Abstract：
:Nuclear receptor corepressor 1 (NCOR1) is a transcriptional regulator bridging repressive chromatin modifying enzymes with transcription factors. NCOR1 regulates many biological processes, however its role in T cells is not known. Here we show that Cd4-Cre-mediated deletion of NCOR1 (NCOR1 cKOCd4) resulted in a reduction of peripheral T cell numbers due to a decrease in single-positive (SP) thymocytes. In contrast, double-positive (DP) thymocyte numbers were not affected in the absence of NCOR1. The reduction in SP cells was due to diminished survival of NCOR1-null postselection TCRβhiCD69+ and mature TCRβhiCD69- thymocytes. NCOR1-null thymocytes expressed elevated levels of the pro-apoptotic factor BIM and showed a higher fraction of cleaved caspase 3-positive cells upon TCR stimulation ex vivo. However, staphylococcal enterotoxin B (SEB)-mediated deletion of Vβ8+ CD4SP thymocytes was normal, suggesting that negative selection is not altered in the absence of NCOR1. Finally, transgenic expression of the pro-survival protein BCL2 restored the population of CD69+ thymocytes in NCOR1 cKOCd4 mice to a similar percentage as observed in WT mice. Together, these data identify NCOR1 as a crucial regulator of the survival of SP thymocytes and revealed that NCOR1 is essential for the proper generation of the peripheral T cell pool.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Müller L,Hainberger D,Stolz V,Hamminger P,Hassan H,Preglej T,Boucheron N,Sakaguchi S,Wiegers GJ,Villunger A,Auwerx J,Ellmeier Wdoi
10.1038/s41598-017-15918-0subject
Has Abstractpub_date
2017-11-21 00:00:00pages
15928issue
1issn
2045-2322pii
10.1038/s41598-017-15918-0journal_volume
7pub_type
杂志文章abstract：:Urinary biomarkers augment the diagnosis of acute kidney injury (AKI), with AKI after cardiovascular surgeries being a prototype of prognosis scenario. Glutathione S-transferases (GST) were evaluated as biomarkers of AKI. Urine samples were collected in 141 cardiovascular surgical patients and analyzed for urinary alp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26335
更新日期：2016-08-16 00:00:00
abstract：:Glutamine metabolism and the mechanistic target of rapamycin (mTOR) pathway are activated cooperatively in the differentiation and activation of inflammatory immune cells. But the combined inhibition of both pathways was rarely investigated. This study investigated how inhibiting both glutamine metabolism with 6-diazo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42932-1
更新日期：2019-04-23 00:00:00
abstract：:Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction. We recently developed an innovative experimental model of indivi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21205
更新日期：2016-02-15 00:00:00
abstract：:The empirical research on the public goods game (PGG) indicates that both institutional rewards and institutional punishment can curb free-riding and that the punishment effect is stronger than the reward effect. Self-regarding models that are based on Nash equilibrium (NE) strategies or evolutionary game dynamics cor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28809
更新日期：2016-06-24 00:00:00
abstract：:In response to environmental and nutrient stress, adipose tissues must establish a new homeostatic state. Here we show that cold exposure of obese mice triggers an adaptive tissue remodeling in visceral adipose tissue (VAT) that involves extracellular matrix deposition, angiogenesis, sympathetic innervation, and adipo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45354-1
更新日期：2019-06-20 00:00:00
abstract：:During ice-free periods, the Northern Sea Route (NSR) could be an attractive shipping route. The decline in Arctic sea-ice extent, however, could be associated with an increase in the frequency of the causes of severe weather phenomena, and high wind-driven waves and the advection of sea ice could make ship navigation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16868
更新日期：2015-11-20 00:00:00
abstract：:Erythropoiesis is regulated by the erythropoietin receptor (EpoR) binding to its ligand. The transmembrane domain (TMD) and the juxtamembrane (JM) regions of the EpoR are important for signal transduction across the cell membrane. We report a solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13586
更新日期：2015-08-28 00:00:00
abstract：:Increased evidence suggests that dysregulation of cholesterol metabolism may be a key event contributing to progression of multiple sclerosis (MS). Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maint...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02638-8
更新日期：2017-06-02 00:00:00
abstract：:The trace addition of rare earth (RE) elements in Mg alloys can modify the extrusion texture, leading to the formation of RE texture and thus improved formability. The interrupted extrusion experiment as well as electron back-scatter diffraction (EBSD) characterization was conducted in Mg-1.5Zn-0.5Gd (wt.%) alloy to u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35170-4
更新日期：2018-11-14 00:00:00
abstract：:The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited numerous investigations on the possibility of vaccine-associated enhanced disease, but the potential mechanisms remain largely unresolved. Here, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37341
更新日期：2016-11-16 00:00:00
abstract：:Understanding coupling of ferroic properties over grain boundaries and within clusters of grains in polycrystalline materials is hindered due to a lack of direct experimental methods to probe the behaviour of individual grains in the bulk of a material. Here, a variant of three-dimensional X-ray diffraction (3D-XRD) i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22820
更新日期：2016-03-09 00:00:00
abstract：:Free-ocean CO2 enrichment (FOCE) experiments have been deployed in marine ecosystems to manipulate carbonate system conditions to those predicted in future oceans. We investigated whether the pH/carbonate chemistry of extremely cold polar waters can be manipulated in an ecologically relevant way, to represent conditio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21029-1
更新日期：2018-02-12 00:00:00
abstract：:Production of reactive nitrogen species (NO) is a key step in the immune response following infections. NO induces lesions to bacterial DNA, thus limiting bacterial growth within hosts. Using two pathogenic bacteria, Bacillus cereus and Shigella flexneri, we show that the DNA-repair protein Mfd (Mutation-Frequency-Dec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29349
更新日期：2016-07-20 00:00:00
abstract：:The concept of substrate inhibition to prevent its phosphorylation has potential in drug discovery and is envisioned to treat the autoimmune disorder multiple sclerosis (MS). Glia maturation factor-β (GMF-β) Ser83 phosphorylation by protein kinase A (PKA) is pivotal in the activation of GMF-β-p38MAPK-NFκB biochemical ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60710-2
更新日期：2020-03-02 00:00:00
abstract：:Development of novel anti-influenza A virus (IAV) drugs with high efficiency and low toxicity is critical for preparedness against influenza outbreaks. Herein, we investigated the anti-IAV activities and mechanisms of fucoidan in vitro and in vivo. The results showed that a fucoidan KW derived from brown algae Kjellma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40760
更新日期：2017-01-17 00:00:00
abstract：:Bisphenol A (BPA), a member of the environmental endocrine disruptors (EDCs), has recently received increased attention because of its effects on brain insulin resistance. Available data have indicated that brain insulin resistance may contribute to neurodegenerative diseases. However, the associated mechanisms that u...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07544-7
更新日期：2017-08-08 00:00:00
abstract：:Effective quality assurance is essential in any screening programme. This article provides a unique insight into key quality indicators of five rounds of the first population-based colorectal cancer screening programme implemented in Spain (2000-2012), providing the results according to the type of screening (prevalen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19532
更新日期：2016-01-20 00:00:00
abstract：:The epigenetic status of the genome changes dynamically from fertilization to implantation. In addition, the physiological environment during the process of gametogenesis, including parental age, may affect the epigenome of the embryo after fertilization. It is important to clarify the influence of parental age on gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20614-8
更新日期：2018-02-05 00:00:00
abstract：:The major components of vitelline membrane (VM) are ovomucin, VM outer (VMO) I and VMO II. At present, the distribution pattern of maternal cells on the VM has not been described in detail. In this study, the existence and distribution characteristics of maternal cells on VM were observed. There were more than 3.2 × 1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06996-1
更新日期：2017-07-26 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60584-4
更新日期：2020-02-27 00:00:00
abstract：:Biocontrol offers a promising alternative to synthetic fungicides for the control of a variety of pre- and post-harvest diseases of crops. Black rot, which is caused by the pathogenic fungus Ceratocytis fimbriata, is the most destructive post-harvest disease of sweet potato, but little is currently known about potenti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52804-3
更新日期：2019-11-08 00:00:00
abstract：:Regime shift from grasslands to shrub-dominated landscapes occur worldwide driven by altered land-use and climate change, affecting landscape function, biodiversity, and productivity. Warming winter temperatures are a main driver of expansion of the native, evergreen shrub, Morella cerifera, in coastal landscapes. Shr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65161-3
更新日期：2020-05-19 00:00:00
abstract：:Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19691-6
更新日期：2018-01-19 00:00:00
abstract：:The therapeutic potential of targeting CD4+Foxp3+ regulatory T cells (Tregs) remains controversial under the condition of neuroinflammation. This study aims to explore the neuroprotective role of Tregs in optic nerve ischemia (ONI) and evaluate the therapeutic strategy of Tregs transfer with a focus on targeting the m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37805
更新日期：2016-11-25 00:00:00
abstract：:Natural infection with measles virus (MV) establishes lifelong immunity. Persistent infection with MV is likely involved in this phenomenon, as non-replicating protein antigens never induce such long-term immunity. Although MV establishes stable persistent infection in vitro and possibly in vivo, the mechanism by whic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37163
更新日期：2016-11-24 00:00:00
abstract：:Recent whooping cough (pertussis) outbreaks in many countries highlight the crucial need for a better understanding of the pathogenesis of Bordetella pertussis infection of the respiratory tract. The baboon is a recently described preclinical model for the study of B. pertussis infection and may be ideal for the evalu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30896-7
更新日期：2018-08-16 00:00:00
abstract：:Toughening of Fe-based amorphous coatings meanwhile maintaining a good corrosion resistance remains challenging. This work reports a novel approach to improve the toughness of a FeCrMoCBY amorphous coating through in-situ formation of amorphous carbon reinforcement without reducing the corrosion resistance. The Fe-bas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04504-z
更新日期：2017-06-22 00:00:00
abstract：:Prion-like behaviour is attracting much attention due to the growing evidences that amyloid-like self-assembly may reach beyond neurodegeneration and be a conserved functional mechanism. The best characterized functional prions correspond to a subset of yeast proteins involved in translation or transcription. Their co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09714-z
更新日期：2017-09-21 00:00:00
abstract：:The development of novel small molecule inhibitors of the cancer-associated tropomyosin 3.1 (Tpm3.1) provides the ability to examine the metabolic function of specific actin filament populations. We have determined the ability of these anti-Tpm (ATM) compounds to regulate glucose metabolism in mice. Acute treatment (1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22946-x
更新日期：2018-03-15 00:00:00
abstract：:Climate indices based on sea surface temperature (SST) can synthesize information related to physical processes that describe change and variability in continental precipitation from floods to droughts. The South Atlantic Subtropical Dipole index (SASD) is based on the distribution of SST in the South Atlantic and fit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05291
更新日期：2014-06-13 00:00:00
