journal_title：Scientific reports

authors： Yoyen-Ermis D,Tunali G,Tavukcuoglu E,Horzum U,Ozkazanc D,Sutlu T,Buyukasik Y,Esendagli G

更新日期：2019-08-12 00:00:00

abstract：:Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to...

journal_title：Scientific reports

authors： Pengelly RJ,Alom T,Zhang Z,Hunt D,Ennis S,Collins A

更新日期：2017-10-18 00:00:00

abstract：:Acid-sensing ion channels (ASICs) belong to the degenerin/epithelial sodium channel protein family that form mechanosensitive ion channels. Evidence as to whether or not ASICs activity is directly modulated by mechanical force is lacking. Human ASICs (hASIC1V3, hASIC2a and hASIC3a) were heterologously expressed as hom...

journal_title：Scientific reports

authors： Barth D,Fronius M

更新日期：2019-05-01 00:00:00

abstract：:The exploration of intrinsically disordered proteins in isolation is a crucial step to understand their complex dynamical behavior. In particular, the emergence of partially ordered states has not been explored in depth. The experimental characterization of such partially ordered states remains elusive due to their tr...

journal_title：Scientific reports

authors： Herrera-Nieto P,Pérez A,De Fabritiis G

更新日期：2020-07-24 00:00:00

abstract：:Porphyry deposits are copper-rich orebodies formed by precipitation of metal sulphides from hydrothermal fluids released from magmatic intrusions that cooled at depth within the Earth's crust. Finding new porphyry deposits is essential because they are our largest source of copper and they also contain other strategic...

journal_title：Scientific reports

authors： Chelle-Michou C,Rottier B,Caricchi L,Simpson G

更新日期：2017-01-12 00:00:00

abstract：:A series of edge-selectively halogenated (X = Cl, Br, I) graphene nanoplatelets (XGnPs = ClGnP, BrGnP, IGnP) were prepared simply by ball-milling graphite in the presence of Cl2, Br2 and I2, respectively. High BET surface areas of 471, 579 and 662 m(2)/g were observed for ClGnP, BrGnP and IGnP, respectively, indicatin...

journal_title：Scientific reports

authors： Jeon IY,Choi HJ,Choi M,Seo JM,Jung SM,Kim MJ,Zhang S,Zhang L,Xia Z,Dai L,Park N,Baek JB

更新日期：2013-01-01 00:00:00

abstract：:The peptidoglycan of Staphylococcus aureus is highly amidated. Amidation of α-D-isoglutamic acid in position 2 of the stem peptide plays a decisive role in the polymerization of cell wall building blocks. S. aureus mutants with a reduced degree of amidation are less viable and show increased susceptibility to methicil...

journal_title：Scientific reports

authors： Nöldeke ER,Muckenfuss LM,Niemann V,Müller A,Störk E,Zocher G,Schneider T,Stehle T

更新日期：2018-08-28 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the most deadly of the gynecological cancers. New approaches and better tools for monitoring treatment efficacy and disease progression of EOC are required. In this study, metabolomics using rapid resolution liquid chromatography mass spectrometry was applied to a systematic investig...

journal_title：Scientific reports

authors： Ke C,Li A,Hou Y,Sun M,Yang K,Cheng J,Wang J,Ge T,Zhang F,Li Q,Li J,Wu Y,Lou G,Li K

更新日期：2016-03-21 00:00:00

abstract：:The circadian clock confers daily rhythmicity on many biochemical and physiological functions and its disruption is associated with increased risks of developing obesity, diabetes, heart disease and cancer. Although, there are studies on the role of Bmal1 in carcinogenesis using germline, conditional or tissue-specifi...

journal_title：Scientific reports

authors： Korkmaz T,Aygenli F,Emisoglu H,Ozcelik G,Canturk A,Yilmaz S,Ozturk N

更新日期：2018-10-30 00:00:00

abstract：:RNA-binding proteins are key regulators of post-transcriptional processes such as alternative splicing and mRNA stabilization. Rbm24 acts as a regulator of alternative splicing in heart and skeletal muscle, and is essential for sarcomere assembly. Homozygous inactivation of Rbm24 in mice disrupts cardiac development a...

journal_title：Scientific reports

authors： de Groot NE,van den Hoogenhof MMG,Najafi A,van der Made I,van der Velden J,Beqqali A,Pinto YM,Creemers EE

更新日期：2020-05-06 00:00:00

abstract：:We propose a new method to extend the path length tunability of rotary delay-lines. This method was shown to achieve a duty cycle of >80% and repetition rates of over 40 kHz. The new method relies on a new multi-segmented micro-machined mirror and serial injection of a single reflection onto separate segments of this ...

journal_title：Scientific reports

authors： Fleddermann R,Lee WM,Huang K,Campbell GT,Lam PK,Chow JH

更新日期：2017-08-24 00:00:00

abstract：:One strategy to address new potential dangers is to generate defensive responses to stimuli that remind learned threats, a phenomenon called fear generalization. During a threatening experience, the brain encodes implicit and explicit memory traces. Nevertheless, there is a lack of studies comparing implicit and expli...

journal_title：Scientific reports

authors： Manassero E,Mana L,Concina G,Renna A,Sacchetti B

更新日期：2019-09-16 00:00:00

abstract：:In this work, we demonstrate theoretically and experimentally the possibility of tuning the electromagnetic properties of metamaterials with magnetic fields by incorporating amorphous magnetic microwires. The large permeability of these wires at microwave frequencies allows tuning the resonance of the metamaterial by ...

journal_title：Scientific reports

authors： Lopez-Dominguez V,Garcia MA,Marin P,Hernando A

更新日期：2017-08-24 00:00:00

abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...

journal_title：Scientific reports

authors： Wang L,Zhuang X,Zhuang G,Jing C

更新日期：2016-12-14 00:00:00

abstract：:Colloidal crystals composed of micro- or nano- colloids have been investigated in various fields such as photonics due to their unique optical properties. Binary colloidal crystals have an outstanding potential for fine-tuning material properties by changing the components, concentration, or size of colloids. Because ...

journal_title：Scientific reports

authors： Nho HW,Yoon TH

更新日期：2017-09-29 00:00:00

abstract：:Reciprocity is frequently assumed to require complex cognitive abilities. Therefore, it has been argued that reciprocity may be restricted to animals that can meet these demands. Here, we provide evidence for the potential presence of direct reciprocity in teleost fishes. We demonstrate that in pairs of coral reef rab...

journal_title：Scientific reports

authors： Brandl SJ,Bellwood DR

更新日期：2015-09-25 00:00:00

abstract：:The synthetic Angiotensin Converting Enzyme (ACE) inhibitors have side effects and hence demands for natural ACE inhibitors have been rising. The aim of this study is to purify and introduce natural ACE inhibitors extracted from Zizyphus jujuba fruits. Proteins from Zizyphus jujuba were lysed by trypsin, papain and th...

journal_title：Scientific reports

authors： Memarpoor-Yazdi M,Zare-Zardini H,Mogharrab N,Navapour L

更新日期：2020-03-04 00:00:00