Abstract:
:Bacteria adapt to changes in their environment via differential gene expression mediated by DNA binding transcriptional regulators. The PRODORIC2 database hosts one of the largest collections of DNA binding sites for prokaryotic transcription factors. It is the result of the thoroughly redesigned PRODORIC database. PRODORIC2 is more intuitive and user-friendly. Besides significant technical improvements, the new update offers more than 1000 new transcription factor binding sites and 110 new position weight matrices for genome-wide pattern searches with the Virtual Footprint tool. Moreover, binding sites deduced from high-throughput experiments were included. Data for 6 new bacterial species including bacteria of the Rhodobacteraceae family were added. Finally, a comprehensive collection of sigma- and transcription factor data for the nosocomial pathogen Clostridium difficile is now part of the database. PRODORIC2 is publicly available at http://www.prodoric2.de.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Eckweiler D,Dudek CA,Hartlich J,Brötje D,Jahn Ddoi
10.1093/nar/gkx1091subject
Has Abstractpub_date
2018-01-04 00:00:00pages
D320-D326issue
D1eissn
0305-1048issn
1362-4962pii
4607805journal_volume
46pub_type
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