Abstract:
:Though cognitive function is proven to be an independent predictor of survival in patients with intrinsic brain tumors, cognitive functions are still rarely considered. Aim of this study was to assess neurocognitive function and to identify risk factors for neurocognitive deficits. 103 patients with primary neuroepithelial tumors who received tumor resections or biopsies were included in this prospective study. The following data was acquired: mini-mental state examination, preoperative tumor volume, WHO grade, tumor entity and location, and the Karnofsky performance status scale. Furthermore, patients participated in extensive neuropsychological testing of attentional, memory and executive functions. General factors like age, clinical status, WHO grade, tumor volume and tumor location correlated with patients' neurocognitive functions. Affection of the parietal lobe resulted in significant impairment of attention and memory functions. Frontal lobe involvement significantly affected patients' abilities in planning complex actions and novel problem solving. Patients with temporal lesions were more likely to have impaired memory and executive functions. Comparing results among neuroepithelial tumor patients enables the identification of risk factors for cognitive impairment. General parameters such as age, KPS score, tumor size, and WHO grade are apart from the respective tumor location of high importance for neurocognitive function.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Gempt J,Lange N,Bette S,Foreman SC,Cammardella JH,Albertshauser J,Gradtke C,Buchmann N,Ryang YM,Schmidt-Graf F,Meyer B,Ringel Fdoi
10.1038/s41598-017-17833-wsubject
Has Abstractpub_date
2017-12-19 00:00:00pages
17764issue
1issn
2045-2322pii
10.1038/s41598-017-17833-wjournal_volume
7pub_type
杂志文章abstract::Here, we assessed the sulfated derivative of the microbial polysaccharide gellan gum and derivatives of λ and κ-carrageenans for their ability to inhibit Plasmodium falciparum 3D7 and Dd2 growth and invasion of red blood cells in vitro. Growth inhibition was assessed by means of flow cytometry after a 96-h exposure to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04723
更新日期:2014-04-17 00:00:00
abstract::The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42503
更新日期:2017-02-13 00:00:00
abstract::Silicon nanocrystals offer huge advantages compared to other semi-conductor quantum dots as they are made from an abundant, non-toxic material and are compatible with silicon devices. Besides, among a wealth of extraordinary properties ranging from catalysis to nanomedicine, metal nanoparticles are known to increase t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02672
更新日期:2013-01-01 00:00:00
abstract::Since it has been demonstrated that spatial cognition can be affected in visually impaired children, training strategies that exploit the plasticity of the human brain should be early adopted. Here we developed and tested a new training protocol based on the reinforcement of audio-motor associations and thus supportin...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-019-39981-x
更新日期:2019-03-01 00:00:00
abstract::ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 selectively regulates ge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02137
更新日期:2013-01-01 00:00:00
abstract::Periconceptional supplementation with folic acid reduces the occurrence of neural tube defects (NTDs). The association between maternal abnormalities in homocysteine metabolism (e.g., hyperhomocysteinaemia, folate deficiency and low vitamin B12) and the risk of NTDs-affected pregnancies has been widely evaluated in re...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/srep08510
更新日期:2015-03-02 00:00:00
abstract::The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cance...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38991
更新日期:2016-12-22 00:00:00
abstract::We study heat dissipation of a multi-wall carbon nanotube (MWCNT) device fabricated from two crossed nanotubes on a SiNx substrate under the influence of a constant (DC) electric bias. By monitoring the temperature of the substrate, we observe negligible Joule heating within the nanotube lattice itself and instead hea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46944-9
更新日期:2019-07-25 00:00:00
abstract::The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilize...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61707-7
更新日期:2020-03-20 00:00:00
abstract::Bacteria belonging to the genus Acinetobacter have become of clinical importance over the last decade due to the development of a multi-resistant phenotype and their ability to survive under multiple environmental conditions. The development of these traits among Acinetobacter strains occurs frequently as a result of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26180-3
更新日期:2018-05-17 00:00:00
abstract::Skin burns due to accidental exposure to hot steam have often been reported to be more severe than the ones occurring from dry heat. While skin burns due to flames or radiant heat have been thoroughly characterized, the mechanisms leading to steam burns are not well understood and a conundrum still exists: can second ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24647-x
更新日期:2018-05-02 00:00:00
abstract::We investigate the steerability of two-qubit Bell-diagonal states under projective measurements by the steering party. In the simplest nontrivial scenario of two projective measurements, we solve this problem completely by virtue of the connection between the steering problem and the joint-measurement problem. A neces...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22025
更新日期:2016-02-25 00:00:00
abstract::Anatomically realistic organ replicas or phantoms allow for accurate studies and reproducible research. To recreate a human kidney, mimicry of the elastic properties of the human kidney is crucial. However, none of the related work addressed the design and development of a kidney phantom using only silicone as materia...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68886-3
更新日期:2020-07-16 00:00:00
abstract::Barley is a kind of cereal grass belonging to the family Poaceae. To examine viruses infecting winter barley in Korea, we carried out a comprehensive study of barley RNA viromes using next-generation sequencing (NGS). A total of 110 barley leaf samples from 17 geographical locations were collected. NGS followed by ext...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31671-4
更新日期:2018-09-05 00:00:00
abstract::Multidomain proteins account for 70% of the eukaryotic proteome. In genetic disease, multidomain proteins are often affected by numerous mutations, but the effects of these mutations on protein stability and their roles in genetic disease are not well understood. Here, we analyzed protein globular domains to understan...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39905-9
更新日期:2019-03-06 00:00:00
abstract::This study evaluated the 4-year results of 32 patients with T1N0 low-lying rectal adenocarcinoma treated solely with californium-252 (Cf-252) neutron intracavity brachytherapy (ICBT). Patients were solicited into the study from January 2008 to June 2011. All the patients had refused surgery or surgery was contraindica...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40619
更新日期:2017-01-17 00:00:00
abstract::Microbiologically Influenced Corrosion (MIC) is a serious problem in many industries because it causes huge economic losses. Due to its excellent resistance to chemical corrosion, 2707 hyper duplex stainless steel (2707 HDSS) has been used in the marine environment. However, its resistance to MIC was not experimentall...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20190
更新日期:2016-02-05 00:00:00
abstract::The prevalence of chronic kidney disease (CKD), characterized by progressive renal dysfunction with tubulointerstitial fibrosis, is increasing because of societal aging. Uremic toxins, accumulated during renal dysfunction, cause kidney damage, leading to renal deterioration. A recent metabolomic analysis revealed that...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11049-8
更新日期:2017-09-11 00:00:00
abstract::In Australia, significant shifts in species distribution have occurred with the loss of megafauna, changes in indigenous Australian fire regime and land-use changes with European settlement. The emu, one of the last megafaunal species in Australia, has likely undergone substantial distribution changes, particularly ne...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79551-0
更新日期:2021-01-13 00:00:00
abstract::Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study aimed to distinguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in combination with GNPs. DNA dam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44752
更新日期:2017-03-16 00:00:00
abstract::Despite its intrinsic advantages, translation of laser induced breakdown spectroscopy for material identification has been often impeded by the lack of robustness of developed classification models, often due to the presence of spurious correlations. While a number of classifiers exhibiting high discriminatory power h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13169
更新日期:2015-08-19 00:00:00
abstract::Synchrotron radiation microtomography (SRμCT) is a nominally non-destructive 3D imaging technique which can visualise the internal structures of whole soft tissues. As a multi-stage technique, the cumulative benefits of optimising sample preparation, scanning parameters and signal processing can improve SRμCT imaging ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30520-8
更新日期:2018-08-13 00:00:00
abstract::Antibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic or a combination of sulphadi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12866-7
更新日期:2017-10-16 00:00:00
abstract::Neural crest cells (NCC) are stem cells that generate different lineages, including neuroendocrine, melanocytic, cartilage, and bone. The differentiation potential of NCC varies according to the level from which cells emerge along the neural tube. For example, only anterior "cranial" NCC form craniofacial bone, wherea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19727
更新日期:2016-01-27 00:00:00
abstract::The presenilin 1 (PSEN1) L271V mutation causes early-onset familial Alzheimer's disease by disrupting the alternative splicing of the PSEN1 gene, producing some transcripts harboring the L271V point mutation and other transcripts lacking exon 8 (PS1(∆exon8)). We previously reported that PS1 L271V increased amyloid bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17042
更新日期:2015-11-26 00:00:00
abstract::TRAF-interacting protein with a forkhead-associated (FHA) domain (TIFA), originally identified as an adaptor protein of TRAF6, has recently been shown to be involved in innate immunity, induced by a pathogen-associated molecular pattern (PAMP). ADP-β-D-manno-heptose, a newly identified PAMP, binds to alpha-kinase 1 (A...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-61972-6
更新日期:2020-03-20 00:00:00
abstract::The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has been counted on for conserving threatened marine fish since it regulates the commercial international trade of these species. Implementation of the international treaty for Mantas included on CITES Appendix II is challengin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37567
更新日期:2016-11-23 00:00:00
abstract::Glioblastoma (GBM) is one of the deadliest human cancers. Because of the extremely unfavorable prognosis of GBM, it is important to develop more effective diagnostic and therapeutic strategies based on biologically and clinically relevant subclassification systems. Analyzing a collection of seventeen patient-derived g...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/srep21557
更新日期:2016-02-09 00:00:00
abstract::Skin allergy is a chronic condition that affects about 20% of the population of the western world. This disease is caused by small reactive compounds, haptens, able to penetrate into the epidermis and modify endogenous proteins, thereby triggering an immunogenic reaction. Phenyl isothiocyanate (PITC) and ethyl isothio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21203
更新日期:2016-02-17 00:00:00
abstract::After nearly a century of vaccination and six decades of drug therapy, tuberculosis (TB) kills more people annually than any other infectious disease. Substantial challenges to disease eradication remain among vulnerable and underserved populations. The Guarani-Kaiowá people are an indigenous population in Paraguay an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79621-3
更新日期:2021-01-13 00:00:00