FSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer.

abstract：:Traumatic brain injury (TBI) is a frequent cause of chronic headache, fatigue, insomnia, hyperactivity, memory deficits, irritability and posttraumatic stress disorder. Recent evidence suggests beneficial effects of pro-cannabinoid treatments. We assessed in mice levels of endocannabinoids in association with the occu...

journal_title：Scientific reports

authors： Vogel A,Wilken-Schmitz A,Hummel R,Lang M,Gurke R,Schreiber Y,Schäfer MKE,Tegeder I

更新日期：2020-09-10 00:00:00

abstract：:Amphibian oocytes have been extensively used for heterologous expression of membrane proteins for studying their biochemical and biophysical properties. So far, Xenopus laevis is the main amphibian used as oocytes source to express aquaglyceroporins in order to assess water and solutes permeability. However, this well...

journal_title：Scientific reports

authors： Rojas V,Ortiz YY,Rodríguez S,Araque V,Rodríguez-Acosta A,Figarella K,Uzcátegui NL

更新日期：2019-01-10 00:00:00

abstract：:Enterococcus faecalis, an organism generally not pathogenic for healthy humans, has the potential to cause disease in susceptible hosts. While it seems to be equipped to interact with and circumvent host immune defense, most of the molecular and cellular mechanisms underlying the enterococcal infectious process remain...

journal_title：Scientific reports

authors： Nunez N,Derré-Bobillot A,Gaubert S,Herry JM,Deschamps J,Wei Y,Baranek T,Si-Tahar M,Briandet R,Serror P,Archambaud C

更新日期：2018-01-29 00:00:00

abstract：:Attaching Unique Molecular Identifiers (UMI) to RNA molecules in the first step of sequencing library preparation establishes a distinct identity for each input molecule. This makes it possible to eliminate the effects of PCR amplification bias, which is particularly important where many PCR cycles are required, for e...

journal_title：Scientific reports

authors： Sena JA,Galotto G,Devitt NP,Connick MC,Jacobi JL,Umale PE,Vidali L,Bell CJ

更新日期：2018-09-03 00:00:00

abstract：:Using high resolution powder x-ray and neutron diffraction experiments, we determined the off-centered displacement of the ions within a unit cell and magnetoelectric coupling in nanoscale BiFeO3 (≈20-200 nm). We found that both the off-centered displacement of the ions and magnetoelectric coupling exhibit nonmonotoni...

journal_title：Scientific reports

authors： Goswami S,Bhattacharya D,Ghosh CK,Ghosh B,Kaushik SD,Siruguri V,Krishna PSR

更新日期：2018-02-27 00:00:00

abstract：:The vascular smooth muscle cells (VSMCs) are exposed to interstitial flow induced shear stress that may be sensed by the surface glycocalyx, a surface layer composed primarily of proteoglycans and glycoproteins, to mediate cell contraction during the myogenic response. We, therefore, attempted to elucidate the signal ...

journal_title：Scientific reports

authors： Kang H,Liu J,Sun A,Liu X,Fan Y,Deng X

更新日期：2017-02-13 00:00:00

abstract：:Electrolyte concentration in sweat depends on environmental context and physical condition but also on the pathophysiological status. Sweat analyzers may be therefore the future way for biological survey although how sweat electrolyte composition can reflect plasma composition remains unclear. We recruited 10 healthy ...

journal_title：Scientific reports

authors： Vairo D,Bruzzese L,Marlinge M,Fuster L,Adjriou N,Kipson N,Brunet P,Cautela J,Jammes Y,Mottola G,Burtey S,Ruf J,Guieu R,Fenouillet E

更新日期：2017-09-18 00:00:00

abstract：:Highly omnidirectional and frequency controllable carbon/polyaniline (C/PANI)-based, two- (2D) and three-dimensional (3D) monopole antennas were fabricated using screen-printing and a one-step, dimensionally confined hydrothermal strategy, respectively. Solvated C/PANI was synthesized by low-temperature interfacial po...

journal_title：Scientific reports

authors： Shin KY,Kim M,Lee JS,Jang J

更新日期：2015-09-04 00:00:00

abstract：:Restenosis remains a significant problem after angioplasty of hemodialysis vascular access. Both experimental and clinical studies have shown a protective effect of antioxidants against post-angioplasty restenosis. A prospective, randomized, feasibility study was conducted to investigate the effect of ascorbic acid to...

journal_title：Scientific reports

authors： Yang CW,Wu CC,Luo CM,Chuang SY,Chen CH,Shen YF,Tarng DC

更新日期：2019-07-31 00:00:00

abstract：:A wide range of human diseases is associated with mutations that, destabilizing proteins native state, promote their aggregation. However, the mechanisms leading from folded to aggregated states are still incompletely understood. To investigate these mechanisms, we used a combination of NMR spectroscopy and molecular ...

journal_title：Scientific reports

authors： Camilloni C,Sala BM,Sormanni P,Porcari R,Corazza A,De Rosa M,Zanini S,Barbiroli A,Esposito G,Bolognesi M,Bellotti V,Vendruscolo M,Ricagno S

更新日期：2016-05-06 00:00:00

abstract：:WD40 proteins belong to a big protein family with members identified in every eukaryotic proteome. However, WD40 proteins were only reported in a few prokaryotic proteomes. Using WDSP ( http://wu.scbb.pkusz.edu.cn/wdsp/ ), a prediction tool, we identified thousands of prokaryotic WD40 proteins, among which few protein...

journal_title：Scientific reports

authors： Shen C,Du Y,Qiao F,Kong T,Yuan L,Zhang D,Wu X,Li D,Wu YD

更新日期：2018-08-28 00:00:00

abstract：:Ginseng rusty root (GRR) symptom is one of the primary diseases of ginseng. There has been a problem of ginseng rusty root, leading to a severe decline in the quality of ginseng. To clarify the relationship between root symptoms of ginseng rust and soil, the physical and chemical properties, enzyme activity, community...

journal_title：Scientific reports

authors： Bian X,Xiao S,Zhao Y,Xu Y,Yang H,Zhang L

更新日期：2020-09-25 00:00:00

abstract：:Powdered activated carbon (AC) is commonly used as an effective additive to enhance anaerobic digestion (AD), but little is known about how the metabolic pathways resulting from adding AC change the microbial association network and enhance food waste treatment. In this work, the use of AC in an anaerobic digestion sy...

journal_title：Scientific reports

authors： Zhang J,Mao L,Zhang L,Loh KC,Dai Y,Tong YW

更新日期：2017-09-12 00:00:00

abstract：:The physiological roles of the protease inhibitor SERPINB3 (SB3) are still largely unknown. The study was addressed to assess the biological effects of this serpin in vivo using a SB3 transgenic mouse model. Two colonies of mice (123 transgenic for SB3 and 148 C57BL/6J controls) have been studied. Transgenic (TG) mice...

journal_title：Scientific reports

authors： Villano G,Ruvoletto M,Ceolotto G,Quarta S,Calabrese F,Turato C,Tono N,Crescenzi M,Biasiolo A,Cattelan A,Merkel C,Avogaro A,Gatta A,Pontisso P

更新日期：2013-10-28 00:00:00

abstract：:Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus Aspergillus oryzae, we visualized these organelles via the Rab5 homol...

journal_title：Scientific reports

authors： Togo Y,Higuchi Y,Katakura Y,Takegawa K

更新日期：2017-11-17 00:00:00

abstract：:Ocular antigens are sequestered behind the blood-retina barrier and the ocular environment protects ocular tissues from autoimmune attack. The signals required to activate autoreactive T cells and allow them to cause disease in the eye remain in part unclear. In particular, the consequences of peripheral presentation ...

journal_title：Scientific reports

authors： Voigt V,Wikstrom ME,Kezic JM,Schuster IS,Fleming P,Makinen K,Daley SR,Andoniou CE,Degli-Esposti MA,Forrester JV

更新日期：2017-10-27 00:00:00

abstract：:The identification of enhancer-target gene (ETG) pairs is vital for the understanding of gene transcriptional regulation. Experimental approaches such as Hi-C have generated valuable resources of ETG pairs. Several computational methods have also been developed to successfully predict ETG interactions. Despite these p...

journal_title：Scientific reports

authors： Zhao C,Li X,Hu H

更新日期：2016-07-20 00:00:00

abstract：:Ataxia-telangiectasia (AT) and related disorders feature cancer predisposition, neurodegeneration, and immunodeficiency resulting from failure to respond to DNA damage. Hypomorphic mutations in MRE11 cause an AT-like disorder (ATLD) with variable clinical presentation. We have sought to understand how diverse MRE11 mu...

journal_title：Scientific reports

authors： Hartlerode AJ,Regal JA,Ferguson DO

更新日期：2018-07-04 00:00:00

abstract：:Deficiency of laminin α2 chain leads to a severe form of congenital muscular dystrophy (LAMA2-CMD), and dystrophic symptoms progress rapidly in early childhood. Currently, there is no treatment for this detrimental disorder. Development of therapies is largely hindered by lack of understanding of mechanisms involved i...

journal_title：Scientific reports

authors： Gawlik KI,Körner Z,Oliveira BM,Durbeej M

更新日期：2019-10-04 00:00:00

abstract：:A simple, environmentally friendly and cost-effective nonsurfactant template method was used to synthesize tannic-acid-templated mesoporous silica nanoparticles (TMSNs), and then dopamine functionalized TMSNs (Dop-TMSNs) which was synthesized by a facile and biomimetic coating strategy, was developed as a new sorbent ...

journal_title：Scientific reports

authors： Gao J,Lei H,Han Z,Shi Q,Chen Y,Jiang Y

更新日期：2017-03-22 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Dainese E,Oddi S,Simonetti M,Sabatucci A,Angelucci CB,Ballone A,Dufrusine B,Fezza F,De Fabritiis G,Maccarrone M

更新日期：2020-03-31 00:00:00

abstract：:Phytoplankton play key roles in the oceans by regulating global biogeochemical cycles and production in marine food webs. Global warming is thought to affect phytoplankton production both directly, by impacting their photosynthetic metabolism, and indirectly by modifying the physical environment in which they grow. In...

journal_title：Scientific reports

authors： D'Alelio D,Rampone S,Cusano LM,Morfino V,Russo L,Sanseverino N,Cloern JE,Lomas MW

更新日期：2020-02-25 00:00:00

abstract：:Part of the symptomatology of post-traumatic stress disorder (PTSD) are alterations in arousal and reactivity which could be related to a maladaptive increase in the automated sensory change detection system of the brain. In the current EEG study we investigated whether the brain's response to a simple auditory sensor...

journal_title：Scientific reports

authors： Bangel KA,van Buschbach S,Smit DJA,Mazaheri A,Olff M

更新日期：2017-11-29 00:00:00

abstract：:A new bicentennial series of the Australian monsoon strength based on historical wind observations has allowed for the assessment of the variability of this system since the early 19th century. Our series covers a period in which the scarcity of meteorological observations in the area had precluded the evaluation of l...

journal_title：Scientific reports

authors： Gallego D,García-Herrera R,Peña-Ortiz C,Ribera P

更新日期：2017-11-23 00:00:00

abstract：:Platinum resistance is one of the most challenging problems in ovarian cancer treatment. High-throughput functional siRNA screening identified tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE-1) as a gene that confers cells resistant to cisplatin. Conversely enforced over-expression of TIE-1 was va...

journal_title：Scientific reports

authors： Ishibashi M,Toyoshima M,Zhang X,Hasegawa-Minato J,Shigeta S,Usui T,Kemp CJ,Grandori C,Kitatani K,Yaegashi N

更新日期：2018-09-04 00:00:00

abstract：:Simulation models in respiratory research are increasingly used for medical product development and testing, especially because in-vivo models are coupled with a high degree of complexity and ethical concerns. This work introduces a respiratory simulation system, which is bridging the gap between the complex, real ana...

journal_title：Scientific reports

authors： Pasteka R,Forjan M,Sauermann S,Drauschke A

更新日期：2019-12-24 00:00:00

abstract：:ZnO/SiC heterojunctions show great potential for various optoelectronic applications (e.g., ultraviolet light emitting diodes, photodetectors, and solar cells). However, the lack of a detailed understanding of the ZnO/SiC interface prevents an efficient and rapid optimization of these devices. Here, intrinsic (but inh...

journal_title：Scientific reports

authors： Zhang Y,Lin N,Li Y,Wang X,Wang H,Kang J,Wilks R,Bär M,Mu R

更新日期：2016-03-15 00:00:00

abstract：:The potential angiogenic effect of roxarsone, a feed additive widely used to promote animal growth worldwide, was demonstrated recently. We explored the mechanism of vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in roxarsone promotion of rat vascular endothelial cells (ECs) and B16F10 mouse xenogr...

journal_title：Scientific reports

authors： Chen S,Xu J,Wei Q,Zhao Z,Chen X,Cui H,Zhang Y

更新日期：2019-11-22 00:00:00

abstract：:Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, we demonstrate that ...

journal_title：Scientific reports

authors： Yamaki T,Suenaga Y,Iuchi T,Alagu J,Takatori A,Itami M,Araki A,Ohira M,Inoue M,Kageyama H,Yokoi S,Saeki N,Nakagawara A

更新日期：2013-01-01 00:00:00

abstract：:The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the hippocampus and normal behavior in the open-field and fear condit...

journal_title：Scientific reports

authors： Hoang Trung H,Yoshihara T,Nakao A,Hayashida K,Hirata Y,Shirasuna K,Kuwamura M,Nakagawa Y,Kaneko T,Mori Y,Asano M,Kuramoto T

更新日期：2021-01-21 00:00:00