Abstract：
:The present study investigated the effects of azuki bean (Vigna angularis) extract (VAE) on the progress of atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by 1-chloro-2,4-dinitrobenzene. The efficacy of VAE in NC/Nga mice was determined by measuring gross and histological skin lesions, serum IgE levels, eosinophil ratio in peripheral leucocytes, and mRNA expression levels of interleukin (IL)-4, tumour necrosis factor (TNF)-α and interferon (IFN)-γ in splenocytes. Continuous ingestion of VAE inhibited the development of the AD-like skin lesions in a dose-dependent manner. In the VAE-treated mice, the numbers of mast cells in the skin, eosinophil ratio in peripheral leucocytes, relative mRNA expression of inflammatory cytokines in the spleen, and serum IgE levels were significantly reduced. Results suggest that VAE can inhibit the development of AD-like skin lesions in NC/Nga mice by regulating immune mediators and cells, and may be an effective alternative therapy for AD.
journal_name
Food Chemjournal_title
Food chemistryauthors
Collantes TM,Rho MC,Kwon HJ,Jung BG,Alfajaro MM,Kim DS,Kim HJ,Hosmillo M,Park JG,Son KY,Park SI,Kang MI,Park SJ,Lee SW,Lee WS,Cho KOdoi
10.1016/j.foodchem.2011.11.100subject
Has Abstractpub_date
2012-06-01 00:00:00pages
1269-1275issue
3eissn
0308-8146issn
1873-7072pii
S0308-8146(11)01684-0journal_volume
132pub_type
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