Effect of doxycycline-treated hydroxyapatite surface on bone apposition: A histomophometric study in murine maxillae.

Abstract:

:Improved osseointegration of dental implants is imperative in clinic. Effect of doxycycline on promoting bone formation after implant placement was expected due to its inhibitory properties on inflammation and osteoclastogenesis. To evaluate new bone formation on the hydroxyapatite (HA)-coated implant surface, which was treated with doxycycline, in comparison with the untreated HA surface, half of the HA-coated implants were soaked in doxycycline solution (DOX group) whereas the other HA-coated implants were untreated (HA group). Eight weeks after extracting the maxillary first molars of 4-week-old male mice, the implants of both groups were placed at the extracted site. 4 and 8 weeks after surgery, the samples were evaluated radiologically and histomorphometrically. Bone-implant contact of DOX group was statistically higher than the one of HA group at 4 and 8 weeks. New bone area between the threads of the implants also statistically increased at 8 weeks in DOX group compared to HA group.

journal_name

Dent Mater J

journal_title

Dental materials journal

authors

Ding L,Zhang P,Wang X,Hao J,Aoki K,Kuroda S,Kasugai S

doi

10.4012/dmj.2017-007

subject

Has Abstract

pub_date

2018-01-30 00:00:00

pages

130-138

issue

1

eissn

0287-4547

issn

1881-1361

journal_volume

37

pub_type

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