Forecasting the future burden of opioids for osteoarthritis.

Abstract:

OBJECTIVE:To quantify the current national burden of opioids for osteoarthritis (OA) pain in Australia in terms of number of dispensed opioid prescriptions and associated costs, and to forecast the likely burden to the year 2030/31. DESIGN:Epidemiological modelling. METHODS:Published data were obtained on rates of opioid prescribing for people with OA and national OA prevalence projections. Trends in opioid dispensing from 2006 to 2016, and average costs for common opioid subtypes were obtained from the Pharmaceutical Benefits Scheme and Medicare Australia Statistics. Using these inputs, a model was developed to estimate the likely number of dispensed opioid prescriptions and costs to the public healthcare system by 2030/31. RESULTS:In 2015/16, an estimated 1.1 million opioid prescriptions were dispensed in Australia for 403,954 people with OA (of a total 2.2 million Australians with OA). Based on recent dispensing trends and OA prevalence projections, the number of dispensed opioid prescriptions is expected to nearly triple to 3,032,332 by 2030/31, for an estimated 562,610 people with OA. The estimated cost to the Australian healthcare system was $AUD25.2 million in 2015/16, rising to $AUD72.4 million by 2030/31. CONCLUSION:OA-related opioid dispensing and associated costs are set to increase substantially in Australia from 2015/16 to 2030/31. Use of opioids for OA pain is concerning given joint disease chronicity and the risk of adverse events, particularly among older people. These projections represent a conservative estimate of the full financial burden given additional costs associated with opioid-related harms and out-of-pocket costs borne by patients.

authors

Ackerman IN,Zomer E,Gilmartin-Thomas JF,Liew D

doi

10.1016/j.joca.2017.11.001

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

350-355

issue

3

eissn

1063-4584

issn

1522-9653

pii

S1063-4584(17)31297-9

journal_volume

26

pub_type

杂志文章
  • Osteoarthritis biomarkers: year in review.

    abstract:OBJECTIVE:To summarise important findings from biomarker studies relevant to osteoarthritis (OA), published between April 2016 and March 2017; to consider these findings in the context of new discoveries and technologies, and clinical and scientific need in OA. DESIGN:Studies were selected by PubMed search, conducted ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2017.10.016

    authors: Watt FE

    更新日期:2018-03-01 00:00:00

  • Cell and matrix morphology in articular cartilage from adult human knee and ankle joints suggests depth-associated adaptations to biomechanical and anatomical roles.

    abstract:OBJECTIVE:Marked differences exist between human knee and ankle joints regarding risks and progression of osteoarthritis (OA). Pathomechanisms of degenerative joint disease may therefore differ in these joints, due to differences in tissue structure and function. Focusing on structural issues, which are design goals fo...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:

    authors: Quinn TM,Häuselmann HJ,Shintani N,Hunziker EB

    更新日期:2013-12-01 00:00:00

  • The effects of oral glucosamine on joint health: is a change in research approach needed?

    abstract:OBJECTIVE:Oral glucosamine (GlcN) has been widely studied for its potential therapeutic benefits in alleviating the pain and disability of osteoarthritis (OA). Its popularity has grown despite ongoing controversy regarding its effectiveness vs placebo in clinical trials, and lack of information regarding possible mecha...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2009.07.005

    authors: Block JA,Oegema TR,Sandy JD,Plaas A

    更新日期:2010-01-01 00:00:00

  • Risk factors for osteoarthritis: genetics.

    abstract::Although the multifactorial nature of osteoarthritis (OA) is well recognized, genetic factors have been found to be strong determinants of the disease. Evidence of a genetic influence of OA comes from a number of sources, including epidemiological studies of family history and family clustering, twin studies, and expl...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2003.09.005

    authors: Spector TD,MacGregor AJ

    更新日期:2004-01-01 00:00:00

  • Symptomatic efficacy of avocado-soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To evaluate the efficacy of preparations with avocado-soybean unsaponifiables (ASUs) in osteoarthritis (OA) patients using meta-analysis on randomized controlled trials (RCTs). METHOD:RCTs from systematic searches were included if they explicitly stated that hip and/or knee OA patients were randomized to eit...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.joca.2007.10.003

    authors: Christensen R,Bartels EM,Astrup A,Bliddal H

    更新日期:2008-04-01 00:00:00

  • C-reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study.

    abstract:OBJECTIVE:To explore the relationships between C-reactive protein (CRP), metabolic syndrome (MetS) and incidence of severe knee or hip osteoarthritis (OA) in a prospective study. METHODS:A population-based cohort (n=5171, mean age 57.5+/-5.9 years) was examined between 1991 and 1994. Data was collected on lifestyle ha...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2008.07.003

    authors: Engström G,Gerhardsson de Verdier M,Rollof J,Nilsson PM,Lohmander LS

    更新日期:2009-02-01 00:00:00

  • A quantitative metric for knee osteoarthritis: reference values of joint space loss.

    abstract:OBJECTIVES:Knee osteoarthritis (OA) onset and progression has been defined with transitions in Kellgren-Lawrence (KL) grade or Osteoarthritis Research Society International (OARSI) Joint Space Narrowing (JSN) grade. We quantitatively describe one-year transitions in KL grade and JSN, using fixed joint space width (fJSW...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2018.05.014

    authors: Ratzlaff C,Ashbeck EL,Guermazi A,Roemer FW,Duryea J,Kwoh CK

    更新日期:2018-09-01 00:00:00

  • Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.

    abstract:OBJECTIVE:The purpose of this study was to determine the effects of intra-articular injections of high molecular weight (2000 kDa) sodium hyaluronate (HA) on the progression of articular cartilage degeneration in a rabbit partial medial meniscectomy model of osteoarthritis. DESIGN:Six experimental groups included norm...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2003.11.007

    authors: Hulmes DJ,Marsden ME,Strachan RK,Harvey RE,McInnes N,Gardner DL

    更新日期:2004-03-01 00:00:00

  • Hypoxia, RONS and energy metabolism in articular cartilage.

    abstract:OBJECTIVE:Increased pro-inflammatory cytokines and reactive oxygen and nitrogen species (RONS) occur in osteoarthritis (OA). Oxygen tension can alter the levels of RONS induced by interleukin-1 (IL-1). RONS such as nitric oxide (NO) can alter energy metabolism. The aim of this study was to determine if oxygen tension a...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2010.06.004

    authors: Fermor B,Gurumurthy A,Diekman BO

    更新日期:2010-09-01 00:00:00

  • Joint distraction in treatment of osteoarthritis: a two-year follow-up of the ankle.

    abstract:OBJECTIVE:Osteoarthritis (OA) is a degenerative joint disease with an incidence exceeding 10% of the adult population. In end stages, OA can result in severe restriction of activity and consequent disability. For these severe cases of OA, no effective remedy is available yet. Joint distraction is a new experimental app...

    journal_title:Osteoarthritis and cartilage

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1053/joca.1998.0242

    authors: van Valburg AA,van Roermund PM,Marijnissen AC,van Melkebeek J,Lammens J,Verbout AJ,Lafeber FP,Bijlsma JW

    更新日期:1999-09-01 00:00:00

  • Radiographically normal knees with contralateral joint space narrowing display greater change in cartilage transverse relaxation time than those with normal contralateral knees: a model of early OA? - data from the Osteoarthritis Initiative (OAI).

    abstract:OBJECTIVE:To develop a model of early osteoarthritis, by examining whether radiographically normal knees with contralateral joint space narrowing (JSN), but without contralateral trauma history, display greater longitudinal cartilage composition change (transverse relaxation time; T2) than subjects with bilaterally nor...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2019.06.013

    authors: Wirth W,Maschek S,Roemer FW,Sharma L,Duda GN,Eckstein F

    更新日期:2019-11-01 00:00:00

  • Comparison of mouse and human ankles and establishment of mouse ankle osteoarthritis models by surgically-induced instability.

    abstract:OBJECTIVE:Prevalence of ankle osteoarthritis (OA) is lower than that of knee OA, however, the molecular mechanisms underlying the difference remain unrevealed. In the present study, we developed mouse ankle OA models for use as tools to investigate pathophysiology of ankle OA and molecular characteristics of ankle cart...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2015.11.008

    authors: Chang SH,Yasui T,Taketomi S,Matsumoto T,Kim-Kaneyama JR,Omiya T,Hosaka Y,Inui H,Omata Y,Yamagami R,Mori D,Yano F,Chung U,Tanaka S,Saito T

    更新日期:2016-04-01 00:00:00

  • Relationship between arthroscopic joint evaluation and the levels of Coll2-1, Coll2-1NO(2), and myeloperoxidase in the blood and synovial fluid of horses affected with osteochondrosis of the tarsocrural joint.

    abstract:OBJECTIVE:To evaluate the levels of plasmatic and synovial Coll2-1, Coll2-1NO(2) and myeloperoxidase (MPO) in horses with osteochondral lesions of the tarsocrural joint and to investigate how these levels relate to arthroscopic findings of inflammation and degeneration. MATERIALS AND METHODS:Venous blood and synovial ...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2011.08.002

    authors: Verwilghen DR,Enzerink E,Martens A,Franck T,Balligand M,Henrotin Y,Detilleux J,Serteyn D

    更新日期:2011-11-01 00:00:00

  • Elevated tibiofemoral articular contact stress predicts risk for bone marrow lesions and cartilage damage at 30 months.

    abstract:OBJECTIVE:As cartilage loss and bone marrow lesions (BMLs) are associated with knee joint pain and structural worsening, this study assessed whether non-invasive estimates of articular contact stress may longitudinally predict risk for worsening of knee cartilage morphology and BMLs. DESIGN:This was a longitudinal coh...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2012.05.013

    authors: Segal NA,Kern AM,Anderson DD,Niu J,Lynch J,Guermazi A,Torner JC,Brown TD,Nevitt M,Multicenter Osteoarthritis Study Group.

    更新日期:2012-10-01 00:00:00

  • OARSI recommendations for the management of hip and knee osteoarthritis: part III: Changes in evidence following systematic cumulative update of research published through January 2009.

    abstract:OBJECTIVE:To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31 January 2006 to 31 January 2009. METHODS:A systematic literature search was undertaken using MEDLINE, EMBASE, CINAHL, AMED, Science Citation Index and t...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.joca.2010.01.013

    authors: Zhang W,Nuki G,Moskowitz RW,Abramson S,Altman RD,Arden NK,Bierma-Zeinstra S,Brandt KD,Croft P,Doherty M,Dougados M,Hochberg M,Hunter DJ,Kwoh K,Lohmander LS,Tugwell P

    更新日期:2010-04-01 00:00:00

  • Degeneration alters the biomechanical properties and structural composition of lateral human menisci.

    abstract:OBJECTIVE:Because the literature relating to the influence of degeneration on the viscoelasticity and tissue composition of human lateral menisci remains contradictory or completely lacking, the aim of this study was to fill these gaps by comprehensively characterising the biomechanical properties of menisci with regar...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2020.07.004

    authors: Warnecke D,Balko J,Haas J,Bieger R,Leucht F,Wolf N,Schild NB,Stein SEC,Seitz AM,Ignatius A,Reichel H,Mizaikoff B,Dürselen L

    更新日期:2020-11-01 00:00:00

  • In vivo patellofemoral contact mechanics during active extension using a novel dynamic MRI-based methodology.

    abstract:OBJECTIVES:To establish an in vivo, normative patellofemoral (PF) cartilage contact mechanics database acquired during voluntary muscle control using a novel, dynamic, magnetic resonance (MR) imaging-based, computational methodology and validate the contact mechanics sensitivity to the known sub-millimeter methodologic...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2013.08.023

    authors: Borotikar BS,Sheehan FT

    更新日期:2013-12-01 00:00:00

  • Association between smoking and risk of knee osteoarthritis: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To investigate the association between smoking and the risk for knee osteoarthritis (OA). DESIGN:Cohort, case-control, and cross-sectional studies were obtained from the Medline, Embase, and Web of Science databases. Estimates were calculated using a random-effects model. Subgroup analyses and meta-regressio...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.joca.2016.12.020

    authors: Kong L,Wang L,Meng F,Cao J,Shen Y

    更新日期:2017-06-01 00:00:00

  • Lack of beneficial effects of low-dose radiation therapy on hand osteoarthritis symptoms and inflammation: a randomised, blinded, sham-controlled trial.

    abstract:OBJECTIVES:Low-dose radiation therapy (LDRT) is widely used as treatment for osteoarthritis (OA) in some countries, while relatively unknown in others. Systematic literature review displayed a lack of high-level evidence for beneficial effects in clinical practice. The aim was to assess the efficacy of LDRT on symptoms...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.joca.2018.06.010

    authors: Minten MJM,Leseman-Hoogenboom MM,Kloppenburg M,Kortekaas MC,Leer JW,Poortmans PMP,van den Hoogen FHJ,den Broeder AA,van den Ende CHM

    更新日期:2018-10-01 00:00:00

  • Inhibition of LRRK2 restores parkin-mediated mitophagy and attenuates intervertebral disc degeneration.

    abstract:OBJECTIVE:To elucidate the role of LRRK2 in intervertebral disc degeneration (IDD) as well as its mitophagy regulation mechanism. METHODS:The expression of LRRK2 in human degenerative nucleus pulposus tissues as well as in oxidative stress-induced rat nucleus pulposus cells (NPCs) was detected by western blot. LRRK2 w...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2021.01.002

    authors: Lin J,Zheng X,Zhang Z,Zhuge J,Shao Z,Huang C,Jin J,Chen X,Chen Y,Wu Y,Tian N,Sun L,Gao W,Zhou Y,Wang X,Zhang X

    更新日期:2021-01-09 00:00:00

  • Human genome-wide expression analysis reorients the study of inflammatory mediators and biomechanics in osteoarthritis.

    abstract::A major objective of this article is to examine the research implications of recently available genome-wide expression profiles of cartilage from human osteoarthritis (OA) joints. We propose that, when viewed in the light of extensive earlier work, this novel data provides a unique opportunity to reorient the design o...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,评审

    doi:10.1016/j.joca.2015.03.027

    authors: Sandy JD,Chan DD,Trevino RL,Wimmer MA,Plaas A

    更新日期:2015-11-01 00:00:00

  • Dimensionality and clinical importance of pain and disability in hand osteoarthritis: Development of the Australian/Canadian (AUSCAN) Osteoarthritis Hand Index.

    abstract:OBJECTIVE:To develop a reliable, valid, and responsive self-administered questionnaire to probe pain, stiffness and physical disability in patients with osteoarthritis (OA) of the hand. DESIGN:In order to assess the dimensionality of the symptomatology of hand OA, a self-administered questionnaire was developed to pro...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1053/joca.2002.0837

    authors: Bellamy N,Campbell J,Haraoui B,Buchbinder R,Hobby K,Roth JH,MacDermid JC

    更新日期:2002-11-01 00:00:00

  • Meniscal subluxation: association with osteoarthritis and joint space narrowing.

    abstract:OBJECTIVE:Since complete meniscectomy leads to knee OA, we investigated the potential links among meniscal subluxation, joint space narrowing and symptomatic OA. MATERIALS AND METHODS:233 cases with symptomatic knee OA and 58 asymptomatic controls underwent radiography and MR imaging of the knee. Joint space narrowing...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1053/joca.1999.0256

    authors: Gale DR,Chaisson CE,Totterman SM,Schwartz RK,Gale ME,Felson D

    更新日期:1999-11-01 00:00:00

  • A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia.

    abstract:OBJECTIVE:To describe the reproducibility and validity of six different measurement techniques for knee subchondral bone mineral density (sBMD). METHODS:A consecutive sample of 50 male and female participants from a population-based longitudinal study had sBMD assessed using dual energy X-ray absorptiometry scans. Ant...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2008.04.012

    authors: Dore D,Ding C,Jones G

    更新日期:2008-12-01 00:00:00

  • Falls risk is associated with pain and dysfunction but not radiographic osteoarthritis in older adults: Tasmanian Older Adult Cohort study.

    abstract:OBJECTIVE:To describe the association between knee and hip radiographic osteoarthritis (ROA), a measure of knee pain, stiffness and functional ability and objectively measured physiological falls risk predictors. METHODS:Cross-sectional, population-based study of 850 randomly selected men and women aged 50-80 years (m...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2005.12.007

    authors: Foley SJ,Lord SR,Srikanth V,Cooley H,Jones G

    更新日期:2006-06-01 00:00:00

  • The impact of early intra-articular administration of interleukin-1 receptor antagonist on lubricin metabolism and cartilage degeneration in an anterior cruciate ligament transection model.

    abstract:OBJECTIVE:Study the impact of intra-articular interleukin-1 receptor antagonist (IL-1 ra) treatment on lubricin biosynthesis following anterior cruciate ligament transection (ACLT) in the rat and evaluate the effect of combined IL-1 ra and recombinant human lubricin (rhPRG4) treatments on chondrocyte apoptosis. METHOD...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2014.09.006

    authors: Elsaid KA,Zhang L,Shaman Z,Patel C,Schmidt TA,Jay GD

    更新日期:2015-01-01 00:00:00

  • Magnetic resonance imaging characterization of osteochondral defect repair in a goat model at 8 T.

    abstract:OBJECTIVE:This study was performed to non-invasively visualize and characterize osteochondral (OC) repair in ex vivo goat stifles using an 8 T magnetic resonance imaging (MRI) scanner and to compare the MR morphology with images obtained from 1.5 T, gross morphology and histology. METHODS:Mature, neutered male goats w...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2005.08.006

    authors: Kangarlu A,Gahunia HK

    更新日期:2006-01-01 00:00:00

  • Effectiveness of thermal and athermal short-wave diathermy for the management of knee osteoarthritis: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To assess the effectiveness of short-wave diathermy (SWD) treatment in the management of knee osteoarthritis (KOA) and to assess whether the effects are related to the induction of a thermal effect. METHODS:A systematic literature search was conducted in PubMed, CINAHL, PEDro, EMBASE, SPORTdiscus and Scholar...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.joca.2012.05.005

    authors: Laufer Y,Dar G

    更新日期:2012-09-01 00:00:00

  • Measurement properties of the WOMAC LK 3.1 pain scale.

    abstract:OBJECTIVE:The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is applied extensively to patients with osteoarthritis of the hip or knee. Previous work has challenged the validity of its physical function scale however an extensive evaluation of its pain scale has not been reported. Our purpose wa...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2006.09.005

    authors: Stratford PW,Kennedy DM,Woodhouse LJ,Spadoni GF

    更新日期:2007-03-01 00:00:00

  • Comparative evaluation of three semi-quantitative radiographic grading techniques for hip osteoarthritis in terms of validity and reproducibility in 1404 radiographs: report of the OARSI-OMERACT Task Force.

    abstract:OBJECTIVE:The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods for hip osteoarthritis (OA). METHODS:In data obtained from trials and cohorts, radiographs were evaluated using the Kellgren and Lawrence (KL) grading system, the Osteoarthritis Research Society In...

    journal_title:Osteoarthritis and cartilage

    pub_type: 杂志文章

    doi:10.1016/j.joca.2008.06.009

    authors: Gossec L,Jordan JM,Lam MA,Fang F,Renner JB,Davis A,Hawker GA,Dougados M,Maillefert JF,OARSI-OMERACT task force \total articular replacement as outcome measure in OA\.

    更新日期:2009-02-01 00:00:00