Catching DNA with hoops-biophysical approaches to clarify the mechanism of SMC proteins.

Abstract:

:Structural maintenance of chromosome (SMC) complexes are central regulators of chromosome architecture that are essential in all domains of life. For decades, the structural biology field has been debating how these conserved protein complexes use their intricate ring-like structures to structurally organize DNA. Here, we review the contributions of single-molecule biophysical approaches to resolving the molecular mechanism of SMC protein function.

journal_name

Nat Struct Mol Biol

authors

Eeftens J,Dekker C

doi

10.1038/nsmb.3507

subject

Has Abstract

pub_date

2017-12-07 00:00:00

pages

1012-1020

issue

12

eissn

1545-9993

issn

1545-9985

pii

nsmb.3507

journal_volume

24

pub_type

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