Abstract:
RATIONALE:Pegaspargase has been used in the treatment of acute lymphoblastic leukemia with promising results. However, it has also been associated with several potentially serious complications, including thrombosis. Pegaspargase-induced cerebral venous thrombosis and bone marrow necrosis are very rare. PATIENT CONCERNS:A 50-year-old female developed headache, weakness of the right lower extremity, fever, and bone pain after chemotherapy including pegaspargase for the treatment of acute lymphoblastic leukemia. DIAGNOSES:Her imaging studies and bone marrow examinations were compatible with cerebral venous thrombosis and bone marrow necrosis. INTERVENTIONS:The patient received anticoagulation therapy with rivaroxaban. OUTCOMES:After treatment with rivaroxaban, she had a good outcome without major or minor bleeding. LESSONS:Clinicians should be aware of the very rare but possible induction of bone marrow necrosis during pegaspargase treatment when there is necrosis in other organs. Because of its greater safety and convenience, rivaroxaban gains popularity over traditional anticoagulant drugs.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Sui J,Zhang Y,Yang L,Wang H,Xu J,Wei R,Hao Y,Wang X,Peng J,Ma Jdoi
10.1097/MD.0000000000008715subject
Has Abstractpub_date
2017-11-01 00:00:00pages
e8715issue
46eissn
0025-7974issn
1536-5964pii
00005792-201711170-00074journal_volume
96pub_type
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