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Magnetic resonance imaging of intracranial atherosclerosis: Comparison of ex vivo 3T MRI and histologic findings.

Abstract：

PURPOSE:Imaging the lipid-rich necrotic core (LRNC) is very important when evaluating the response of lipid-lowering therapy. The purpose of this study was to assess ex vivo LRNC of intracranial atherosclerosis using 3T MRI. MATERIALS AND METHODS:Thirty-one atherosclerotic lesions from 17 specimens were analyzed (basilar artery=15, middle cerebral artery=16) using 3T MRI. Specimens were not chemically processed for imaging studies. Reconstructed MRI was matched with histologic sections at corresponding locations. RESULTS:The median plaque thickness of intracranial atherosclerosis was 0.6mm (0.4-2.0mm). All specimens had a LRNC on histologic findings. Three specimens had plaque calcification on histologic findings. LRNC of 30 specimens (96.8%) appeared as homogeneous isointensity/hypointensity on T1-weighted imaging and hypointensity on T2-weighted imaging compared with T1-weighted imaging. CONCLUSIONS:All specimens with ex vivo intracranial atherosclerosis had LRNC. Intracranial atherosclerosis could be an indication for lipid-lowering therapy, similar to previous carotid MR studies.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Chung GH,Kwak HS,Hwang SB,Noh SJ

doi

10.1016/j.ejrad.2017.10.013

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

110-114

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(17)30406-0

journal_volume

97

pub_type

杂志文章

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